Tomas S. Aleman

faculty photo
Assistant Professor of Ophthalmology at the Hospital of the University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Office: 215-662-9981
Fax: 215-662-9388
B.S. (Sciences (High Honors))
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
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Description of Research Expertise

Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials. The macular pigment is a carotenoid complex proposed to have a protective role in the human central retina. With the long-term goal of finding ways to prevent central vision loss in retinal degenerative diseases, Dr. Aleman has studied macular pigment levels and the response to supplementation with lutein in patients with inherited retinal disorders.

Clinical Trials
Dr. Aleman is an investigator in an upcoming gene therapy trial for Leber’s congenital amaurosis, the most severe form of inherited retinal degeneration.

Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, macular disorders, optical coherence tomography, electroretinogram

Description of Other Expertise

Fluent in Spanish

Description of Itmat Expertise

Hereditary retinal degenerations; macular degeneration.

Selected Publications

Elshatory YM, Carver A, Shah VA, Aleman TS: Diagnostic and Therapeutic Challenges. Retina Jul 2015 Notes: Epub ahead of print.

Brodie FL, Charlson ES, Aleman TS, Salvo RT, Lau MK, Farren ND, Engelhard SB, Pistilli M, Brucker AJ. : Obstructive sleep apnea and central serous chorioretinopathy. Retina 35(2), Feb 2015.

Aleman TS, Huang J, Garrity ST, Carter SB, Aleman WD, Ying G, Tamhankar MA.: Relationship between optic nerve appearance and retinal nerve fiber thickness as explored with spectral domain optical coherence tomography. Trans Vis Sci Tech 3(6): 4, Nov 2014.

Aleman TS, Brodie F, Garvin C, Gewaily DY, Ficicioglu CH, Mills MD, Forbes BJ, Maguire AM, Davidson SL: Retinal structure in cobalamin C disease: mechanistic and therapeutic implications. Ophthalmic Genetics Feb 2014 Notes: E Pub ahead of print.

Aleman TS, Garrity ST, Brucker AJ.: Retinal structure in vitamin A deficiency as explored with multimodal imaging. Doc. Ophthalmol. 127(3): 239-43, Dec 2013.

Moran AM, Aleman TS, Gausas RE, Fogt F. : Traumatic arteriovenous fistula of the superficial temporal artery: a histopathologic report Ophthal Plast Reconstr Surg. 29(5): 126-8, Sep-Oct 2013.

Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW. : Gene therapy for Leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 130(1): 9-24, Jan 2012

Aleman TS, Tapino PJ, Brucker AJ : Evidence of Recurrent microvascular occlusions associated with acute branch retinal artery occlusion demonstrated with SD-OCT. Retina 32 (8): 1687-1688, Sep 2012.

Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG. : Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept Hum Gene Ther 23 (4): 367-376, Apr 2012.

Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Aleman TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD : Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A. 109 (6): 2132-2137, Feb 2012.

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Last updated: 10/15/2015
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