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Peter S. Klein, MD, PhD

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
9-103 Smilow Center for Translational Research (SCTR)
Perelman School of Medicine at the University of Pennsylvania
3400 Civic Center Blvd.
Philadelphia, PA 19104-5157
Office: 215-573-2931
Education:
B.A. (Biochemistry)
Harvard College, 1980.
M.D. (Medicine)
Johns Hopkins University School of Medicine, 1988.
Ph.D. (Biological Chemistry)
Johns Hopkins University School of Medicine, 1988.
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Selected Publications

Valvezan AJ, Huang J, Lengner CJ, Pack M, and PS Klein: Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease Models and Mechanisms 7(1): 63-71, Jan 2014.

Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, and PS Klein, : Maintenance of Hematopoietic Stem Cells through regulation of Wnt and mTOR Pathways. Nature Medicine 18: 1778-1785, Nov 11 2012 Notes: doi: 10.1038/nm.2984.

Valvezan AJ, Zhang FS, Diehl JA, and PS Klein: Adenomatous Polyposis Coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. Journal of Biological Chemistry 287: 3823-3832, 2012.

Skirkanich J, Luxardi G, Yang J, Kodjabachian L, and PS Klein: An essential role for transcription before the MBT in Xenopus laevis. Developmental Biology 357: 478-491, 2011.

O’Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, and PS Klein: Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. Journal of Clinical Investigation 121: 3756-3762, 2011.

Blythe SA and Klein PS: Prepatterning embryonic development: tabula scripta? Developmental Cell 21: 977-978, 2011.

Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS,: beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Developmental Cell 19(2): 220-231, Aug 2010.

Mazumdar J, O'Brien WT, Johnson RS, LaManna JC, Chavez JC, Klein PS, Simon MC: O2 regulates stem cells through Wnt/β-catenin signalling. Nature Cell Biology 12(10): 1007-13, Oct 2010.

Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS: Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. Journal of Clinical Investigation 119(12): 3519-29, Dec 2009.

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Last updated: 09/29/2017
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