Michael A. Pack, M.D.
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
GI Division, Department of Medicine
University of Pennsylvania
School of Medicine
Rm. 1212, BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
University of Pennsylvania
School of Medicine
Rm. 1212, BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215)573-4145
Email:
mpack@mail.med.upenn.edu
mpack@mail.med.upenn.edu
Publications
Education:
B.A.
State University of New York at Binghamton, 1980.
M.D.
Washington University, 1984.
Permanent linkB.A.
State University of New York at Binghamton, 1980.
M.D.
Washington University, 1984.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention
CVI Research Description:
We have two projects related to lipid absorption and or transport that fit with the ACS Prevention Program.
Selected Publications
Matthews RP, Lorent K, Mañoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M.: TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development 136(5): 865-75, 2009.Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC and Pack M.: Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress. PLoS Genetics 4(10), 2008.
Yee NS, Gong W, Huang Y, Lorent K, Dolan AC, Maraia RJ and Pack M: Mutation of RNA Polymerase III Subunit rpc2/polr3b Leads to Deficiency of the RNA Cleavage Subunit, Rpc11/Polr3k, and Disrupts Zebrafish Digestive System Development. PLOS Biology 5(11): e312, 2007.
Ho SY, Lorent K, Pack M* and Farber S. : Zebrafish fat-free, a gene required for intestinal lipid absorption, is essential for Golgi apparatus structure and vesicle recycling. Cell Metabolism 3(4): 289-300, 2006 Notes: * Co-Senior and co-communicating author.
Wallace KN, Dolan AC, Seiler C, Smith EM, Yusuff S, Chaille-Arnold L, Judson B, Sierk R, Yengo C, Sweeney HL and Pack M: Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Developmental Cell 8(5): 717-726, 2005.
Farber SA, Pack M*, Ho SY, Johnson SD, Wagner DS, Dosch R, Mullins MC, Hendrickson HS, Hendrickson EK and Halpern ME: Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters. Science 292: 1385-88, 2001 Notes: * Co-first and co-communicating author.
Matthews R, Lorent K and Pack M : The transcription factor onecut3 regulates intrahepatic biliary development in zebrafish. Developmental Dynamics 237(1): 124-31, 2008.
Wallace KN, Akhter S, Smith EN, Lorent K and Pack M. : Intestinal Growth and Differentiation in Zebrafish. Mechanisms of Development 122(2): 157-173, 2005.
Lorent K, Yeo SY, Oda T, Chandrasekharappa S, Chitnis A and Pack M. : Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development 131(22): 5753-66. 2004
Matthews R, Lorent K and Pack M. : Zebrafish vps33b, an ortholog of the gene responsible for human Arthrogryposis-Renal Dysfunction-Cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Development 132(23): 5295-5306, 2005.