Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

J. Kevin Foskett, PhD

Isaac Ott Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
Department of Physiology
University of Pennsylvania
Perelman School of Medicine
700D Clinical Research Bldg./ 6085
Philadelphia, PA 19104
Office: (215) 898-1354
Fax: (215) 573-2273
Education:
B.S.
Duke University, 1974.
M.S.
University of South Carolina, 1977.
Ph.D.
University of California at Berkeley, 1981.
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Description of CVI Expertise

CVI Program Unit(s):
Channel Biology / Electrophysiology

CVI Research Description:
Calcium signaling; electrophysiology of inositol trisphosphate receptor Ca release channel; apoptosis; bioenergetics; molecular mechanisms of calcium uptake by mitochondria. Interest in moving all these areas into cardiovascular realm.

Selected Publications

Kevin Foskett J, Philipson B: The mitochondrial Ca2+ uniporter complex. J Mol Cell Cardiol. Elsevier Ltd. 78C: 3-8, Jan 2015.

Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M: LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. FASEB J. 28(11): 4936-49, Nov 2014 Notes: Available on 2015/11/1.

Vingtdeux V, Tanis JE, Chandakkar P, Zhao H, Dreses-Werringloer U, Campagne F, Foskett JK, Marambaud P: Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS One 9(11): e112484, Nov 2014.

Joseph, J. D., Y. Peng, MD, D.-O. D. Mak, K.-H. Cheung, H. Vais, J. K. Foskett and H. Wei: General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening. Anesthesiology 121(3): 528-37, Sept 2014.

149. Tordoff, M.G., H. T. Ellis, T. R. Aleman, A. Downing, P. Marambaud, J. K. Foskett, R. M. Dana and S. A. McCaughey: Salty Taste Deficits in CALHM1 Knockout Mice. Chemical Senses. Oxford University Press, 39(5): 515-28, Jul 2014.

Lee, R. J. and J. K. Foskett: Ca(2+) signaling and fluid secretion by secretory cells of the airway epithelium. Cell Calcium 55(6): 325-36, Jun 2014.

Shilling, D., M. Müller, H. Takano, D-O. D. Mak, T. Abel, D. A. Coulter and J. K. Foskett. : Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. Journal of Neuroscience 34(20): 6910-23, May 2014.

Taruno A, Matsumoto I, Ma Z, Marambaud P, Foskett JK.: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 35(12): 1111-8, Dec 2013.

Sung PJ, Tsai FD, Vais H, Court H, Yang J, Fehrenbacher N, Foskett JK, Philips MR.: Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors. Proceedings of the National Academy of Sciences of the United States of America 110(51): 20593-8, Dec 2013.

Mak DO, Vais H, Cheung KH, Foskett JK.: Nuclear patch-clamp electrophysiology of Ca2+ channels. Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press, 9: 885-91, Sep 2013 Notes: Cover Article.

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Last updated: 01/07/2015
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