CVI Program Unit(s):
Myocyte Biology / Heart Failure
CVI Research Description:
The Gorman Cardiovascular Research Group
is funded by several NIH grants, philanthropic grants and industrial contracts. This spring the group will be moving to a new facility in Glenolden Pennsylvania.
That facility will include:
Three large animal operating rooms, a cath lab, MRI, 3D echocardiography
capabilities as well as vastly expanded wet lab and office space.
The Group's Research interests include:
1) Pathophysiology of heart failure (HF)
2) Novel pharmacologic therapy for treating HF
3) Effect of left ventricular assist devices on ventricular remodeling and HF
4) Scientific evaluation of surgical procedures/devices in the treatment of HF
5) Cardiac Imaging: MRI & real time 3D echocardiography
6) Mitral valve physiology
7) Design of novel annuloplasty rings
8) Percutaneous valve repair/replacement
9) Anorexigen induced valve disease
10) Effect of selective ventricular pacing on HF
11) Development of material/processes to limit prosthetic valve calcification.
The Group collaborates with clinicians, cardiovascular scientists and engineers in both academia and industry to discover novel solutions to important cardiovascular disease.
Contijoch F, Witschey WRT, Rogers K, Gorman III JH, Gorman RC, Ferrari VA, Han Y: The Impact of End-Diastolic and End-Systolic Phase Selection in the Volumetric Evaluation of Cardiac MRI. Journal of Magnetic Resonance Imaging 43: 585–593, 2016.
Aggarwal A, Pouch AM, Lai E, Lesicko J, Yushkevich PA, Gorman III JH, Gorman RC, Sacks MS: In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. Journal of Biomechanics 2016 Notes: In Press.
Pierce EL, Gentile J, Siefert AW, Gorman RC, Gorman III JH, Yoganathan AP: Real-Time Recording of Annuloplasty Suture Dehiscence Reveals Potential Mechanism for Dehiscence Cascade. Journal of Thoracic and Cardiovascular Surgery 2016 Notes: In Press.
Pierce EL, Siefert AW, Paul DM, Wells SK, Bloodworth IVCH, Takebayashi S, Aoki C, Jensen MO, Gillespie MJ, Gorman RC, Gorman III JH, Yoganathan AP: How Local Annular Force and Collagen Density Govern Mitral Annuloplasty Ring Dehiscence Risk. Annals of Thoracic Surgery 2016 Notes: In Press.
Pouch AM, Jackson BM, Lai E, Takabe M, Tian S, Cheung AT, Woo YJ, Patel P, Wang H, Yushkevich PA, Gorman RC, Gorman III JH: Automated 3D Echocardiographic Reconstruction of the Myxomatous Mitral Valve. Annals of Thoracic Surgery 2016 Notes: In Press.
Bouma W, Lai EK, Levack MM, Shang EK, Pouch AM, Eperjesi TJ, Yushkevich PA, Mariani MA, Khabbaz KR, Gleason TG, Mahmood F, Acker MA, Woo YJ, Cheung AT, Jackson BM, Gorman III JH, Gorman RC: Preoperative Three-Dimensional Valve Analysis Predicts Recurrent Ischemic Mitral Regurgitation after Mitral Annuloplasty. Annals of Thoracic Surgery 101: 567–75, 2016.
Nikou A, Dorsey SM, McGarvey JM, Gorman III JH, Burdick JA, Pilla JJ, Gorman RC, Wenk JF: Computational Modeling of Healthy Myocardium in Diastole. Annals of Biomedical Engineering 2016 Notes: In Press.
Contijoch F, Witschey WRT, McGarvey J, Lee MA, Gorman JH III, Gorman RC, Pilla JJ: Slice-by-slice PV loop analysis demonstrates regional differences in cardiac contractility and regional dependence on inotropic agents. Annals of Thoracic Surgery 2016 Notes: In Press.
Sacks MS, Yoganathan, AP Gorman RC, Gorman III JH: Heart Valve Functional Physiology. Annual Review of Biomedical Engineering 17: 1, 2015.
Mojsejenko D, McGarvey JR, Dorsey SM, Gorman III JH, Burdick JA, Pilla JJ, Gorman RC, Wenk JF: Estimating Passive Mechanical Properties in a Myocardial Infarction using MRI and Finite Element Simulations. Biomechanics and Modeling in Mechanobiology 14: 633-647, 2015.
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Last updated: 06/10/2016
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