Sarah E. Millar, Ph.D.
Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations
Contact information
M8D Stellar-Chance Labs
422 Curie Blvd
Philadelphia, PA 19104
422 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-2633
Fax: (215) 573-9102
Fax: (215) 573-9102
Email:
millars@mail.med.upenn.edu
millars@mail.med.upenn.edu
Publications
Education:
B.A. (Biochemistry)
Cambridge University, U.K., 1982.
Ph.D. (Molecular Biology)
University of London, U.K., 1987.
Permanent linkB.A. (Biochemistry)
Cambridge University, U.K., 1982.
Ph.D. (Molecular Biology)
University of London, U.K., 1987.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
CVI Research Description:
We are interested in the functions of Wnt signaling, miRNAs and histone deacetylase enzymes in mammalian development, postnatal homeostasis, regeneration and disease. Our primary focus is the development and renewal of skin, hair follicles, teeth and mammary glands. We have collaborative interests in the areas of lung and heart development.
Selected Publications
Andl, T., Reddy S. T., Gaddapara, T. & Millar, S. E. : WNT signals are required for the initiation of hair follicle development. Developmental Cell 2: 643-653, 2002.Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. : Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131: 4819-4829, 2004.
Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C, D., Seykora, J. T., Hannon, G. J., Millar, S. E.: The miRNA processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology 6: 1041-9, 2006.
Liu, F., Thirumangalathu, S., Gallant, N. M., Yang, S. H., Stoick-Cooper, C. L., Reddy, S. T., Andl, T., Taketo, M. M., Dlugosz, A. A., Moon, R. T., Barlow, L. A., Millar, S. E.: Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 39: 106-12, 2007.
Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S., Lu, M-M., Piccolo, S., Schmidt-Ullrich, R., Taketo M. M., Morrisey, E. E., Atit, R., Dlugosz, A. A., Millar, S. E.: Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev. Biol. 313: 210-24, 2008.
Zhang, Y., Andl, T., Yang, S.H., Teta, M., Liu, F., Seykora, J.T., Tobias, J.W., Piccolo, S., Schmidt-Ullrich, R., Nagy, A., Taketo, M.M., Dlugosz, A.A., Millar, S.E.: Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135: 2161-72, June 2008 Notes: Highlighted paper. Epub 2008 May 14.
Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek P, Scheidereit C, Millar SE*, Schmidt-Ullrich R*. [*Joint last and corresponding authors.]: Reciprocal requirements for Eda/Edar/NF-kappa B and Wnt/b-catenin signaling pathways in hair follicle induction. Developmental Cell 17, 49-61 2009.
Liu F, Dangaria S, Andl T, Zhang Y, Wright A C, Damek-Poprawa M, Piccolo S, Nagy A, Taketo M M, Diekwisch T G H, Akintoye S O, Millar S E: beta-Catenin initiates tooth neogenesis in adult rodent incisors. Journal of Dental Research 89(9): 909-14, Sep 2010.
LeBoeuf Matthew, Terrell Anne, Trivedi Sohum, Sinha Satrajit, Epstein Jonathan A, Olson Eric N, Morrisey Edward E, Millar Sarah E: Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Developmental Cell 19(6): 807-18, Dec 2010.
Teta Monica, Choi Yeon Sook, Okegbe Tishina, Wong Gabrielle, Tam Oliver H, Chong Mark M W, Seykora John T, Nagy Andras, Littman Dan R, Andl Thomas, Millar Sarah E: Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (Cambridge, England) 139(8): 1405-16, Apr 2012.