Felix Werner Wehrli

faculty photo
Professor of Radiology
Member, Committee for Appointments and Promotions, Department of Radiology, University of Pennsylvania Medical Center
Director, Laboratory for Structural, Physiologic and Function Imaging, University of Pennsylvania Medical Center
Director, Imaging Core, Penn Center for Musculosketal Disorders, University of Pennsylvania Medical Center
Department: Radiology

Contact information
University of Pennsylvania
Department of Radiology
1 Founders Pavilion
MRI Education Center
3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7951
Fax: (215) 662-7263
Lab: (215) 349-8519
Graduate Group Affiliations
M.S. (Chemistry)
Swiss Federal Institute of Technology , 1967.
Ph.D. (Chemistry)
Swiss Federal Institute of Technology, 1970.
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Description of Research Expertise

Research of the Laboratory for Structural, Physiologic and Functional Imaging is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans.

A major focus of the Laboratory is the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy" and image-based computational biomechanics. A related area of concentration is the reduction to practice and translation to the clinic of novel quantitative solid-state proton and phosphorus MRI techniques for the study of bone matrix and mineral properties. A further line of work focuses on the quantification of systemic vascular disease via functional MRI-based methods including time-resolved blood flow, vascular compliance and venous blood oximetry with applications to the peripheral and central vascular system

Other areas of active in-house and collaborative research comprise the further development of novel non-Cartesian imaging techniques for cancer staging in the abdomen and chest, research aimed at the study of gene expression in mouse models of disease using novel micro-CT approaches, the study of neuronal architecture in mouse models of spinal cord injury by means of diffusion diffraction NMR, the development of MRI techniques to map internal strains of the intervertebral disc, and the development of novel RF coil hardware for ultra-high field MRI. Investigators in the lab have also recently embarked on a program aimed to develop and implement methods for imaging with real-time feedback control applied to fMRI of drug addiction and treatment.

Description of Itmat Expertise

Structural and functional imaging of the musculoskeletal and vascular systems with particular focus on degenerative bone diseases and atherosclerosis. Translation of laboratory imaging procedures to the clinic.

Selected Publications

Rajapakse Chamith S, Bashoor-Zadeh Mahdieh, Li Cheng, Sun Wenli, Wright Alexander C, Wehrli Felix W: Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology 276(2): 526-35, Aug 2015.

Seifert Alan C, Wehrli Suzanne L, Wehrli Felix W: Bi-component T2 * analysis of bound and pore bone water fractions fails at high field strengths. NMR in Biomedicine 28(7): 861-72, Jul 2015.

Seifert Alan C, Li Cheng, Wehrli Suzanne L, Wehrli Felix W: A surrogate measure of cortical bone matrix Density by long T2-suppressed MRI. Journal of Bone and Mineral Research Jun 2015.

Barhoum, S., Rodgers, Z.B., Langham, M., Magland, J.F., Li, C., Wehrli, F.W.: Comparison of MRI methods for measuring whole-brain venous oxygen saturation. Magnetic Resonance in Medicine 73(6): 2122-8, Jun 2015.

Barhoum Suliman, Langham Michael C, Magland Jeremy F, Rodgers Zachary B, Li Cheng, Rajapakse Chamith S, Wehrli Felix W: Method for rapid MRI quantification of global cerebral metabolic rate of oxygen. Journal of Cerebral Blood Flow and Metabolism May 2015.

Englund Erin K, Langham Michael C, Ratcliffe Sarah J, Fanning Molly J, Wehrli Felix W, Mohler Emile R, Floyd Thomas F: Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturation. Circulation: Cardiovascular Imaging 8(4), Apr 2015.

Zhang Ning, Magland Jeremy F, Song Hee Kwon, Wehrli Felix W: Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI. Journal of Magnetic Resonance Imaging 41(4): 954-63, Apr 2015.

Magland Jeremy F, Li Cheng, Langham Michael C, Wehrli Felix W: Pulse sequence programming in a dynamic visual environment: SequenceTree. Magnetic Resonance in Medicine Mar 2015.

Langham Michael C, Zhou Yongxia, Chirico Erica N, Magland Jeremy F, Sehgal Chandra M, Englund Erin K, Mohler Emile R, Guo Wensheng, Barhoum Suliman, Wehrli Felix W: Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature. Journal of Cardiovascular Magnetic Resonance 17: 19, Feb 2015.

Rodgers Zachary B, Englund Erin K, Langham Michael C, Magland Jeremy F, Wehrli Felix W: Rapid T2- and susceptometry-based CMRO2 quantification with interleaved TRUST (iTRUST). NeuroImage 106: 441-50, Feb 2015.

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Last updated: 10/01/2015
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