Marina A. Guvakova

faculty photo
Adjunct Assistant Professor of Surgery
Department: Surgery

Contact information
313 Stemmler Hall 37th Street and Hamilton Walk
Philadelphia, PA 19104
Office: 215-662-2449
Fax: 215-614-0765
Education:
M.Sc. (Biology with Highest Honors)
Novosibirsk State University, 1984.
Ph.D. (Cell Biology)
The Russian Academy of Sciences, Institute of Cytology and Genetics, 1992.
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Description of Research Expertise

RESEARCH INTERESTS:

molecular mechanisms of breast cancer;
association between breast cancer and melanoma;
IGF-I receptor: signaling and targeting;
cancer cell migration;
biomarkers of micro-invasive carcinomas;
multispectral imaging: quantitative image analysis

KEY WORDS:

cancer,receptor tyrosine kinase(RTK),IGF system,cell migration and invasion,adhesion receptors,cytoskeleton; image analysis

Description of Itmat Expertise

Dr. Guvakova's research is aimed at determining what signaling contributes to breast cancer cell migration and what molecules are the best targets for preventing the spread of cancer.

Selected Publications

Marina A Guvakova, William S.Y. Lee, Dana K Furstenau, Indira Prabakaran, David C. Li, Rupert Hung and Natasha Kushnir : The small GTPase Rap1 promotes cell movement rather than stabilizes adhesion in epithelial cells responding to insulin-like growth factor I Biochem. J. July 2014.

Marina A. Guvakova, YunQing Jiang, Indira Prabakaran, Fei Wan, Nandita Mitra, Douglas L. Fraker, Paul J. Zhang.: The quest for biomarkers of progressive DCIS using archived tissue. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B40. Oct 2013.

Prabakaran I,Grau, J.R.,Lewis R, Fraker D.L., and Guvakova M.A. : Rap2A is upregulated in invasive cells dissected from follicular thyroid cancer. Journal of Thyroid Research, Special Issue "Biomarkers in Thyroid Tumor Research: New Diagnostic Tools and Potential Targets of Molecular-Based Therapy" 2011, Oct 2011.

Furstenau D.K.,Mitra N.,Wan F. , Lewis R, Feldman M.D., Fraker D.L. , and Guvakova M.A.: Ras –related protein 1 and the insulin-like growth factor type I receptor are associated with risk of progression in patients diagnosed with carcinoma in situ Breast Cancer Research and Treatment 129(2): 361-372, Oct 2010.

Guvakova M.A., Lee W.S.Y.: Tuberin and Hamartin in Moving Breast Cancer Cells: Expression, Localization, and Function [ Open Access] Cell Movement: New Research Trends T. Abreu and G. Silva (eds.). NOVA Publishers, Page: chapter VI, pp.187-207, 2009 Notes: (book cover features graphics from this chapter).

Furstenau D.K., Mitra N. ,Wan F., Lewis R., Feldman M.D., Fraker D.L., and Guvakova M.A. : Upregulation of the small GTPase Rap1 and the insulin-like growth factor I receptor in breast epithelium occures in carcinoma in situ. Molecular Cancer Therapeutics 8(12 Suppl): A45, Dec 2009.

Guvakova,M.A.: Insulin-like growth factors control cell migration in health and disease [Review; 153 refs] International Journal of Biochemistry and Cell Biology 39(5): 890-909, May 2007 Notes: doi:10.1016/j.biocel.2006.10.013.

Lynch L., Vodyanik PI., Boettiger D., Guvakova MA.: Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells. Molecular Biology of the Cell 16(1): 51-63, Jan 2005.

Guvakova MA., Adams JC., Boettiger D.: Functional role of alpha-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells. Journal of Cell Science 115(Pt 21): 4149-65, Nov 1 2002.

Guvakova MA., Boettiger D., Adams JC.: Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor. International Journal of Biochemistry & Cell Biology 34(6): 685-98, Jun 2002.

Guvakova MA., Surmacz E.: The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. Experimental Cell Research 251(1): 244-55, Aug 25 1999.

Mauro L., Sisci D., Bartucci M., Salerno M., Kim J., Tam T., Guvakova MA., Ando S., Surmacz E.: SHC-alpha5beta1 integrin interactions regulate breast cancer cell adhesion and motility. Experimental Cell Research 252(2): 439-48, Nov 1 1999.

Salerno M., Sisci D., Mauro L., Guvakova MA., Ando S., Surmacz E.: Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cells. International Journal of Cancer 81(2): 299-304, Apr 12 1999.

Nolan MK., Jankowska L., Prisco M., Xu S., Guvakova MA., Surmacz E.: Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells. International Journal of Cancer 72(5): 828-34, Sep 4 1997.

Guvakova MA., Surmacz E.: Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells. Cancer Research 57(13): 2606-10, Jul 1 1997.

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Last updated: 07/28/2014
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