Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Thomas P. Cappola, M.D., Sc.M.

Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Penn Cardiovascular Institute
11-102 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-0805
Fax: 215-746-7415
Lab: 215-573-4717
Education:
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
My group studies mechanisms of human heart failure using genomics, biomarkers, and proof-of-concept studies of novel therapeutics.

Current projects include:

1) The Penn Heart Failure Study (PHFS):
An NHLBI funded prospective observational cohort study of subjects with wide range of heart failure whose broad aim is to detect genomic and proteomic modifiers of heart failure progression. Recruitment (n = 2,300) is complete and a variety of analyses are underway.

2) Myocardial Applied Genomics Network (MAGNet)
This NHLBI funded program leverages the world's largest human myocardial biobank to for human myocardial eQTL mapping and systems genetics.

3) NHLBI Heart Failure Clinical Research Network
A phase two clinical trials network to test novel treatment strategies for advanced heart failure. We are currently leading a multi-center trial of liraglutide in patients with heart failrue and reduced ejection fraction.

Selected Publications

Zhang KW, French BC, Khan AM, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, St. John Sutton M, Cappola TP, Ky B: Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. J Am Heart Assoc 3(1), Jan 2014.

Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WHW, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Dávila-Román VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM: Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA 310(23): 2533-43, Dec 2013.

Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H, Del Monte F, Benjamin EJ, Cappola TP, Ellinor PT: Gene expression and genetic variation in human atria. Heart Rhythm Oct 2013.

Ky B, French B, Khan AM, Plappert T, Wang A, Chirinos JA, Fang JC, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP: Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. J Am Col Cardiol 62(13): 1165-72, Sep 2013.

Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM: BET bromodomains mediate transcriptional pause release in heart failure. Cell 154(3): 569-82, Aug 2013.

Fox ER, Musani SK, Barbalic M, Lin H, Yu B, Ogunyankin KO, Smith NL, Kutlar A, Glazer NL, Post WS, Paltoo DN, Dries DL, Farlow DN, Duarte ChW, Kardia SL, Meyers KJ, Sun YV, Arnett DK, Patki AA, Sha J, Cui X, Samdarshi TE, Penman AD, Bibbins-Domingo K, Buzkova P, Benjamin EJ, Bluemke DA, Morrison AC, Heiss G, Carr JJ, Tracy RP, Mosley TH, Taylor HA, Psaty BM, Heckbert SR, Cappola TP, Vasan RS: Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study. Circ Cardiovasc Genet 6(1): 37-46, Feb 2013.

Guo Y, Lanktree MB, Taylor KC, Fairfax BP, Elbers CC, Barnard J, Farrall M, Padmanabhan S, Baumert J, Castillo BA, Gaunt TR, Gong Y, Rajagopalan R, Romaine SP, Kumari M, Rafelt S, Smith EN, Li YR, Sivapalaratnam S, van Iperen EP, Speliotes EK, Toskala E, Zhang L, Ochs-Balcom HM, Bhangale TR, Chandrupatla HR, Drenos F, Gieger C, Gupta J, Johnson T, Kleber ME, Makino S, Mangino M, Meng Y, Nelson CP, Pankow JS, Pankratz N, Price TS, Shaffer J, Shen H, Tischfield S, Tomaszewski M, Atwood LD, Bailey KM, Balasubramanyam A, Baldwin CT, Basart H, Bauer F, Behr ER, Beitelshees AL, Berenson GS, Beresford SA, Bezzina CR, Bhatt DL, Boer JM, Braund PS, Burke GL, Burkley B, Carty C, Chen W, Clarke R, Cooper-DeHoff RM, Curtis SP, de Bakker PI, de Jong JS, Delles C, Dominiczak AF, Duggan D, Feldman HI, Furlong CE, Gorski MM, Gums JG, Hardwick R, Hastie C, Heid IM, Huang GH, Huggins GS, Humphries SE, Kirkland SA, Kivimaki M, Klein R, Klein BE, Knowler WC, Kottke-Marchant K, LaCroix AZ, Langaee TY, Li M, Lyon HN, Maiwald S, Marshall JK, Mehta A, Meijs MF, Melander O, Meyer N, Mitra N, Molony CM, Morrow DA, Murugesan G, Newhouse SJ, Nieto JF, Onland-Moret NC, Ouwehand WH, Palmen J, Pepine CJ, Ranchalis J, Rosas SE, Rosenthal EA, Scharnagl H, Schork NJ, Schreiner PJ, Shah T, Shashaty M, Shimbo D, Srinivasan SR, Thomas F, Tobin MD, Tsai MY, Verschuren WM, Wagenknecht LE, Winkelmann BR, Young T, Yusuf S, Zafarmand MH, Zmuda JM, Zwinderman AH, Anand SS, Balmforth AJ, Boehm BO, Boerwinkle E, Burton PR, Cappola TP, Casas JP, Caulfield MJ, Christiani DC, Christie J, Cruickshanks KJ, Davey-Smith G, Davidson KW, Day IN, Doevendans PA, Dorn GW 2nd, FitzGerald GA, Hall AS, Hingorani AD, Hirschhorn JN, Hofker MH, Hovingh KG, Illig T, Jamshidi Y, Jarvik GP, Johnson JA, Kanetsky PA, Kastelein JJ, Koenig W, Lawlor DA, März W, McCaffery J, Mega JL, Mitchell BD, Murray SS, O'Connell JR, Patel SR, Peters A, Pettinger M, Rader DJ, Redline S, Reilly MP, Sabatine MS, Schadt EE, Shuldiner AR, Silverstein RL, Spector TD, Taylor HA, Thorand B, Trip MD, Watkins H, Wichmann HE, Fox CS, Grant SF, Peter I, Talmud PJ, Munroe PB, Wilson JG, Knight JC, Samani NJ, Hegele RA, Asselbergs FW, Monda KL, van der Schouw YT, Demerath EW, Wijmenga C, Timpson NJ, Reiner AP, North KE, Papanicolaou GJ, Hakonarson H, Lange LA, Keating BJ: Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet 22(1): 184-201, Jan 2013.

Huang J, Elicker J, Bowens N, Liu X, Cheng L, Cappola TP, Zhu X, Parmacek MS: Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest 122(10): 3678-91, Oct 2012.

Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS: Myocardin-like protein 2 regulates TGF-beta signaling in embryonic stem cells and the developing vasculature. Development 139(19): 3531-42, Oct 2012.

French B, Saha-Chaudhuri P, Ky B, Cappola TP, Heagerty PJ: Development and evaluation of multi-marker risk scores for clinical prognosis. Stat Methods Med Res Jul 2012.

back to top
Last updated: 06/02/2014
The Trustees of the University of Pennsylvania