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Reed E. Pyeritz, MD, PhD

William Smilow Professor
Department: Medicine

Contact information
Division of Translational Medicine and Human Genetics
University of Pennsylvania School of Medicine
11-133 Smilow Center for Translational Research, 3400 Civic Center Blvd
Philadelphia, PA 19104-4283
Office: 215-662-4740
Fax: 215-614-0298
Lab: 215-573-5746
Education:
S.B. (Chemistry)
University of Delaware, 1968.
A.M, Ph.D. (Biological Chemistry)
Harvard University, 1972.
M.D.
Harvard Medical School, 1975.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease

CVI Research Description:
Involved in clinical and translational research in a variety of hereditary conditions that involve the cardiovascular system, especially Marfan syndrome, hereditary hemorrhagic telangiectasia and Ehlers-Danlos syndromes.

Selected Publications

Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, James M, Everett EM, Clancy MS, Faughnan ME, Oh SP, Olitsky SE, Pyeritz RE, Gossage JR : Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial. JAMA. 316(9): 943-951, Sep 2016.

Roman MJ, Pugh NL, Hendershot TP, Devereux RB, Dietz H, Holmes K, Eagle KA, LeMaire SA, Milewicz DM, Morris SA, Pyeritz RE, Ravekes WJ, Shohet RV, Silberbach M; GenTAC Investigators: Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). J Am Heart Assoc 5: 8, Aug 2016.

Bossone E, Pyeritz RE, Braverman AC, Peterson MD, Ehrlich M, O'Gara P, Suzuki T, Trimarchi S, Gilon D, Greason K, Desai ND, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA; IRAD Investigators.: Shock complicating type A acute aortic dissection: Clinical correlates, management, and outcomes. Am Heart J 176: 93-99, Jun 2016.

Weinsaft JW, Devereux RB, Preiss LR, Feher A, Roman MJ, Basson CT, Geevarghese A, Ravekes W, Dietz HC, Holmes K, Habashi J, Pyeritz RE, Bavaria J, Milewski K, LeMaire SA, Morris S, Milewicz DM, Prakash S, Maslen C, Song HK, Silberbach GM, Shohet RV, McDonnell N, Hendershot T, Eagle KA, Asch FM; GENTAC Registry Investigators. : Aortic Dissection in Patients With Genetically Mediated Aneurysms: Incidence and Predictors in the GenTAC Registry. J Am Coll Cardiol 67(23): 2744-2754, Jun 2016.

Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld PD, Klein GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, Paridon SM, Pemberton VL, Pierpont ME, Pyeritz RE, Radojewski E, Roman MJ, Sharkey AM, Stylianou MP, Wechsler SB, Young LT, Mahony L; Pediatric Heart Network Investigators: Atenolol versus losartan in children and young adults with Marfan's syndrome. N Engl J Med 371(22): 2061-2071, Nov 2014.

Pyeritz RE: What is the optimal medical therapy for Marfan syndrome? J Pediatr 165(5): 889-890, Nov 2014.

Dean JH, Woznicki EM, O'Gara P, Montgomery DG, Trimarchi S, Myrmel T, Pyeritz RE, Harris KM, Suzuki T, Braverman AC, Hughes GC, Kline-Rogers E, Nienaber CA, Isselbacher EM, Eagle KA, Bossone E: Cocaine-related aortic dissection: lessons from the International Registry of Acute Aortic Dissection. Am J Med 127(9): 878-885, Sep 2014.

Reiff M, Mueller R, Mulchandani S, Spinner NB, Pyeritz RE, Bernhardt BA: A qualitative study of healthcare providers' perspectives on the implications of genome-wide testing in pediatric clinical practice. J Genet Couns 23(4): 474-488, Aug 2014.

Hoff E, Eagle T, Pyeritz RE, Ehrlich M, Voehringer M, Bossone E, Hutchison S, Peterson MD, Suzuki T, Greason K, Forteza A, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA: Pulse pressure and type A acute aortic dissection in-hospital outcomes (from the International Registry of Acute Aortic Dissection). Am J Cardiol 113(y): 1255-1259, Apr 2014.

Cook JR, Carta L, BĂ©nard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P; GenTAC Registry Consortium, Costa KD, Hajjar RJ, Ramirez F : Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest 124(3): 1229-1339, Mar 2014.

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Last updated: 11/23/2016
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