Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Muredach P. Reilly, MBBCH, MSCE

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Center
3400 Civic Center Blvd, Bldg 421
11th Floor, Room 11-136
Philadelphia, PA 19104
Office: (215) 573-1214
Lab: (215) 573-0224
MBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
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Description of CVI Expertise

CVI Program Unit(s):

CVI Research Description:
Dr. Reilly has extensive training and expertise in cardiovascular medicine, preventive cardiology, clinical pharmacology, epidemiology and translational research.

His interests include (1) mechanisms of atherosclerosis in metabolic syndrome, diabetes and obesity, (2) the role on innate immunity in promoting atherosclerotic risk in metabolic syndrome, (3) the functions of adipose tissue in regulation of HDL cholesterol and reverse cholesterol transport, (4) genetics of atherosclerosis and dyslipidemia in high risk populations including type 2 diabetes, subjects with family history of CAD, populations with chronic kidney disease and in HIV infected populations, and (5) non-invasive imaging of atherosclerosis in humans.

Dr. Reilly employs a translational approach to his research including cell and animal based mechanistic studies, mechanistic patient-oriented, General Clinical Research Center studies as well as larger scale epidemiological studies in humans.

Selected Publications

Schick UM, Auer PL, Bis JC, Lin H, Wei P, Pankratz N, Lange LA, Brody J, Stitziel NO, Kim DS, Carlson CS, Fornage M, Haessler J, Hsu L, Jackson RD, Kooperberg C, Leal SM, Psaty BM, Boerwinkle E, Tracy R, Ardissino D, Shah S, Willer C, Loos R, Melander O, Mcpherson R, Hovingh K, Reilly M, Watkins H, Girelli D, Fontanillas P, Chasman DI, Gabriel SB, Gibbs R, Nickerson DA, Kathiresan S, Peters U, Dupuis J, Wilson JG, Rich SS, Morrison AC, Benjamin EJ, Gross MD, Reiner AP: Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Hum Mol Genet 24((2)): 559 -71, Jan 2015 Notes: Cohorts for Heart and Aging Research in Genomic Epidemiology and the National Heart, Lung, and Blood Institute GO Exome Sequencing Project.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MG. : The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis. Clin J Am Soc Nephrol. 10(11): 1911-20, Nov 2015.

CARDIoGRAMplusC4D Consortium. : A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 47(10): 1121-30, Oct 2015.

Skarke C, Alamuddin N, Lawson JA, Li X, Ferguson JF, Reilly MP, FitzGerald GA. : Bioactive products formed in humans from fish oils. J Lipid Res. 56(9): 1808-20, Sep 2015.

Churchill TW, Rasania SP, Rafeek H, Mulvey CK, Terembula K, Ferrari V, Jha S, Lilly SM, Eraso LH, Reilly MP, Qasim AN. : Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus. J Cardiovasc Comput Tomogr. 9(5): 373-81, Sep-Oct 2015.

Shah R, O'Neill SM, Hinkle C, Caughey J, Stephan S, Lynch E, Bermingham K, Lynch G, Ahima RS, Reilly MP. : Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice. PLoS One. 10(9): e0138317, Sep 2015.

Lin JJ, Zhang X, Xue C, Zhang H, Shashaty MG, Gosai S, Meyer NJ, Grazioli A, Hinkle C, Caughey J, Li W, Susztak K, Gregory BD, Li M, Reilly MP.: The Long Noncoding RNA Landscape in Hypoxic and Inflammatory Renal Epithelial Injury. Am J Physiol Renal Physiol. ajprenal.00290.2015. Sep 2015.

Shah R, Matthews GJ, Shah RY, McLaughlin C, Chen J, Wolman M, Master SR, Chai B, Xie D, Rader DJ, Raj DS, Mehta NN, Budoff M, Fischer MJ, Go AS, Townsend RR, He J, Kusek JW, Feldman HI, Foulkes AS, Reilly MP; CRIC Study Investigators. : Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 66(2): 266-73, Aug 2015.

Jansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E, Hengstenberg C, Laaksonen R, McPherson R, Roberts R, Thorsteinsdottir U, Peters A, Gieger C, Rawal R, Thompson JR, König IR; CARDIoGRAM consortium, Vasan RS, Erdmann J, Samani NJ, Schunkert H. : Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 241(2): 419-26, Aug 2015.

Christofidou P, Nelson CP, Nikpay M, Qu L, Li M, Loley C, Debiec R, Braund PS, Denniff M, Charchar FJ, Arjo AR, Trégouët DA, Goodall AH, Cambien F, Ouwehand WH, Roberts R, Schunkert H, Hengstenberg C, Reilly MP, Erdmann J, McPherson R, König IR, Thompson JR, Samani NJ, Tomaszewski M. : Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages. Am J Hum Genet. 97(2): 228-37, Aug 2015.

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Last updated: 11/22/2015
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