Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Bonnie Ky, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-573-6606
Fax: 215-746-7415
BS (Chemical Engineering )
Massachusetts Institute of Technology, 1995.
MD (Medicine)
University of Pennsylvania, 2001.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2009.
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Description of CVI Expertise

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and chemotherapy cardiotoxicity. Current projects include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.

We are also engaged in a study of genetic variations in the neuregulin/ErbB signaling pathway and how they relate to circulating levels, cardiac remodeling, and clinical outcomes in these and other community-based cohorts. We are actively collaborating on a therapeutics trial of neuregulin in systolic heart failure.

2) Chemotherapy Cardiotoxicity:
We are interested in defining novel circulating biomarker, genetic variations, and sensitive echocardiographic indices predictive of chemotherapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the potential dsyregulation of various pathway-based markers in the pathophysiology of this disease.

Selected Publications

Ky B, Putt ME, Sawaya H, French B, Sebag I, Plana JC, Januzzi JL, Tan TC, Cohen V, Banchs J, Carver J, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M: Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab. Journal of the American College of Cardiology 63(8): 809-16, March 2014.

Zhang KW, French B, Khan AM, Plappert T, Fang JC, Sweitzer NK, St John Sutton M, Cappola TP, Ky B: Strain Improves Risk Prediction Beyond Ejection Fraction in Chronic Systolic Heart Failure. Journal of the American Heart Association 3(1), January 2014.

Basuray A, French B, Ky B, Sweitzer NK, Vorovich E, Cappola TP, Fang JC: Heart Failure with Recovered Ejection Fraction: Clinical Description, Biomarkers, and Outcomes. . Under Review 2014.

Vorovich E, French B, Ky B, Fang JC, Sweitzer NK, Cappola TP: Biomarker Predictors of Recurrent Cardiac Hospitalization in Chronic Heart Failure. . Under review 2014.

Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Dávila-Román VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM; NHLBI Heart Failure Clinical Research Network: Low-dose Dopamine or Low-dose Nesiritide in Acute Heart Failure with Renal Dysfunction: the ROSE Acute Heart Failure Randomized Trial. Journal of the American Medical Association 310(23): 2533-43, December 2013.

Ky B, French B, Khan AM, Plappert T, Wang A, Chirinos JA, Fang JA, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP: Ventricular-Arterial Coupling, Remodeling, and Prognosis in Chronic Heart Failure. Journal of the American College of Cardiology 62(13): 1165-72, September 2013 Notes: Epub June 2013.

Ky B, Shults J, Keane MG, St John Sutton M, Wolf M, Feldman HI, Reese P, Anderson C, Townsend R, Lo J, Gadegeku C, Carlow D, Sulik M, Leonard MB: FGF23 Modifies the Relationship Between Vitamin D and Cardiac Remodeling. Circulation Heart Failure 6(4): 817-24, July 2013.

Reese PP, Cappola AR, Shults J, Townsend R, Gadegeku C, Anderson C, Baker J Carlow D, Sulik M, Lo J, Go A, Ky B, Mariani L, Feldman HI, Leonard MB: Physical Performance and Frailty in Chronic Kidney Disease. American Journal of Nephrology 38(4): 307-15, 2013 Notes: Epub October.

Christian JB, Finkle JK, Ky B, Douglas PS, Gutstein DE, Hockings PD, Lainee P, Lenihan DJ, Mason JW, Sager PT, Todaro TG, Hicks KA, Ko H, Lindenfeld J, Michelson EL, Milligan J, Munley JY, Taichlen JS, Shahlaee A, Strnadova C, Ye B, Turner JR: Cardiac Imaging Approaches to Evaluate Drug-Induced Myocardial Dysfunction. American Heart Journal 164(6): 846-55, December 2012.

Sawaya H, Sebag I, Plana JC, Januzzi JL, Ky B, Tan TC, Cohen V, Banchs J, Carver J, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M: Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated with Anthracyclines, Taxanes, and Trastuzumab. Circulation Cardiovascular Imaging 5(5): 596-603, September 2012.

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Last updated: 03/07/2014
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