Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Michael A. Pack, M.D.

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
GI Division, Department of Medicine
University of Pennsylvania
School of Medicine
Rm. 1212, BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215)573-4145
Education:
B.A.
State University of New York at Binghamton, 1980.
M.D.
Washington University, 1984.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We have two projects related to lipid absorption and or transport that fit with the ACS Prevention Program.

Selected Publications

Valvezan AJ, Huang J, Lengner CJ, Pack M, and Klein PS: Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease Models and Mechanisms 2013.

Wilkins BJ, Lorent K, Matthews RP, and Pack M: p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PLoS One 2013.

Walters JA, Anderson JL, Bittman R, Pack M and Farber SA: Visualization of lipid metabolism in the larval zebrafish intestine reveals a relationship between NPC1L1 mediated cholesterol uptake and dietary fatty acids. Chemistry and Biology 19(7)(913-25), June 2012.

Abrams J, Davuluri G, Seiler C, Pack M: Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Neurogastroenterology and Motililty 24(3): 288-99, 2012.

Seiler C, Davuluri G, Abrams J, Byfield FJ, Janye PA and Pack M: Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biology 10(9)(:e1001385), 2012.

Gao N, Davuluri G, Gong W, Seiler C, Furth EE, Kaestner K and Pack M : The Nuclear Pore Complex Proetin Elys is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells Gastroenterology 140(5): 1547-1555, 2011.

Matthews RP, Eua Claire SF, Mungier M, Lorent K, Cui Shuang, Zhang Z, Russo P and Pack M : DNA Hypomethylation Causes Bile Duct Injury in Zebrafish and Is a Distinguishing Feature of Infantile Biliary Atresia Hepatology 3(3): 905-14, 2011.

Davulri G, Seiler C, Abrams J, Soriano AJ and Pack M : Differential Effects of Thin and Thick Filament Disruption on Zebrafish Smooth Muscle Regulatory Proteins. Neurogastroenterology and Motility 22(10), 2010.

Lorent K, Moore JC, Siekmann AF, Lawson N, Pack M. : Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Developmental Dynamics 239(3): 855-864, 2010.

Matthews RP, Lorent K, MaƱoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M.: TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development 136(5): 865-75, 2009.

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Last updated: 04/24/2014
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