Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Thomas P. Cappola, M.D., Sc.M.

Herbert C. Rorer Associate Professor in Medical Sciences
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Cardiovascular Medicine
9035 West Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
My group studies mechanisms of human heart failure using genomics, biomarkers, and proof-of-concept studies of novel therapeutics.

Current projects include:

1) The Penn Heart Failure Study (PHFS):
An NHLBI funded prospective observational cohort study of subjects with wide range of heart failure whose broad aim is to detect genomic and proteomic modifiers of heart failure progression. Recruitment (n = 2,300) is complete and a variety of analyses are underway.

2) Myocardial Applied Genomics Network (MAGNet)
This NHLBI funded program leverages the world's largest human myocardial biobank to for human myocardial eQTL mapping and systems genetics.

3) NHLBI Heart Failure Clinical Research Network
A phase two clinical trials network to test novel treatment strategies for advanced heart failure. We are currently leading a multi-center trial of liraglutide in patients with heart failrue and reduced ejection fraction.

Selected Publications

Liu Y, Morley M, Brandimarto J, Hannenhalli S, Hu Y, Ashley EA, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M; for the MAGNet consortium: RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics 105(2): 83-89, Feb 2015.

Tampakakis E, Leary PJ, Selby VN, De Marco T, Cappola TP, Felker GM, Russell SD, Kasper EK, Tedford RJ : The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease. JACC Heart Fail 3(1): 9-16, Jan 2015.

Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA : Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation 131(4): 371-80, Jan 2015.

Zhang R, Zhang Y, Zhang J, An T, Huang Y, Guo X, Januzzi JL, Cappola TP, Yin S, Wang Y, Zhou Q, Zou C, Ji S, Lv R : The prognostic value of plasma soluble ST2 in hospitalized Chinese patients with heart failure. PLoS One 9(10): e110976, Oct 2014.

Lu Y, Hannenhalli S, Cappola TP, Putt M: An evaluation of MC Logic and logicFS motivated by a study of the regulation of gene expression in heart failure. Journal of Applied Statistics 41(9): 1956-1975, Sep 2014.

Vorovich E, French B, Ky B, Goldberg L, Fang JC, Sweitzer NK, Cappola TP : Biomarker predictors of cardiac hospitalization in chronic heart failure: a recurrent event analysis. J Card Fail 20(8): 569-76, Aug 2014.

Margulies KB, Anstrom K, Hernandez AF, Redfield MM, Shah MR, Braunwald E, Cappola, TP: GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment (FIGHT) study Circ Heart Fail 7(4): 673-9, Jul 2014.

Basuray A, French B, Ky B, Sweitzer N, Vorovich E, Cappola TP, Fang JC: Heart failure with recovered ejection fraction: clinical description, biomarkers, and outcomes Circulation 129(23): 2380-7, Jun 2014.

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Elizabeth J., Rossin EJ, Morley M, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker P, Newton-Cheh C: Genetic association study of QT interval highlights calcium signaling pathways in myocardial repolarization. Nature Genetics 46(8): 826-36, Jun 2014.

Kapoor A, Sekar RB, Hansen NF, Fox-Talbot K, Morley M, Pihur V, Chatterjee S, Brandimarto J, Pfuefer A, Mullikin J, Ross M, Green E, Bentley D, Tomaselli GF, Cappola TP, Arking DE, Halushka MK, Chakravarti A: An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval Am J Hum Genet 94(6), May 2014.

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Last updated: 03/11/2015
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