Felix Werner Wehrli

faculty photo
Professor of Radiologic Science in Radiology
Member, Committee for Appointments and Promotions, Department of Radiology, University of Pennsylvania Medical Center
Director, Laboratory for Structural, Physiologic and Function Imaging, University of Pennsylvania Medical Center
Director, Imaging Core, Penn Center for Musculosketal Disorders, University of Pennsylvania Medical Center
Department: Radiology

Contact information
University of Pennsylvania
Department of Radiology
1 Founders Pavilion
MRI Education Center
3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7951
Fax: (215) 662-7263
Lab: (215) 349-8519
Graduate Group Affiliations
M.S. (Chemistry)
Swiss Federal Institute of Technology , 1967.
Ph.D. (Chemistry)
Swiss Federal Institute of Technology, 1970.
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Description of Research Expertise

Research of the Laboratory for Structural, Physiologic and Functional Imaging is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans.

A major focus of the Laboratory is the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy" and image-based computational biomechanics. A related area of concentration is the reduction to practice and translation to the clinic of novel quantitative solid-state proton and phosphorus MRI techniques for the study of bone matrix and mineral properties. A further line of work focuses on the quantification of systemic vascular disease via functional MRI-based methods including time-resolved blood flow, vascular compliance and venous blood oximetry with applications to the peripheral and central vascular system

Other areas of active in-house and collaborative research comprise the further development of novel non-Cartesian imaging techniques for cancer staging in the abdomen and chest, research aimed at the study of gene expression in mouse models of disease using novel micro-CT approaches, the study of neuronal architecture in mouse models of spinal cord injury by means of diffusion diffraction NMR, the development of MRI techniques to map internal strains of the intervertebral disc, and the development of novel RF coil hardware for ultra-high field MRI. Investigators in the lab have also recently embarked on a program aimed to develop and implement methods for imaging with real-time feedback control applied to fMRI of drug addiction and treatment.

Description of Itmat Expertise

Structural and functional imaging of the musculoskeletal and vascular systems with particular focus on degenerative bone diseases and atherosclerosis. Translation of laboratory imaging procedures to the clinic.

Selected Publications

Englund EK, Rodgers ZB, Langham MC, Mohler ER 3rd, Floyd TF, Wehrli FW.: Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption. Magnetic Resonance in Medicine Epub ahead of print, May 2017.

Wehrli FW, Fan AP, Rodgers ZB, Englund EK, Langham MC.: Susceptibility-based time-resolved whole-organ and regional tissue oximetry. NMR in Biomedicine 30(4), Apr 2017.

Li C, Magland JF, Zhao X, Seifert AC, Wehrli FW.: Selective in vivo bone imaging with long-T(2) suppressed PETRA MRI. Magnetic Resonance in Medicine 77(3): 989-997, Mar 2017.

Cao W, Chang YV, Englund EK, Song HK, Barhoum S, Rodgers ZB, Langham MC, Wehrli FW. : High-speed whole-brain oximetry by golden-angle radial MRI. Magnetic Resonance in Medicine Epub ahead of print, Mar 2017.

Zhao X, Song HK, Seifert AC, Li C, Wehrli FW.: Feasibility of assessing bone matrix and mineral properties in vivo by combined solid-state 1H and 31P MRI. PLOS ONE Page: e0173995, Mar 2017.

Fernández-Seara María A, Rodgers Zachary B, Englund Erin K, Wehrli Felix W: Calibrated bold fMRI with an optimized ASL-BOLD dual-acquisition sequence. NeuroImage 142: 474-482, Nov 2016.

Englund Erin K, Rodgers Zachary B, Langham Michael C, Mohler Emile R, Floyd Thomas F, Wehrli Felix W: Measurement of skeletal muscle perfusion dynamics with pseudo-continuous arterial spin labeling (pCASL): Assessment of relative labeling efficiency at rest and during hyperemia, and comparison to pulsed arterial spin labeling (PASL). Journal of Magnetic Resonance Imaging 44(4): 929-39, Oct 2016.

Chen Cheng, Jin Dakai, Liu Yinxiao, Wehrli Felix W, Chang Gregory, Snyder Peter J, Regatte Ravinder R, Saha Punam K: Trabecular bone characterization on the continuum of plates and rods using in vivo MR imaging and volumetric topological analysis. Physics in Medicine and Biology 61(18): N478-N496, Sep 2016.

Li Cheng, Seifert Alan C, Rad Hamidreza Saligheh, Bhagat Yusuf A, Rajapakse Chamith S, Sun Wenli, Benny Lam Shing Chun, Wehrli Felix W: Cortical bone water concentration: Dependence of MR imaging measures on age and pore volume fraction. Radiology 280(2): 653, Aug 2016.

Rodgers Zachary B, Detre John A, Wehrli Felix W: MRI-based methods for quantification of the cerebral metabolic rate of oxygen. Journal of Cerebral Blood Flow and Metabolism 36(7): 1165-85, Jul 2016.

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Last updated: 05/15/2017
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