Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

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J. Kevin Foskett, PhD

Isaac Ott Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
Department of Physiology
University of Pennsylvania
School of Medicine
700D Clinical Research Bldg./ 6085
Philadelphia, PA 19104
Office: (215) 898-1354
Education:
B.S.
Duke University, 1974.
M.S.
University of South Carolina, 1977.
Ph.D.
University of California at Berkeley, 1981.
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Description of CVI Expertise

CVI Program Unit(s):
Channel Biology / Electrophysiology

CVI Research Description:
Calcium signaling; electrophysiology of inositol trisphosphate receptor Ca release channel; apoptosis; bioenergetics; molecular mechanisms of calcium uptake by mitochondria. Interest in moving all these areas into cardiovascular realm.

Selected Publications

Siebert Adam P, Ma Zhongming, Grevet Jeremy D, Demuro Angelo, Parker Ian, Foskett J Kevin: Structural and Functional Similarities of Calcium Homeostasis Modulator 1 (CALHM1) Ion Channel With Connexins, Pannexins and Innexins. The Journal of biological chemistry Jan 2013.

Mallilankaraman Karthik, Cárdenas César, Doonan Patrick J, Chandramoorthy Harish C, Irrinki Krishna M, Golenár Tünde, Csordás György, Madireddi Priyanka, Yang Jun, Müller Marioly, Miller Russell, Kolesar Jill E, Molgó Jordi, Kaufman Brett, Hajnóczky György, Foskett J Kevin, Madesh Muniswamy: MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism. Nature cell biology 14(12): 1336-43, Dec 2012.

Vais Horia, Foskett J Kevin, Ullah Ghanim, Pearson John E, Daniel Mak Don-On: Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating. The Journal of general physiology 140(6): 697-716, Dec 2012.

Mallilankaraman Karthik, Doonan Patrick, Cárdenas César, Chandramoorthy Harish C, Müller Marioly, Miller Russell, Hoffman Nicholas E, Gandhirajan Rajesh Kumar, Molgó Jordi, Birnbaum Morris J, Rothberg Brad S, Mak Don-On Daniel, Foskett J Kevin, Madesh Muniswamy: MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake that Regulates Cell Survival. Cell 151(3): 630-44, Oct 2012.

Kopil Catherine M, Siebert Adam P, Foskett J Kevin, Neumar Robert W: Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons. Journal of neurochemistry 123(1): 147-58, Oct 2012.

Lee Robert J, Foskett J Kevin: Why Mouse Airway Submucosal Gland Serous Cells Do Not Secrete Fluid in Response to cAMP Stimulation. The Journal of biological chemistry Sep 2012.

King J Darwin, Lee Jeffrey, Riemen Claudia E, Neumann Dietbert, Xiong Sheng, Foskett J Kevin, Mehta Anil, Muimo Richmond, Hallows Kenneth R: Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase. The Journal of biological chemistry 287(40): 33389-400, Sep 2012.

Ma Zhongming, Siebert Adam P, Cheung King-Ho, Lee Robert J, Johnson Brian, Cohen Akiva S, Vingtdeux Valérie, Marambaud Philippe, Foskett J Kevin: Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America 109(28): E1963-71, Jul 2012.

Shilling Dustin, Mak Don-On Daniel, Kang David E, Foskett J Kevin: Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. The Journal of biological chemistry 287(14): 10933-44, Mar 2012.

Vais Horia, Foskett J Kevin, Mak Don-On Daniel: InsP3R channel gating altered by clustering? Nature 478(7368): E1-2; discussion E2-3, Oct 2011.

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Last updated: 03/25/2014
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