faculty photo

Robert J. Levy, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
Heart valve disease, gene delivery stents, biomaterials, nanotechnology

Selected Publications

Cohen-Sacks H, Elazar V, Gao J, Golomb A, Adwan H, Korchov N, Levy RJ, Berger MR, Golomb G: Delivery and expression of pDNA embedded in collagen matrices. Journal of Control Release 95: 309-320, 2004.

Jian B, Narula N, Li Q, Mohler ER, Levy RJ: Progression of aortic valve stenosis: TGF-b1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Annals of Thoracic Surgery 75: 457-465, 2003.

Levy, RJ, Vyavahare N, Ogle M, Ashworth P, Bianco R, Schoen FJ: Inhibition of cusp and aortic wall calcification in ethanol and aluminum pretreated bioprosthetic heart valves in sheep: Background, mechanisms, and synergism. Journal of Heart Valve Disease 12: 209-216, 2003.

Ogle, M.F., Kelly, S.J., Bianco, R.W., Levy, R.J.: Calcification resistance with aluminum- ethanol treated porcine aortic valve bioprostheses in juvenile sheep. Annals of Thoracic Surgery 75: 1267-1273, 2003.

Burton DY, Song C, Fishbein I, Hazelwood S, Li Q, DeFelice S, Connolly JM, Perlstein I, Coulter DA, Levy RJ: The incorporation of an ion channel gene mutation associated with the Long QT syndrome in a plasmid vector for site specific arrhythmia gene therapy: In vitro and in vivo feasibility studies. Human Gene Therapy 14: 907-922, 2003.

Perlstein I, Connolly JM, Cui X, Song C, Li Q, Jones PL, Lu Z, DeFelice S, Klugherz B, Wilensky R, Levy RJ: DNA delivery from an intravascular stent with a denatured collagen polylactic-polyglycolic acid controlled release coating: Mechanisms of enhanced transfection. Gene Therapy 10: 1420-1428, 2003.

Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, Levy RJ, Labhasetwar V: Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. Journal of Controlled Release 92: 173-187, 2003.

Ghazvini-Boroujerdi M, Xu J, Jian B, Hazelwood S, Narula N, Levy RJ: Egr-1 is present in calcific aortic stenosis cusps. Transactions of the Society for Biomaterials 2003.

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Last updated: 07/23/2009
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