Thomas P. Cappola, MD, Sc.M
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
2 East Pereleman Center
3400 Civic Center Blvd.
Philadelphia, PA 19104
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-615-0805
Fax: 215-615-0828
Fax: 215-615-0828
Publications
Links
Search PubMed for articles
Penn CVI/IDOM Complex Genomics Initiative
Penn Health Profile
Cardiovascular Division Faculty
Search PubMed for articles
Penn CVI/IDOM Complex Genomics Initiative
Penn Health Profile
Cardiovascular Division Faculty
Education:
A.B. (Chemistry)
Princeton University, 1991.
MD ( Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2003.
Permanent linkA.B. (Chemistry)
Princeton University, 1991.
MD ( Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2003.
Description of CVI Expertise
CVI Program Unit(s):Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
CVI Research Description:
My group studies mechanisms of human cardiac remodeling using genomics, biomarkers, and proof-of-concept studies of novel therapeutics.
Current projects include:
1) Transcriptional Genomics of Human Heart Failure:
A novel approach that determines transcription factor activity in the failing human heart by integrating gene expression data, promoter sequence data, and transcription factor response element data. Results from these experiments have suggested a role for specific Forkhead (FOX) transcription factors in remodeling, which have become the major biologic focus of our research.
2) The Penn Heart Failure Study (PHFS):
A prospective observational cohort study of subjects with wide range of heart failure whose broad aim is to detect genomic and proteomic modifiers of heart failure progression. Biomarker and SNP/Haplotype association studies are currently underway in this cohort of ~800 subjects.
Selected Publications
Barouch LA, Cappola TP, Harrison RW, Crone JK, Burnett AL, Hare JM: Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol 35(6): 637-644, June 2003.Cappola TP, Cope L, Cernetich A, Barouch LA, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JGN, Hare JM: Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy. Physiological Genomics 14(1): 25-34, June 2003.
Horwitz PA, Epstein JA, Lepore JJ, Parmacek MS, Kao AC, Desai S, Goldberg LR, Jessup ML, Cappola, TP: Novel Predictors of Cardiac Allograft Rejection Determined by Peripheral Blood Gene Expression. American Heart Association Scientific Sessions 2003.
Barouch LA, Harrison RW, Skaf MM, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O’Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM: Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416(6878): 337-339, 2002.
Cappola TP, Felker GM, Kao WL, Hare JM, Baughman KL, Kasper EK: Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Circulation 105: 1663-1668, 2002.
Cappola TP, Rah B, Durrani S, Berkowitz DE, Hoffman E, Hare JM: NOS3 deficiency is associated with a shift toward pro-oxidant gene expression in murine myocardium. American College of Cardiology Scientific Sessions March 2002.
Durrani S, Cappola TP, Rah B, Berkowitz DE, Hoffman E, Hare JM: Assessment of the canine myocardial transcriptome in heart failure using redundant cross-species oligonucleotide arrays. American College of Cardiology Scientific Sessions March 2002.
Cappola TP, Cernetich A, Rah B, Durrani SA, Berkowitz DE, Hoffman EP, Hare JM: Nitric oxide deficiency modulates myocardial Gene transcription in a load-independent manner: implications for the pathogenesis of ventricular hypertrophy. Asia-Pacific Scientific Forum: The Genomic Revolution April 2002.
Cappola TP, Kass DA, Nelson GS, Berger RD, Rosas GO, Kobeissi ZA, Marbán E, Hare, JM: Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation 104(20): 2407-2411, 2001.
Cappola TP, Felker GM, Kao WL, Hare JM, Baughman KL, Kasper EK: Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Heart Failure Society of America Scientific Sessions September 2001.
| Protocol | Title | Status |
|---|---|---|
| 805585 | Warfarin versus Aspirin in Reduced Cardiac Ejection | Recruiting |
| 707391 | Penn Heart Failure Study (Zanthine Oxidase, Myocardial Genomics, and Heart Failure) | Recruiting |
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