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Jeffrey M. Bergelson, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
1202 Abramson
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-3771
Fax: (215) 590-2025
Education:

Columbia College, 1969.
A.B.
Harvard College, 1972.

University of Pennsylvania medical school, 1973.
(graduate student in molecular genetics)
Rockefeller University , 1977.
M.D.
University of Pennsylvania, 1981.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure

CVI Research Description:
We study the coxsackieiviruses, a major cause of viral myocarditis, with a focus on the role of receptors in pathogenesis. The major coxsackievirus receptor,CAR is a component of specialized intercellular junctions, including the intercalated disc of mature cardiomyocytes. CAR mediates homophilic and heterophilic cell adhesion, and work with some tumor cell lines suggests that CAR may transmit growth-inhibitory signals. We recently found that cardiomyocyte-specific deletion of the murine CAR gene results in embryonic death, with hyperplasia of the left wall of the embryonic heart, and malformation of sinuatrial valves. The CAR-deficient myocardial cells express N-myc, a compact layer marker, but do not express trabecular markers, such as BMP10 and ANF. We would like to define how CAR functions during cardiac development; specifically, the mechanism by which CAR influences the
formation of the normal ventricular wall.

Selected Publications

Bergelson JM, Shepley MP, Chan BMC, Hemler ME, Finberg RW : Identification of the integrin VLA-2 as a receptor for echovirus 1. Science 255: 1718-1720, 1992.

Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krikthivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW: Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275: 1320-1323, 1997.

Cohen CJ, Shieh JT-C, Pickles RJ, T Okegawa T, Hsieh J-T, Bergelson JM: The coxsackievirus and adenovirus receptor (CAR) is a transmembrane component of the tight junction. Proc. Natl. Acad. Sci. USA 98: 15192-15196, 2001.

Chen, Jin-Wen. Zhou, Bin. Yu, Qian-Chun. Shin, Sangyoon J. Jiao, Kai. Schneider, Michael D. Baldwin, H Scott. Bergelson, Jeffrey M.: Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circulation Research 98: 923-30, 2006.

Coyne CB, Bergelson JM: Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Cell 124: 119-131, 2006.

Coyne CB, Kim KS, Bergelson JM.: Poliovirus entry into human brain microvascular endothelial cells requires receptor-induced activation of the tyrosine phosphatase SHP-2. EMBO Journal 26: 4016–4028, 2007.

Bergelson JM, Shah S, Zaoutis T: Pediatric Infectious Diseases (A Volume in the Pediatric Requisites Series). Mosby, St. Louis, 2008.

Kallewaard Nicole L, Zhang Lili, Chen Jin-Wen, Guttenberg Marta, Sanchez Melissa D, Bergelson Jeffrey M: Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis. Cell host & microbe 6(1): 91-8, Jul 2009.

Bergelson Jeffrey M: Intercellular junctional proteins as receptors and barriers to virus infection and spread. Cell host & microbe 5(6): 517-21, Jun 2009.

Patel KP, Coyne CB, Bergelson JM: Dynamin- and lipid raft-dependent entry of DAF-binding and non-DAF-binding Coxsackieviruses into non-polarized cells. Journal of virology Aug 2009.

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Last updated: 06/19/2017
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