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Anna Kashina, Ph.D.

Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
University of Pennsylvania
School of Veterinary Medicine
Department of Biomedical Sciences
3800 Spruce St., Rm. 143 Rosenthal
Philadelphia, PA 19104
Office: 215 746-0895
Fax: 215 573-5189
Education:
BS (Biochemistry)
Moscow State University, 1986.
MS (Biochemistry)
Moscow State University, 1987.
PhD (Cell Biology)
Moscow Institute for Protein Research, 1993.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure
Thrombosis / Hemostasis
Pulmonary

CVI Research Description:
We are working on the role of a poorly understood posttranslational modification -- arginylation -- in cardiovascular development. Arginylation is mediated by arginyltransferase Ate1. Its knockout leads to embryonic lethality in mice and severe cardiovascular defects. My lab is focused on uncovering the underlying mechanisms of these defects on the molecular, cellular, and organizmal levels.

Selected Publications

Wang, J., Han, X., Leu, N. A., Sterling, S., Kurosaka, S., Fina, M., Lee, V. M., Dong, D. W., Yates, J. R., Kashina, A.: Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Sci Rep 7(1): 11323, 2017.

Efimova, N., Korobova, F., Stankewich, M. C., Moberly, A. H., Stolz, D. B., Wang, J., Kashina, A., Ma, M., Svitkina, T.: βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. J Neurosci 37(27): 6442-6459, 2017.

Rai, R., Zhang, F., Colavita, K., Leu, N. A., Kurosaka, S., Kumar, A., Birnbaum, M. D., Győrffy, B., Dong, D. W., Shtutman, M., Kashina, A.: Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. Oncogene 35(31): 4058-4068, 2016.

Leite, F. D. S., Kashina, A., Rassier, D. E.: Posttranslational Arginylation Regulates Striated Muscle Function. Exerc Sport Sci Rev 44(3): 98-103, 2016.

Leite, F. S., Minozzo, F. C., Kalganov, A., Cornachione, A. S., Cheng, Y. S., Leu, N. A., Han, X., Saripalli, C., Yates, J. R., Granzier, H., Kashina, A. S., Rassier, D. E.: Reduced passive force in skeletal muscles lacking protein arginylation. Am J Physiol Cell Physiol 310(2): C127-C135, 2016.

Zhang, F., Patel, D. M., Colavita, K., Rodionova, I., Buckley, B., Scott, D. A., Kumar, A., Shabalina, S. A., Saha, S., Chernov, M., Osterman, A. L., Kashina, A.: Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Nat Commun 6: 7517, 2015.

Leite, F. D. S., Minozzo, F. C., Trecarten, N., Han, X., Yates, J. R., Kashina, A., Rassier, D. E.: Passive Force Analysis of Single Sarcomeres from Muscles Lacking Arginyl-tRNA-Protein Transferase (Ate1). Biophys J 108(2): 591A-591A, 2015.

Saha, S., Wang, J., Kashina, A. S.: High-Throughput Arginylation Assay in Microplate Format. Methods Mol Biol 1337: 79-82, 2015.

Wang, J., Kashina, A. S.: Bacterial Expression and Purification of Recombinant Arginyltransferase (ATE1) and Arg-tRNA Synthetase (RRS) for Arginylation Assays. Methods Mol Biol 1337: 67-71, 2015.

Wang, J., Kashina, A. S.: Assaying ATE1 Activity In Vitro. Methods Mol Biol 1337: 73-77, 2015.

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Last updated: 01/08/2018
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