Steven M. Kawut, MD, MS
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Center for Clinical Epidemiology and Biostatistics
Perelman School of Medicine
718 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Perelman School of Medicine
718 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-0258
Fax: 215-573-5325
Fax: 215-573-5325
Email:
kawut@mail.med.upenn.edu
kawut@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Penn Lung Center - Pulmonary, Allergy and Critical Care Division
Pulmonary Vascular Disease Research Program
Search PubMed for articles
Penn Lung Center - Pulmonary, Allergy and Critical Care Division
Pulmonary Vascular Disease Research Program
Education:
AB (Biology)
Harvard College, Cambridge, MA, 1991.
MD (Medicine)
Yale School of Medicine, New Haven, CT, 1995.
MS (Clinical Epidemiology)
University of Pennsylvania School of Medicine, Philadelphia, PA, 2004.
Permanent linkAB (Biology)
Harvard College, Cambridge, MA, 1991.
MD (Medicine)
Yale School of Medicine, New Haven, CT, 1995.
MS (Clinical Epidemiology)
University of Pennsylvania School of Medicine, Philadelphia, PA, 2004.
Description of CVI Expertise
Director, Pulmonary Vascular Disease ProgramCVI Program Unit Administrator:
Pulmonary Vascular Disease
CVI Program Unit(s):
Pulmonary Vascular Disease
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Channel Biology / Electrophysiology
Thrombosis / Hemostasis
CVI Research Description:
The focus of my research group is the role of the pulmonary vasculature and right ventricular function in health and disease. We lead or contribute to epidemiologic studies and clinical trials of pulmonary arterial hypertension, idiopathic pulmonary fibrosis, COPD, and lung transplantation.
Specific projects include:
1. A clinical trial of aspirin and simvastatin for pulmonary arterial hypertension (ASA-STAT).
2. The Pulmonary Vascular Complications of Liver Disease (PVCLD) Study Group, which investigates the mechanisms and outcomes of hepatopulmonary syndrome and portopulmonary hypertension.
3. Endothelial dysfunction and the right ventricle in the Multi-Ethnic Study of Atherosclerosis (MESA-RV), focused on the determinants of right ventricular function in subjects without clinical cardiovascular disease.
4. Endothelial dysfunction, bio-markers, and lung function in the Multi-Ethnic Study of Atherosclerosis (MESA-Lung), focused on the relationship of lung function with cardiovascular and peripheral vascular function.
5. The Lung Transplant Outcomes Group, which is examining the role of pulmonary vascular dysfunction in primary graft dysfunction.
Selected Publications
Shah RJ, Bellamy SL, Localio AR, Wickersham N, Diamond JM, Weinacker A, Lama VN, Bhorade S, Belperio JA, Crespo M, Demissie EJ, Kawut SM, Wille KM, Lederer DJ, Lee JC, Palmer SM, Orens J, Reynolds J, Shah A, Wilkes DS, Ware LB*, Christie JD* : A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. J Heart Lung Transplant 31(9): 942-9, September 2012.Diamond JM, Meyer NJ, Feng R, Rushefski M, Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group: Variation in PTX3 is associated with primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med 186(6): 546-552, September 2012.
Gabler NM, French B, Strom BL, Palevsky HI, Taichman DB, Kawut SM, Halpern SD: Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials. Circulation 126(3): 349-56, Jul 2012.
Bastarache JA, Diamond JM, Kawut SM, Lederer DJ, Ware LB, Christie JD: Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients. Gend Med 9(3): 154-65, June 2012.
Carroll R, Antigu J, Taichman D, Palevsky H, Forfia P, Kawut SM, Halpern SD: Motivations of patients with pulmonary arterial hypertension to participate in randomized clinical trials. Clin Trials 9(3): 348-57, June 2012.
Lederer DJ, Bartels MN, Schluger NW, Brogan F, Jellen P, Thomashow BM, Kawut SM: Sildenafil for chronic obstructive pulmonary disease: A randomized crossover trial. COPD 9(3): 268-75, June 2012.
Barr RG, Ahmed FS, Carr JJ, Hoffman EA, Jiang R, Kawut SM, Watson KE: Subclinical atherosclerosis, airflow obstruction and emphysema: The MESA Lung Study. Eur Respir J 39(4): 846-54, April 2012.
Ventetuolo CE, Barr RG, Bluemke DA, Jain A, Delaney JAC, Hundley WG, Lima JAC, Kawut SM: Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: The MESA-Right Ventricle Study. PloS One 7(2): e30480, February 2012.
Hook JL, Arcasoy SM, Zemmel D, Bartels M, Kawut SM, Lederer DJ : Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J 39(2): 359-65, February 2012.
Chahal H, McClelland RL, Tandri H, Jain H, Turkbey EB, Hundley WG, Barr RG, Kizer J, Lima JAC, Bluemke DA, Kawut SM: Obesity and right ventricular structure and function: the MESA-right ventricle study. Chest 141(2): 388-95, February 2012.