Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Michael A. Pack, M.D.

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
GI Division, Department of Medicine
University of Pennsylvania
School of Medicine
Rm. 1212, BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215)573-4145
Education:
B.A.
State University of New York at Binghamton, 1980.
M.D.
Washington University, 1984.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We have two projects related to lipid absorption and or transport that fit with the ACS Prevention Program.

Selected Publications

Valvezan AJ, Huang J, Lengner CJ, Pack M, and Klein PS: Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease Models and Mechanisms 7(1): 63-71, 2014.

Wilkins BJ, Lorent K, Matthews RP, and Pack M: p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PLoS One 8(10): e77670, 2013.

Walters JA, Anderson JL, Bittman R, Pack M and Farber SA: Visualization of lipid metabolism in the larval zebrafish intestine reveals a relationship between NPC1L1 mediated cholesterol uptake and dietary fatty acids. Chemistry and Biology 19(7): 913-25, 2012.

Abrams J, Davuluri G, Seiler C, Pack M: Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Neurogastroenterology and Motililty 24(3): 288-99, 2012.

Seiler C, Davuluri G, Abrams J, Byfield FJ, Janye PA and Pack M: Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biology 10(9): e1001385, 2012.

Gao N, Davuluri G, Gong W, Seiler C, Furth EE, Kaestner K and Pack M : The Nuclear Pore Complex Proetin Elys is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells Gastroenterology 140(5): 1547-1555, 2011.

Matthews RP, Eua Claire SF, Mungier M, Lorent K, Cui Shuang, Zhang Z, Russo P and Pack M : DNA Hypomethylation Causes Bile Duct Injury in Zebrafish and Is a Distinguishing Feature of Infantile Biliary Atresia Hepatology 3(3): 905-14, 2011.

Davulri G, Seiler C, Abrams J, Soriano AJ and Pack M : Differential Effects of Thin and Thick Filament Disruption on Zebrafish Smooth Muscle Regulatory Proteins. Neurogastroenterology and Motility 22(10): 1100-e285, 2010.

Lorent K, Moore JC, Siekmann AF, Lawson N, Pack M. : Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Developmental Dynamics 239(3): 855-864, 2010.

Matthews RP, Lorent K, MaƱoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M.: TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development 136(5): 865-75, 2009.

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Last updated: 11/18/2014
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