Muredach P. Reilly, MBBCH, MSCE
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Translational Research Center
3400 Civic Center Blvd, Bldg 421
11th floor, Room 11-136
Philadelphia PA 19104
Philadelphia, PA 19104
3400 Civic Center Blvd, Bldg 421
11th floor, Room 11-136
Philadelphia PA 19104
Philadelphia, PA 19104
Office: (215) 573-1214
Publications
Links
Search PubMed for articles
Cardiovascular Division Faculty
Penn Health Profile
Institute for Translational Medicine and Therapeutics
Search PubMed for articles
Cardiovascular Division Faculty
Penn Health Profile
Institute for Translational Medicine and Therapeutics
Education:
MBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
Permanent linkMBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
Description of CVI Expertise
CVI Program Unit(s):CVI Research Description:
Dr. Reilly has extensive training and expertise in cardiovascular medicine, preventive cardiology, clinical pharmacology, epidemiology and translational research.
His interests include (1) mechanisms of atherosclerosis in metabolic syndrome, diabetes and obesity, (2) the role on innate immunity in promoting atherosclerotic risk in metabolic syndrome, (3) the functions of adipose tissue in regulation of HDL cholesterol and reverse cholesterol transport, (4) genetics of atherosclerosis and dyslipidemia in high risk populations including type 2 diabetes, subjects with family history of CAD, populations with chronic kidney disease and in HIV infected populations, and (5) non-invasive imaging of atherosclerosis in humans.
Dr. Reilly employs a translational approach to his research including cell and animal based mechanistic studies, mechanistic patient-oriented, General Clinical Research Center studies as well as larger scale epidemiological studies in humans.
Selected Publications
Mehta NN, Li M, William D, Khera AV, Derohannessian S, Qu L, Ferguson JF, McLaughlin C, Shaikh LH, Shah R, Patel PN, Bradfield JP, He J, Stylianou IM, Hakonarson H, Rader DJ, Reilly MP. : The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J. 32(8): 963-71, March 2011 Notes: PMID: 21415067Budoff MJ, Rader DJ, Reilly MP, Mohler ER 3rd, Lash J, Yang W, Rosen L, Glenn M, Teal V, Feldman HI; CRIC Study Investigators. : Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis. 58(4): 519-26, Oct 2011.
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJ, Luan J, Makrilakis K, Manning AK, Martínez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stancáková A, Stirrups K, Swift AJ, Syvänen AC, Tuomi T, van 't Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B; DIAGRAM Consortium; GIANT Consortium; MuTHER Consortium; CARDIoGRAM Consortium; C4D Consortium, Ongen H, Mälarstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-Ríos M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Watkins H, Froguel P, Johnson P, Deloukas P, Collins FS, Laakso M, Dermitzakis ET, Boehnke M, McCarthy MI, Wareham NJ, Groop L, Pattou F, Gloyn AL, Dedoussis GV, Lyssenko V, Meigs JB, Barroso I, Watanabe RM, Ingelsson E, Langenberg C, Hamsten A, Florez JC. : Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 60(10): 2624-34, Oct 2011 Notes: PMID: 21873549
Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U, Post WS, Smith AV, Cupples LA, Markus HS, Schmidt R, Huffman JE, Lehtimäki T, Baumert J, Münzel T, Heckbert SR, Dehghan A, North K, Oostra B, Bevan S, Stoegerer EM, Hayward C, Raitakari O, Meisinger C, Schillert A, Sanna S, Völzke H, Cheng YC, Thorsson B, Fox CS, Rice K, Rivadeneira F, Nambi V, Halperin E, Petrovic KE, Peltonen L, Wichmann HE, Schnabel RB, Dörr M, Parsa A, Aspelund T, Demissie S, Kathiresan S, Reilly MP, Taylor K, Uitterlinden A, Couper DJ, Sitzer M, Kähönen M, Illig T, Wild PS, Orru M, Lüdemann J, Shuldiner AR, Eiriksdottir G, White CC, Rotter JI, Hofman A, Seissler J, Zeller T, Usala G, Ernst F, Launer LJ, D'Agostino RB Sr, O'Leary DH, Ballantyne C, Thiery J, Ziegler A, Lakatta EG, Chilukoti RK, Harris TB, Wolf PA, Psaty BM, Polak JF, Li X, Rathmann W, Uda M, Boerwinkle E, Klopp N, Schmidt H, Wilson JF, Viikari J, Koenig W, Blankenberg S, Newman AB, Witteman J, Heiss G, Duijn C, Scuteri A, Homuth G, Mitchell BD, Gudnason V, O'Donnell CJ; CARDIoGRAM Consortium. : Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet. 43(10): 940-7, Sep 2011 Notes: PMID: 21909108 doi: 10.1038/ng.920.
International Consortium for Blood Pressure Genome-Wide Association Studies. : Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478(7367): 103-9, Sep 2011 Notes: PMID: 21909115 doi: 10.1038/nature10405.
Liu CT, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Atkinson E, Ding J, Nalls M, Shriner D, Coresh J, Kutlar A, Bibbins-Domingo K, Siscovick D, Akylbekova E, Wyatt S, Astor B, Mychaleckjy J, Li M, Reilly MP, Townsend RR, Adeyemo A, Zonderman AB, de Andrade M, Turner ST, Mosley TH, Harris TB; CKDGen Consortium, Rotimi CN, Liu Y, Kardia SL, Evans MK, Shlipak MG, Kramer H, Flessner MF, Dreisbach AW, Goessling W, Cupples LA, Kao WL, Fox CS. : Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 7(9): e1002264, Sept 2011.
IBC 50K CAD Consortium.: Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet. 7(9): e1002260, Sept 2011 Notes: PMID:21966275
Ricketts SL, Rensing KL, Holly JM, Chen L, Young EH, Luben R, Ashford S, Song K, Yuan X, Dehghan A, Wright BJ, Waterworth DM, Mooser V; GEMS Investigators, Waeber G, Vollenweider P, Epstein SE, Burnett MS, Devaney JM, Hakonarson HH, Rader DJ, Reilly MP, Danesh J, Thompson SG, Dunning AM, van Duijn CM, Samani NJ, McPherson R, Wareham NJ, Khaw KT, Boekholdt SM, Sandhu MS. : Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. Int J Mol Epidemiol Genet. 2(3): 261-85, Aug 2011 Notes: PMID: 21915365
Martin SS, Qasim AN, Rader DJ, Reilly MP. : C-Reactive Protein Modifies the Association of Plasma Leptin With Coronary Calcium in Asymptomatic Overweight Individuals. Obesity (Silver Spring). Jul 2011 Notes: PMID: 21738237
Kanetsky PA, Mitra N, Vardhanabhuti S, Vaughn DJ, Li M, Ciosek SL, Letrero R, D'Andrea K, Vaddi M, Doody DR, Weaver J, Chen C, Starr JR, Håkonarson H, Rader DJ, Godwin AK, Reilly MP, Schwartz SM, Nathanson KL.: A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum Mol Genet. May 2011 Notes: [Epub ahead of print]PMID: 21551455
| Protocol | Title | Status |
|---|---|---|
| 804727 | A Pilot Study of Metabolic Effects of Low-Dose Endotoxemia(Clinical Protocol,Version date: July 17, 2006) | Recruiting |
| 706771 | Inflammation and the Metabolic Syndrome in Humans (Version 6.2, dated 12/21/2006) | Recruiting |
| 703615 | Penn Diabetes Heart Study (Protocol Amendment, version date 12/15/10 | Recruiting |
| 804384 | Genetics of Atherosclerosis in Renal Disease | Recruiting |
| 805670 | The Genetics of Evoked-Responses to Niacin and Endotoxemia: The GENE Study (Revised Protocol, version 2.3 12/01/2011) | Recruiting |