Joseph H. Gorman, III
Associate Professor of Surgery
Department: Surgery
Contact information
Division of Cardiothoracic Surgery
University of Pennsylvania School of Medicine
313 Stemmler Hall,
3450 Hamilton Walk
Philadelphia, PA 19104-4283
University of Pennsylvania School of Medicine
313 Stemmler Hall,
3450 Hamilton Walk
Philadelphia, PA 19104-4283
Office: (215) 615-0977
Fax: (215) 349-5798
Fax: (215) 349-5798
Email:
gormanj@uphs.upenn.edu
gormanj@uphs.upenn.edu
Publications
Education
B.S.Ch.E.
New Jersey Institute of Technology/Newark College of Engineering, Department of Chemical Engineering and Chemistry, Newark, NJ , 1984.
M.D.
University of Medicine and Dentistry of New Jersey/ Robert Wood Johnson Medical School, New Brunswick, NJ , 1991.
Permanent linkB.S.Ch.E.
New Jersey Institute of Technology/Newark College of Engineering, Department of Chemical Engineering and Chemistry, Newark, NJ , 1984.
M.D.
University of Medicine and Dentistry of New Jersey/ Robert Wood Johnson Medical School, New Brunswick, NJ , 1991.
Description of CVI Expertise
CVI Program Unit(s):Myocyte Biology / Heart Failure
CVI Research Description:
The Gorman Cardiovascular Research Group is funded by several NIH grants, philanthropic grants and industrial contracts. This spring the group will be moving to a new facility in Glenolden Pennsylvania.
That facility will include:
Three large animal operating rooms, a cath lab, MRI, 3D echocardiography
capabilities as well as vastly expanded wet lab and office space.
The Group's Research interests include:
1) Pathophysiology of heart failure (HF)
2) Novel pharmacologic therapy for treating HF
3) Effect of left ventricular assist devices on ventricular remodeling and HF
4) Scientific evaluation of surgical procedures/devices in the treatment of HF
5) Cardiac Imaging: MRI & real time 3D echocardiography
6) Mitral valve physiology
7) Design of novel annuloplasty rings
8) Percutaneous valve repair/replacement
9) Anorexigen induced valve disease
10) Effect of selective ventricular pacing on HF
11) Development of material/processes to limit prosthetic valve calcification.
The Group collaborates with clinicians, cardiovascular scientists and engineers in both academia and industry to discover novel solutions to important cardiovascular disease.
Selected Publications
Naimark WA, Lepore JJ, Klugherz BD, Wang Z, Guy TS, Osman H, Moainie SL, Gorman RC, Reed G, Gorman JH 3rd, Palasis M, Parmacek MS, Wilensky RL: Adenovirus-catheter compatibility increases gene expression after delivery to porcine myocardium. Human Gene Therapy 14(2): 161-166, January 2003.Jackson BM, Gorman JH 3rd, Salgo IS, Moainie SL, Plappert T, St John-Sutton M, Edmunds LH Jr, Gorman RC: Border zone geometry increases wall stress after myocardial infarction: Contrast echocardiographic assessment. American Journal of Physiology - Heart & Circulatory Physiology. 284(2): H475-479, February 2003.
Wilson EM, Moainie SL, Baskin JM, Lowry AS, Deschamps AM, Mukherjee R, Guy TS, St John-Sutton MG, Gorman JH 3rd, Edmunds LH Jr, Gorman RC, Spinale FG: Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation 107(22): 2857-63, June 2003.
Gorman RC, Gorman JH III: Potential role of ventricular compressive therapy: Surgical options in heart failure. Surgical Clinics of North America (in press) 2003.
Gorman III JH, Gorman RC, Jackson BM, Enomoto Y, St. John-Sutton MG, Edmunds Jr LH. : Annuloplasty ring selection for chronic ischemic mitral regurgitation: Lessons from the ovine model. Annals of Thoracic Surgery (in press) 2003.
Gorman III JH, Jackson BM, Enomoto Y, Gorman RC: The effect of regional ischemia on mitral valve annular saddle shape and function. Annals of Thoracic Surgery (in press) 2003.
Gorman III JH, Jackson BM, Moainie SL, Enomoto Y, Gorman RC: The influence of inotropy and chronotropy on the mitral valve sphincter mechanism. Annals of Thoracic Surgery (in press) 2003.
Nasuti J, Zhang PJ, Feldman MD, Pasha T, Khurana JS, Gorman III JH, Gorman RC, Narula J MD, Narula N: Fibrillin and other matrix proteins in mitral valve prolapse syndrome. Annals of Thoracic Surgery (in press) 2003.
Guy IV TS, Moainie SL, Gorman III JH, Jackson BM, Plappert T, Enomoto Y, St. John Sutton MG, Edmunds Jr LH, Gorman RC: Prevention of ischemic mitral regurgitation does not influence the outcome of remodeling after posterolateral myocardial infarction. Journal of the American College of Cardiology (in press) 2003.
Jackson BM, Gorman III JH, Gorman RC: Increased borderzone stress in bulging ventricular aneurysm. Annals of Thoracic Surgery (in press) 2003.
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