Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Muredach P. Reilly, MBBCH, MSCE

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Center
3400 Civic Center Blvd, Bldg 421
11th Floor, Room 11-136
Philadelphia, PA 19104
Office: (215) 573-1214
Lab: (215) 573-0224
MBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
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Description of CVI Expertise

CVI Program Unit(s):

CVI Research Description:
Dr. Reilly has extensive training and expertise in cardiovascular medicine, preventive cardiology, clinical pharmacology, epidemiology and translational research.

His interests include (1) mechanisms of atherosclerosis in metabolic syndrome, diabetes and obesity, (2) the role on innate immunity in promoting atherosclerotic risk in metabolic syndrome, (3) the functions of adipose tissue in regulation of HDL cholesterol and reverse cholesterol transport, (4) genetics of atherosclerosis and dyslipidemia in high risk populations including type 2 diabetes, subjects with family history of CAD, populations with chronic kidney disease and in HIV infected populations, and (5) non-invasive imaging of atherosclerosis in humans.

Dr. Reilly employs a translational approach to his research including cell and animal based mechanistic studies, mechanistic patient-oriented, General Clinical Research Center studies as well as larger scale epidemiological studies in humans.

Selected Publications

Prenner SB, Mulvey CK, Ferguson JF, Rickels MR, Bhatt AB, Reilly MP.: Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis. 236(2): 244-250, July 2014.

Sean O'Neill, Christine Hinkle, Shu-Jen Chen, Arbansjit Sandhu, Ruben Hovhannisyan, Stephen Stephan, William Lagor, Rexford Ahima, Julie Johnston, and Muredach Reilly : Targeting adipose tissue via systemic gene therapy Gene Ther. 21(7): 653-661, July 2014.

Shashaty MG, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD.: Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients. Crit Care Med. 42(7): 1619-28, July 2014.

Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP; Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Lusis AJ, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL.: Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 10(7): e1004502, July 2014.

Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA; the Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP; the CARDIoGRAM Consortium, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ; the CHARGE Consortium Hemostatic Factor Working Group.: Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol. 34(5): 1093-101, May 2014.

Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A. : Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures. Am J Physiol Endocrinol Metab. 306(10): E1217-24, May 2014.

Mehta N, Qamar A, Qu L, Qasim AN, Mehta NN, Reilly MP, Rader DJ. : Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits. Arterioscler Thromb Vasc Biol. 34(5): 1057-63, May 2014.

Liu Y, Ferguson JF, Xue C, Ballantyne RL, Silverman IM, Gosai SJ, Serfecz J, Morley MP, Gregory BD, Li M, Reilly MP. : Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures of Cardiometabolic Diseases. Arterioscler Thromb Vasc Biol. 34(4): 902-12, April 2014.

Reilly JP, Meyer NJ, Shashaty MG, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena DN, Reilly MP, Christie JD. : ABO Blood Type A is Associated with Increased Risk of Acute Respiratory Distress Syndrome in Caucasians Following both Major Trauma and Severe Sepsis. Chest. 145(4): 753-61, April 2014.

Ferguson JF, Ryan M, Gibney E, Brennan L, Roche HM, Reilly MP.: Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers Nutr Metab Cardiovasc Dis. Page: S0939-4753, April 2014 Notes: pii: S0939-4753(14)00130-6. doi:

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Last updated: 09/18/2014
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