CVI Program Unit(s):
Myocyte Biology / Heart Failure
CVI Research Description:
The Gorman Cardiovascular Research Group
is funded by several NIH grants, philanthropic grants and industrial contracts. This spring the group will be moving to a new facility in Glenolden Pennsylvania.
That facility will include:
Three large animal operating rooms, a cath lab, MRI, 3D echocardiography
capabilities as well as vastly expanded wet lab and office space.
The Group's Research interests include:
1) Pathophysiology of heart failure (HF)
2) Novel pharmacologic therapy for treating HF
3) Effect of left ventricular assist devices on ventricular remodeling and HF
4) Scientific evaluation of surgical procedures/devices in the treatment of HF
5) Cardiac Imaging: MRI & real time 3D echocardiography
6) Mitral valve physiology
7) Design of novel annuloplasty rings
8) Percutaneous valve repair/replacement
9) Anorexigen induced valve disease
10) Effect of selective ventricular pacing on HF
11) Development of material/processes to limit prosthetic valve calcification.
The Group collaborates with clinicians, cardiovascular scientists and engineers in both academia and industry to discover novel solutions to important cardiovascular disease.
Branchetti E, Sainger R, Poggio P, Grau JB, Jeffery PF, Bavaria JB, Horny C, Lai E, Gorman III JH, Gorman RC, Levy RJ, Ferrari G.: Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: e66-e74, 2013.
Shang EK, Nathan DP, Sprinkle SR, Vigmostad SC, Fairman RM, Bavaria JE, Gorman RC, Gorman III JH, Chandran KB, Jackson BM.: Peak Wall Stress Predicts Expansion Rate in Descending Thoracic Aortic Aneurysms. Annals of Thoracic Surgery 95: 593-598, 2013.
Aggarwal A, Aguilar VS, Lee CH, Ferrari G, Gorman III JH, Amini R, Sacks MS.: Patient-Specific Modeling of Heart Valves: From Image to Simulation. Lecture Notes in Computer Science 7945: 141-149, 2013.
Siefert AW, Rabbah JP, Koomalsingh KJ, Touchton Jr. SA, Neelakantan S, McGarvey JR, Gorman RC, Gorman III JH, Yoganathan AP.: In-Vitro Mitral Valve Simulator Mimics Systolic Valvular Function of Chronic Ischemic Mitral Regurgitation Ovine Model. Annals of Thoracic Surgery 95: 825-830, 2013.
Burdick JA, Mauck RL, Gorman III JH, Gorman RC.: Acellular Biomaterials to Induce Endogenous Tissue Repair. Science Translational Medicine 5: 176ps4, 2013.
Mahmood F, Kim H, Chaudary B, Bergman R, Matyal R, Gerstle J, Gorman III JH, Gorman RC, Khabbaz KR. : Tricuspid Annular Geometry: A Three-Dimensional Transesophageal Echocardiographic Study. Journal of Cardiothoracic and Vascular Anesthesia 27: 639-646, 2013.
Goldstone AB, Atluri P, Szeto WY, Trubelja A, Howard JL, MacArthur JW, Newcomb C, Donnelly JP, Kobrin DM, Sheridan MA, Powers C, Gorman RC, Gorman III JH, Pochettino A, Bavaria JB, Acker MA, Hargrove III WC, Woo YJ.: Minimally Invasive Approach Provides at Least Equivalent Results for Surgical Correction of Mitral Regurgitation: A Propensity Matched Comparison. Journals of Thoracic and Cardiovascular Surgery 145: 748-756, 2013.
Vergnat M, Levack MM, Jackson BM, Bavaria JE, Hermann HC, Cheung AT, Weiss SJ, Gorman III JH, Gorman RC.: The Effect of Surgical and Transcatheter Aortic Valve Replacement on Mitral Annular Anatomy. Annals of Thoracic Surgery 95: 614-620, 2013.
Siefert AW, Jimenez JH, Koomalsingh KJ, Aguel F, Shuto T, Snow TK, Gorman RC, Gorman III JH, Yoganathan AJ.: Contractile Mitral Annular Forces Are Reduced with Ischemic Mitral Regurgitation. Journal of Thoracic Surgery 146: 422-428, 2013.
Sainger R, Grau JB, Branchetii E, Poggio P, Lai E, Koka E, Vernick WJ, Gorman III JH, Gorman RC, Bavaria JB, Ferrari G.: Comparison of Transesophageal Echocardiographic Analysis and Circulating Biomarker Expression Profile in Calcific Aortic Valve Disease. Journal of Heart Valve Disease 22: 156-165, 2013.
back to top
Last updated: 05/25/2016
The Trustees of the University of Pennsylvania