Angela Franciska Haczku

faculty photo
Research Associate Professor of Medicine
Investigator, Center of Excellence in Environmental Toxicology, University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Translational Research Laboratories
125 South 31st Street
Room 1209
Philadelphia, PA 19104
Office: (215) 573-4718
Fax: (215) 746-1224
Education:
M.D. (General Medicine)
University Medical School Debrecen, Hungary, 1986.
Ph.D. (Immunology)
University of London, United Kingdom, 1997.
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Description of Research Expertise

The lung has an immunoprotective, hyporesponsive environment that helps prevent inappropriate immune and inflammatory responses to inhaled toxic, infectious or allergenic material. The long-term goal of my research is to unravel the the mechanisms that impair the innate and adaptive immune crosstalk during development of allergic and infectious inflammatory changes in the lung. To investigate T-cell related pathologies such as the allergic airway response my laboratory has established various in vitro and in vivo (rodent) model systems suitable to study pulmonary inflammation as well as the resulting changes in lung physiology. My laboratory is one of the few that study the importance of the pulmonary surfactant and in particular, the lung collectins, (SP-A and SP-D), in asthma and chronic obstructive pulmonary disease. Our observations support the novel concept that these lectin-like innate immune molecules play an essential protective regulatory role during inflammatory changes. Our studies are important because they may provide unique, novel therapeutical opportunities to control and manipulate the immune system in the lung.
Keywords: pulmonary medicine, allergy and clinical immunology, asthma, airway inflammation, lung physiology, cell biology, animal models, tissue culture, molecular biology, pulmonary surfactant, T cells, cytokines

Description of Itmat Expertise

My laboratory was one of the few that originally raised the importance of lung collectins (SP-A and SP-D) in innate immune regulation of the inflammatory airway response in asthma and the one that discovered a feedback regulatory circuit between Th2 cytokines and SP-D. SP-D has a potent immunoprotective function and maybe used for therapeutic purposes in disease conditions such as COPD and cystic fibrosis where low SP-D levels worsen the outcome. We study the effects of air pollution (ozone exposure) on lung physiology and innate immune regulation of airway inflammation in asthma, COPD and influenza A virus infection. We are interested in the role of Fas ligand (death receptor) in apoptosis and of RELM-(resistin-like molecule) beta in extra cellular matrix deposition. We model social stress and cigarette smoke exposure in mice in vivo and study the alterations in lung epithelial and immune cell signaling networks, including glucocorticoid receptor related pathways.

Selected Publications

Sharma SK, Almeida FA, Kierstein S, Hortobagyi L, Lin T, Larkin A, Peterson J, Yagita H, Zangrilli JG, Haczku A: Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma. Allergy 67(3): 328-35, March 2012 Notes: Epub 2011 Dec 17.

Sziksz Erna; Vannay Adam; Haczku Angela: Galectin-9: a suppressor of food allergy? ALLERGY Volume: 67 (3): 293-295 March 2012.

Anderson AL, Zheng Y, Song D, LaRosa D, Van Rooijen N, Kierstein G, Kierstein S, Haczku A, Levinson AI: The B cell superantigen peptostreptococcus magnus protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins. Inflammation Research 61(2): 161-9, February 2012.

Haczku A: Innate immune regulation of asthma. Clin Exp Allergy 2012 Notes: Accepted for publication.

Qi Yang, Steven A. Saenz, Daniel A. Zlotoff, David Artis, Avinash Bhandoola: Natural Helper Cells Derive from Lymphoid Progenitors. The Journal of Immunology 187: 5505-9, Dec 2011.

Szabó E, Kovács I, Grune T, Haczku A, Virág L: PARP-1: a new player in the asthma field? Allergy 66(7): 811-814, July 2011.

S.K. Sharma, M. Fehrenbach, B. Ducka, S. Kierstein, C. Koziol-White, G. Wu, A. Haczku: Chronic Inflammation Is Associated With Increased Resistin-Like Molecule (RELM)-Beta Expression In Surfactant Protein D (SP-D) Knockout Mice. American Journal of Respiratory and Critical Care Medicine 183: A2770, May 2011 Notes: Oral Presentation; ATS 2011 Denver, CO.

J. Rajaei, K. Emami, Y. Xin, S. Kadlecek, M. Ishii, P. Mongkolwisetwara, H. Profka, H. Hamedani, Y. XU, B. Ducka, A. Haczku, R.R. Rizi : Imaging Of Airway Remodeling In A Murine Model Of Bronchial Hyper-Responsiveness Using Hyperpolarized Gas MRI. American Journal of Respiratory and Critical Care Medicine 183: A2568, May 2011 Notes: Poster; ATS 2011 Denver, CO.

C. Koziol-White, L. Forbes, B. Ducka, K. Campbell, A. Haczku : The Role Of IL-4 In Ozone-Induced Exacerbation Of Allergic Airway Inflammation In A Murine Model American Journal of Respiratory and Critical Care Medicine 183: A2875, May 2011 Notes: Poster; ATS 2011 Denver, CO.

L.R. forbes, C. Koziol-White, Q. Wang, A. Bhandoola, B. Ducka, M. Fehrenbach, A. Haczku: Surfactant Protein D (SP-D) Inhibits Allergen-Induced Epithelial Accumulation And Promotes Lymph-Node Homing Of Myeloid Dendritic Cells. American Journal of Respiratory and Critical Care Medicine 183: A2768, May 2011 Notes: Poster; ATS 2011 Denver, CO.

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Last updated: 06/02/2014
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