Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

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J. Kevin Foskett, PhD

Isaac Ott Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
Department of Physiology
University of Pennsylvania
Perelman School of Medicine
700D Clinical Research Bldg./ 6085
Philadelphia, PA 19104
Office: (215) 898-1354
Fax: (215) 573-2273
Education:
B.S.
Duke University, 1974.
M.S.
University of South Carolina, 1977.
Ph.D.
University of California at Berkeley, 1981.
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Description of CVI Expertise

CVI Program Unit(s):
Channel Biology / Electrophysiology

CVI Research Description:
Calcium signaling; electrophysiology of inositol trisphosphate receptor Ca release channel; apoptosis; bioenergetics; molecular mechanisms of calcium uptake by mitochondria. Interest in moving all these areas into cardiovascular realm.

Selected Publications

149. Tordoff, M.G., H. T. Ellis, T. R. Aleman, A. Downing, P. Marambaud, J. K. Foskett, R. M. Dana and S. A. McCaughey: Salty Taste Deficits in CALHM1 Knockout Mice. Chemical Senses. Oxford University Press, 39(5): 515-28, Jul 2014.

Lee, R. J. and J. K. Foskett: Ca(2+) signaling and fluid secretion by secretory cells of the airway epithelium. Cell Calcium 55(6): 325-36, Jun 2014.

Shilling, D., M. Müller, H. Takano, D-O. D. Mak, T. Abel, D. A. Coulter and J. K. Foskett. : Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. Journal of Neuroscience 34(20): 6910-23, May 2014.

Joseph, J. D., Y. Peng, MD, D.-O. D. Mak, K.-H. Cheung, H. Vais, J. K. Foskett and H. Wei: General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening. Anesthesiology Page: E-Pub (ahead of print), 2014.

Taruno A, Matsumoto I, Ma Z, Marambaud P, Foskett JK.: How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel. Bioessays 35(12): 1111-8, Dec 2013.

Sung PJ, Tsai FD, Vais H, Court H, Yang J, Fehrenbacher N, Foskett JK, Philips MR.: Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors. Proceedings of the National Academy of Sciences of the United States of America 110(51): 20593-8, Dec 2013.

Mak DO, Vais H, Cheung KH, Foskett JK.: Nuclear patch-clamp electrophysiology of Ca2+ channels. Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press, 9: 885-91, Sep 2013 Notes: Cover Article.

Mak D.O., H. Vais, K.H. Cheung and J.K. Foskett: Patch clamp electrophysiology of intracellular Ca2+ channels. Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press, 9: 787-97, Sep 2013.

Mak D.O., H. Vais, K.H. Cheung and J.K. Foskett: Isolating nuclei from cultured cells for patch-clamp electrophysiology of intracellular Ca(2+) channels. Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press, 9: 880-4, Sep 2013.

Mak DO, Vais H, Cheung KH, Foskett JK.: Patch-clamp electrophysiology of intracellular Ca2+ channels. Calcium Techniques. M. D. Bootman, D. I. Yule and G. B. Bultynck (eds.). Cold Spring Harbor Laboratory Press, 9: 787-97, Sep 2013.

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Last updated: 06/24/2014
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