Steven M. Kawut, MD, MS
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
718 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
University of Pennsylvania School of Medicine
718 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-0258
Fax: 215-573-5325
Fax: 215-573-5325
Email:
kawut@mail.med.upenn.edu
kawut@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Pulmonary Vascular Disease Research Program
Penn Lung Center - Pulmonary, Allergy and Critical Care Division
Search PubMed for articles
Pulmonary Vascular Disease Research Program
Penn Lung Center - Pulmonary, Allergy and Critical Care Division
Education:
AB (Biology)
Harvard College, Cambridge, MA, 1991.
MD (Medicine)
Yale School of Medicine, New Haven, CT, 1995.
MS (Clinical Epidemiology)
University of Pennsylvania School of Medicine, Philadelphia, PA, 2004.
Permanent linkAB (Biology)
Harvard College, Cambridge, MA, 1991.
MD (Medicine)
Yale School of Medicine, New Haven, CT, 1995.
MS (Clinical Epidemiology)
University of Pennsylvania School of Medicine, Philadelphia, PA, 2004.
Description of CVI Expertise
Director, Pulmonary Vascular Disease ProgramCVI Program Unit Administrator:
Pulmonary Vascular Disease
CVI Program Unit(s):
Pulmonary Vascular Disease
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Channel Biology / Electrophysiology
Thrombosis / Hemostasis
CVI Research Description:
The focus of my research group is the role of the pulmonary vasculature and right ventricular function in health and disease. We lead or contribute to epidemiologic studies and clinical trials of pulmonary arterial hypertension, idiopathic pulmonary fibrosis, COPD, and lung transplantation.
Specific projects include:
1. A clinical trial of aspirin and simvastatin for pulmonary arterial hypertension (ASA-STAT).
2. The Pulmonary Vascular Complications of Liver Disease (PVCLD) Study Group, which investigates the mechanisms and outcomes of hepatopulmonary syndrome and portopulmonary hypertension.
3. Endothelial dysfunction and the right ventricle in the Multi-Ethnic Study of Atherosclerosis (MESA-RV), focused on the determinants of right ventricular function in subjects without clinical cardiovascular disease.
4. Endothelial dysfunction, bio-markers, and lung function in the Multi-Ethnic Study of Atherosclerosis (MESA-Lung), focused on the relationship of lung function with cardiovascular and peripheral vascular function.
5. The Lung Transplant Outcomes Group, which is examining the role of pulmonary vascular dysfunction in primary graft dysfunction.
Selected Publications
Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama V, Shah PD, Orens JB, Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, Ware LB: Effect of single versus bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis. Chest 2011 [e-pub ahead of print) Notes: PMID: 21349925.Kawut SM, Bagiella E, Lederer D, Shimbo D, Horn EM, Roberts KE, Barr RG, Rosenzweig E, Post W, Palevsky HI, Tracy R, Hassoun PM, Girgis RE on behalf of the ASA-STAT Study Group: A randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT. Circulation 2011 [Epub ahead of print] Notes: PMID: 21593252.
Lederer DJ, Kawut SM, Wickersham N, WInterbottom C, Bhorade S, Palmer SM, Lee J Diamond JM, Willie KM, Weinacker A, Lama VN, Crespo M, Orens JB, Sonett JR, Arcasoy SM, Ware LB and Christie JD for the Lung Transplant Outcomes Group, Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study: Obesity and primary graft dysfunction after lung transplantation: the LTOG Obesity Study. Am J Respir Crit Care Med 2011 (In press).
Hook JL, Arcasoy SM, Zemmel D, Bartels M, Kawut SM, Lederer DJ : Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J 2011 (In press).
Barr RG, Ahmed FS, Carr JJ, Hoffman EA, Jiang R, Kawut SM, Watson KE: Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study. Eur Respir J 2011 (In Press).
Chahal H, McClelland RL, Tandri H, Jain H, Turkbey EB, Hundley WG, Barr RG, Kizer J, Lima JAC, Bluemke DA, Kawut SM: Obesity and right ventricular structure and function: the MESA-right ventricle study. Chest 2011 (In Press).
Diamond JM, Lederer D, Kawut SM, Lee J, Cantu E, Ahya V, Bellamy S, Palmer S, Lama V, Bhorade S, Crespo M, Demissie EJ, Sonett J, Wille K, Orens JB, Shah PD, Weinacker A, Weill D, Kohl B, Deutschman C, Arcasoy S, Shah A, Belperio J, Wilkes D, Reynolds JM, Ware L and Christie JD for the Lung Transplant Outcomes Group: Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. Am J Transpl 2011 (In Press).
Gabler NB, French B, Strom BL, Liu Z, Palevsky HI, Taichman DB, Kawut SM, Halpern SD: Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest 2011 (In Press).
Ventetuolo CE, Barr RG, Bluemke DA, Jain A, Delaney JAC, Hundley WG, Lima JAC, Kawut SM: Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: The MESA-Right Ventricle Study. PloS One 2011 (In Press).
Sildenafil for chronic obstructive pulmonary disease: a randomized crossover trial: Lederer DJ, Bartels MN, Schluger NW, Brogan F, Jellen P, Thomashow BM, Kawut SM COPD 2011 (In Press).
| Protocol | Title | Status |
|---|---|---|
| 807771 | A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension | Recruiting |