Noam A. Cohen

faculty photo
Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Veteran's Administration Medical Center
Director, Rhinology Research, University of Pennsylvania, Department of Otorhinolaryngology
Chair of the Otorhinolaryngology Resident Research Committee, University of Pennsylvania Department of Otorhinolaryngology
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
UPHS, Department of ORL:HNS
3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104-4283
B.A. (Biology)
Johns Hopkins University , 1990.
M.D. (Medicine)
Johns Hopkins University , 1998.
Ph.D. (Neuroscience)
Johns Hopkins University , 1998.
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Description of Research Expertise

Upper airway mucosal innate immunity
Airway taste receptors
Respiratory cilia function
respiratory mucosal biofilms
Chronic Rhinosinusitis

Description of Itmat Expertise

Dr. Cohen's areas of investigation include inflammation induced respiratory cilia dysfunction, presence of bacterial biofilms in human sinonasal mucosa, inflammatory responses to mucosal biofilms, and utilization of recombinant innate immunity proteins topical therapies for treatment of CRS.

Selected Publications

Lee, R.J., Cohen, N.A.: Bitter Taste Bodyguards. Scientific American 314(2): 38-43, 2016.

Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Paschalis-Thomas D, Ischriopoulos H, Kriendler JL, Reed DR, Cohen NA: T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122(11): 4145-59, Oct 2012.

Lee, R.J., Kofonow, J.M., Rosen, P.L., Siebert, A.P., Chen, B., Doghramji, L., Xiong, G., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Kreindler, J.L., Margolskee, R.F., Cohen, N.A.: Bitter and sweet taste receptor regulation of human upper respiratory innate immunity. J Clin Invest 124(3): 1393-405, 2014.

Lee RJ, Workman AD, Carey RM, Chen B, Rosen PL, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA.: Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Sci Rep. 14(6): 33221, Sep 2016.

Adappa, N.D., Farquhar, D., Palmer, J.N., Kennedy, D.W., Doghramji, L., Morris, S.A., Owens, D., Mansfield, C., Lysenko, A., Lee, R.J., Cowart, B.J., Reed, D.R., Cohen, N.A.: TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6(1): 25-33. Jan 2016.

Stevens, W.W., Lee, R.J., Schleimer, R.P., Cohen, N.A.: Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol 136(6): 1442-53, Dec 2015.

Adappa, A.D., Howland, T.J., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lysenko, A., Reed, D.R., Lee, R.J., Cohen, N.A.: Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention. Int Forum of Allergy and Rhinology 3(3): 84-7, 2013.

Adappa, A.D., Zhang, Z., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lysenko, A., Reed, D.R., Scott, T., Zhao, N.W., Owens, D., Lee, R.J., Cohen, N.A.: The Bitter Taste Receptor T2R38 is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery. Int Forum of Allergy and Rhinology 4(1): 3-7, 2014.

Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA.: Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol. 6(8): 783-791, August 2016.

Douglas, J.E., Saunders, C.J., Reed, D.R., Cohen, N.A. : A role for airway taste receptor modulation in the treatment of upper respiratory infections. Expert Rev Respir Med. 10(2): 157-70, Feb 2016.

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Last updated: 04/05/2017
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