Associate Director, Cardiovascular Imaging
CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
CVI Research Description:
1. Ventricular remodeling
Characterization of the right and/or left ventricular response to pulmonary hypertension, infarction, and valvular disease using MRI, echocardiography and PET/SPECT techniques in pre-clinical models and clinical disease states.
2. Developmental cardiology
Assessment of cardiac morphology and function using MRI and echocardiography including slp-76, HOP, and N-cadherin transgenic models. Use of MRI, CT, and echo in the evaluation of adult congenital heart disease.
3. Stem cell tracking
Evaluation of stem cell localization after intravenous injection or intracardiac implantation of stem cells co-labeled using MRI and PET ligands. Assessment of stem cell survival and myocardial viability/function following stem cell treatment of post-infarction or other cardiomyopathies.
4. Plaque characterization
Evaluation of MRI and PET techniques for assessment of atherosclerosis in pre-clinical models of disease.
Kook H, Lepore J, Gitler AD, Lu MM, Ytung WW, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest
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Abtahian F, Guerriero A, Sebzda E, Lu M, Zhou R, Mocsai A, Myers EE, Huang B, Jackson D, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML: Regulation of blood and lymphatic separation by signaling proteins SLP-76 and Syk. Science 299: 247-251, 2003.
Arcasoy SM, Christie JD, Ferrari VA, St. John Sutton M, Zisman DA, Blumenthal NP, Pochettino A, and Kotloff RM: Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. American Journal of Respiratory and Critical Care Medicine 167: 735-740, 2003.
Zhou R, Pickup S, Scott CS, Glickson JD, Ferrari VA: Assessment of global and regional myocardial function in the mouse using cine- and tagged MRI. Magnetic Resonance in Medicine 49(4): 760-764, 2003.
Bluemke D, Krupinski EA, Ovitt T, Gear K, Unger E, Axel L, Boxt L, Casolo G, Ferrari VA, Funaki B, Globits S, Higgins CB, Julsrud P, Lipton M, Mawson J, Nygren A, Pennell DJ, Stillman A, White RD, Wichter T, Marcus F: Imaging of arrhythmogenic right ventricular cardiomyopathy: Morphologic findings and interobserver variability. Cardiology 99(3): 153-162, 2003.
Zhou R, Kahn ML, Ferrari VA: Detection of high output state by MRI in SLP-76 deficient mice leads to identification of unique angiogenic defect. Journal of Cardiovascular Magnetic Resonance 5(1): 216, 2003.
Ferrari VA, Matulevicius S, Axel L, Scott CH, Ksiezycka E, Duffy K, St. John Sutton M: ACE inhibitors stabilize LV remodeling despite persistently abnormal resting mechanics. Journal American College Cardiology 41(6): 442A, 2003.
Zhou R, Acton PD, Ferrari VA: Imaging stem cells implanted in infarcted myocardium. Journal of the American College of Cardiology 48: 2094-2106, 2006.
Tandri H, Castillo E, Ferrari VA, Nasir K, Dalal D, Bomma C, Calkins H, Bluemke DA: MR imaging of arrhythmogenic right ventricular dysplasia: Sensitivity, specificity, and observer variability of fat detection vs. functional analysis of the right ventricle. Journal of the American College of Cardiology 48: 2277-2284, December 2006.
Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CA, Gruber PJ, Epstein JA: Hdac2 regulates the cardiac hypertrophic response by modulating GSk3ß activity. Nature Medicine 13(3): 324-331, March 2007.
Correa CR, Litt HI, Hwang WT, Ferrari VA, Solin LJ, Harris EE.: Coronary artery findings after left-sided versus right-sided radiation treatment for early breast cancer. Journal of Clinical Oncology 25(21): 3031-3037, July 2007.
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Last updated: 04/18/2016
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