Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

Sarah E. Millar, Ph.D.

Albert M. Kligman Professor in Dermatology II
Department: Dermatology
Graduate Group Affiliations

Contact information
1005 BRB II/III
421 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-2633
Fax: (215) 573-9102
Education:
B.A. (Biochemistry)
Cambridge University, U.K., 1982.
Ph.D. (Molecular Biology)
University of London, U.K., 1987.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease

CVI Research Description:
We are interested in the functions of Wnt signaling, miRNAs and histone deacetylase enzymes in mammalian development, postnatal homeostasis, regeneration and disease. Our primary focus is the development and renewal of skin, hair follicles, teeth and mammary glands. We have collaborative interests in the areas of lung and heart development.

Selected Publications

Xu Mingang, Horrell Jeremy, Snitow Melinda, Cui Jiawei, Gochnauer Heather, Syrett Camille M, Kallish Staci, Seykora John T, Liu Fei, Gaillard Dany, Katz Jonathan P, Kaestner Klaus H, Levin Brooke, Mansfield Corinne, Douglas Jennifer E, Cowart Beverly J, Tordoff Michael, Liu Fang, Zhu Xuming, Barlow Linda A, Rubin Adam I, McGrath John A, Morrisey Edward E, Chu Emily Y, Millar Sarah E: WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature communications 8: 15397, Jun 2017.

Choi Yeon Sook, Zhang Yuhang, Xu Mingang, Yang Yongguang, Ito Mayumi, Peng Tien, Cui Zheng, Nagy Andras, Hadjantonakis Anna-Katerina, Lang Richard A, Cotsarelis George, Andl Thomas, Morrisey Edward E, Millar Sarah E: Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell stem cell 13(6): 720-33, Dec 2013 Notes: Subject of a Preview Article in Cell Stem Cell: Morgan BA. (2013). The "skinny" on Wnt signaling in stem cells. Cell Stem Cell 13, 638-40. -Subject of a Preview Article in Science: Frede J, Jones PH. (2013). Development. Permission to proliferate. Science 342, 1183-4.

Teta Monica, Choi Yeon Sook, Okegbe Tishina, Wong Gabrielle, Tam Oliver H, Chong Mark M W, Seykora John T, Nagy Andras, Littman Dan R, Andl Thomas, Millar Sarah E: Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (Cambridge, England) 139(8): 1405-16, Apr 2012.

LeBoeuf Matthew, Terrell Anne, Trivedi Sohum, Sinha Satrajit, Epstein Jonathan A, Olson Eric N, Morrisey Edward E, Millar Sarah E: Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Developmental Cell 19(6): 807-18, Dec 2010.

Liu F, Dangaria S, Andl T, Zhang Y, Wright A C, Damek-Poprawa M, Piccolo S, Nagy A, Taketo M M, Diekwisch T G H, Akintoye S O, Millar S E: beta-Catenin initiates tooth neogenesis in adult rodent incisors. Journal of Dental Research 89(9): 909-14, Sep 2010.

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek P, Scheidereit C, Millar SE*, Schmidt-Ullrich R*. [*Joint last and corresponding authors.]: Reciprocal requirements for Eda/Edar/NF-kappa B and Wnt/b-catenin signaling pathways in hair follicle induction. Developmental Cell 17, 49-61 2009.

Zhang, Y., Andl, T., Yang, S.H., Teta, M., Liu, F., Seykora, J.T., Tobias, J.W., Piccolo, S., Schmidt-Ullrich, R., Nagy, A., Taketo, M.M., Dlugosz, A.A., Millar, S.E.: Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135: 2161-72, June 2008 Notes: Highlighted paper. Epub 2008 May 14.

Liu, F., Thirumangalathu, S., Gallant, N. M., Yang, S. H., Stoick-Cooper, C. L., Reddy, S. T., Andl, T., Taketo, M. M., Dlugosz, A. A., Moon, R. T., Barlow, L. A., Millar, S. E.: Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 39: 106-12, 2007.

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C, D., Seykora, J. T., Hannon, G. J., Millar, S. E.: The miRNA processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology 6: 1041-9, 2006.

Andl, T., Reddy S. T., Gaddapara, T. & Millar, S. E. : WNT signals are required for the initiation of hair follicle development. Developmental Cell 2: 643-653, 2002.

back to top
Last updated: 10/27/2017
The Trustees of the University of Pennsylvania
 
© The Trustees of the University of Pennsylvania. Site best viewed with Mozilla, NN, IE, or Safari.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration