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Vladimir R. Muzykantov, MD, PhD

Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
10-105 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-5158
Office: 215-898-9823
Fax: 215-898-0868
Education:
M.D. (Internal Medicine)
First School of Medicine, Moscow, Russia, 1980.
Ph.D. (Biochemistry)
National Cardiology Research Center, Moscow, Russia, 1985.
M.A. (Honoris Causa)
University of Pennsylvania, 2004.
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Description of CVI Expertise

CVI Program Unit(s):
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
Dr. Muzykantov focuses on targeted drug delivery to the endothelium and blood cells for treatment of thrombosis, ischemia and other cardiovascular maladies. He also teaches cardiovascular biology to graduate students in pharmacology.

Selected Publications

Brenner Jacob S, Pan Daniel C, Myerson Jacob W, Marcos-Contreras Oscar A, Villa Carlos H, Patel Priyal, Hekierski Hugh, Chatterjee Shampa, Tao Jian-Qin, Parhiz Hamideh, Bhamidipati Kartik, Uhler Thomas G, Hood Elizabeth D, Kiseleva Raisa Yu, Shuvaev Vladimir S, Shuvaeva Tea, Khoshnejad Makan, Johnston Ian, Gregory Jason V, Lahann Joerg, Wang Tao, Cantu Edward, Armstead William M, Mitragotri Samir, Muzykantov Vladimir: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude. Nat Commun 9(1): 2684, Jul 2018.

Myerson Jacob W, Braender Bruce, Mcpherson Olivia, Glassman Patrick M, Kiseleva Raisa Y, Shuvaev Vladimir V, Marcos-Contreras Oscar, Grady Martha E, Lee Hyun-Su, Greineder Colin F, Stan Radu V, Composto Russell J, Eckmann David M, Muzykantov Vladimir R: Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles. Adv Mater Page: e1802373, Jun 2018.

Khoshnejad Makan, Greineder Colin F, Pulsipher Katherine W, Villa Carlos H, Altun Burcin, Pan Daniel C, Tsourkas Andrew, Dmochowski Ivan J, Muzykantov Vladimir R: Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging. Bioconjug Chem 29(4): 1209-1218, Apr 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2(3): 165-176, Feb 2018.

Shuvaev Vladimir V, Kiseleva Raisa Yu, Arguiri Evguenia, Villa Carlos H, Muro Silvia, Christofidou-Solomidou Melpo, Stan Radu V, Muzykantov Vladimir R: Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin. J Control Release 272: 1-8, Feb 2018.

Khoshnejad Makan, Brenner Jacob S, Motley William, Parhiz Hamideh, Greineder Colin F, Villa Carlos H, Marcos-Contreras Oscar A, Tsourkas Andrew, Muzykantov Vladimir R: Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9. Sci Rep 8(1): 1760, Jan 2018.

Greineder Colin F, Villa Carlos H, Walsh Landis R, Kiseleva Raisa Y, Hood Elizabeth D, Khoshnejad Makan, Warden-Rothman Robert, Tsourkas Andrew, Muzykantov Vladimir R: Site-Specific Modification of Single-Chain Antibody Fragments for Bioconjugation and Vascular Immunotargeting. Bioconjug Chem 29(1): 56-66, Jan 2018.

Kiseleva Raisa Yu, Greineder C F, Villa C H, Marcos-Contreras O A, Hood E D, Shuvaev V V, DeLisser H M, Muzykantov V R: Vascular endothelial effects of collaborative binding to platelet/endothelial cell adhesion molecule-1 (PECAM-1). Sci Rep 8(1): 1510, Jan 2018.

Pan Daniel C, Myerson Jacob W, Brenner Jacob S, Patel Priyal N, Anselmo Aaron C, Mitragotri Samir, Muzykantov Vladimir: Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells. Sci Rep 8(1): 1615, Jan 2018.

Kartha Sonia, Yan Lesan, Weisshaar Christine L, Ita Meagan E, Shuvaev Vladimir V, Muzykantov Vladimir R, Tsourkas Andrew, Winkelstein Beth A, Cheng Zhiliang: Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain. Adv Healthc Mater 6(17), Sep 2017.

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Last updated: 08/14/2018
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