Sarah E. Millar, Ph.D.
Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations
Contact information
M8D Stellar-Chance Labs
422 Curie Blvd
Philadelphia, PA 19104
422 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-2633
Fax: (215) 573-9102
Fax: (215) 573-9102
Email:
millars@mail.med.upenn.edu
millars@mail.med.upenn.edu
Publications
Education:
B.A. (Biochemistry)
Cambridge University, U.K., 1982.
Ph.D. (Molecular Biology)
University of London, U.K., 1987.
Permanent linkB.A. (Biochemistry)
Cambridge University, U.K., 1982.
Ph.D. (Molecular Biology)
University of London, U.K., 1987.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
CVI Research Description:
We are interested in WNT signaling, BMP signaling and miRNA function in mammalian development and postnatal life. Our primary focus is the development of skin, hair follicles, teeth and mammary glands. We have collaborative interests in the areas of lung and heart development.
Selected Publications
Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek P, Scheidereit C, Millar SE*, Schmidt-Ullrich R*. [*Joint last and corresponding authors.]: Reciprocal requirements for Eda/Edar/NF-kappa B and Wnt/b-catenin signaling pathways in hair follicle induction. Developmental Cell 17, 49-61 2009.Yang, S. H., Andl, T., Gratchchouk, V., Wang, A., Liu, J., Syu, L.-J., Ferris, J, Glick, A. B., Millar, S. E., Dlogosz, A. A.: Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling. Nat Genetics 40: 1130-1135, August 2008 Notes: Subject of a News and Views article: Nature Genetics 40, 1040-1041 (2008).
Zhang, Y., Andl, T., Yang, S.H., Teta, M., Liu, F., Seykora, J.T., Tobias, J.W., Piccolo, S., Schmidt-Ullrich, R., Nagy, A., Taketo, M.M., Dlugosz, A.A., Millar, S.E.: Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135: 2161-72, June 2008 Notes: Highlighted paper. Epub 2008 May 14.
Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S., Lu, M-M., Piccolo, S., Schmidt-Ullrich, R., Taketo M. M., Morrisey, E. E., Atit, R., Dlugosz, A. A., Millar, S. E.: Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev. Biol. 313: 210-24, 2008.
Liu, F., Thirumangalathu, S., Gallant, N. M., Yang, S. H., Stoick-Cooper, C. L., Reddy, S. T., Andl, T., Taketo, M. M., Dlugosz, A. A., Moon, R. T., Barlow, L. A., Millar, S. E.: Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 39: 106-12, 2007.
Stark, J., Andl, T. Millar, S. E. : Hairy Math: Insights into hair-follicle spacing and orientation. Cell 128: 17-20, 2007.
Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C, D., Seykora, J. T., Hannon, G. J., Millar, S. E.: The miRNA processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology 6: 1041-9, 2006.
Andl, T., Ahn, K., Kairo, A., Chu, E. Y., Wine-Lee, L., Reddy, S. T., Croft, N. C., Cebra-Thomas, J. A., Metzger, D., Chambon, P., Lyons, K. M., Mishina, Y., Seykora, J. T., Crenshaw, E. B., & Millar, S. E. : Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 131: 2257-2268, 2004.
Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. : Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131: 4819-4829, 2004.
Andl, T., Reddy S. T., Gaddapara, T. & Millar, S. E. : WNT signals are required for the initiation of hair follicle development. Developmental Cell 2: 643-653, 2002.