Vladimir R. Muzykantov
Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Institute for Environmental Medicine (IFEM)
1 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6068
1 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6068
Office: 215-898-9823
Fax: 215-898-0868
Fax: 215-898-0868
Email:
muzykant@mail.med.upenn.edu
muzykant@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Primary Work Website
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Primary Work Website
Education
M.D. (Internal Medicine)
First School of Medicine, Moscow, Russia, 1980.
Ph.D. (Biochemistry)
National Russian Cardiology Research Center, RCRC, Moscow, 1985.
Permanent linkM.D. (Internal Medicine)
First School of Medicine, Moscow, Russia, 1980.
Ph.D. (Biochemistry)
National Russian Cardiology Research Center, RCRC, Moscow, 1985.
Description of CVI Expertise
CVI Program Unit(s):Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis
CVI Research Description:
Dr. Muzykantov focuses on targeted drug delivery to the endothelium and blood cells for treatment of thrombosis, ischemia and other cardiovascular maladies. He also teaches cardiovascular biology to graduate students in pharmacology.
Selected Publications
Ding B-S, Hong N, Murciano J-C, Ganguly, K, Gottstein C, Christofidou-Solomidou M, Albelda SM, Fisher AB, Cines DB, Muzykantov VR: Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature. Blood 111: 1999-2006, 2008.Garnacho C, Dhami R, Simone E, Dziubla T, Leferovich J, Schuchman Edward H. Muzykantov V, Muro S: Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers. J Pharm Exper Ther 325: 400-408, 2008.
Garnacho C, Shuvaev V, Thomas A, McKenna L, Sun J, Koval M, Albelda S, Muzykantov V, Muro S: RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood 111: 3024-3033, 2008.
Rossin R, Muro S, Welch MJ, Muzykantov VR, Schuster DP: In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium. J Nucl Med 49: 103-111, 2008.
Dziubla TD, Shuvaev VV, Hong NK, Hawkins BJ, Madesh M, Takano H, Simone E, Nakada MT, Fisher A, Albelda SM, Muzykantov VR: Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies. Biomaterials 29: 215-227, 2008.
Simone EA, Dziubla TD, Colon-Gonzalez F, Discher DE, Muzykantov VR: Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers. Biomacromolecules 8: 3914-3921, 2007.
Ganguly K, Murciano J-. Westrick R, Leferovich J, Cines DB, Muzykantov VR: The glycocalyx protects erythrocyte-bound tissue-type plasminogen activator from enzymatic inhibition. J Pharmacol Exper Therap 321: 158-64, 2007.
Shuvaev VV, Christofidou-Solomidou M, Scherpereel A, Simone E, Arguiri E, Tliba S, Pick J, Kennel S, Albelda SM, Muzykantov VR: Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium. J Controlled Release 118: 235-244, 2007.
Danielyan K, Ding B, Gottstein C, Cines DB, Muzykantov VR: Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema. J Pharmacol Exper Therap 321: 947-52, 2007.
Shuvaev VV, Tliba S, Nakada M, Albelda SM, Muzykantov VR: Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular superoxide. J Pharm ExperTher 323: 450-457, 2007.
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