Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
Post-Graduate Training
Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973.
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975.
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv May 2023.

Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia. Blood 141: 1659-1665, Apr 2023.

Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. J Thromb Haemost 2023.

Stepanov V, Zaitsev S, McGuckin J, Saiyed A, Lin D, Jiang L, Teos L, Goncharov D, Kudryashova T, Kowalska MA, Ahn H, Poncz M, Cines DB, Goncharova E.: Intrinsic deficiency of PAI-1 drives uPA-dependent cell proliferation in human pulmonary arterial smooth muscle cells (PASMCs) from pulmonary artery hypertension (PAH) patients and induces spontaneous pulmonary hypertension (PH) in mice. American Thoracic Society 2023.

Sarkar A. Ngo AT, Khandelwat S, Gollomp K, Arepally G, Cines DB, Rauova L, Poncz M: Fc modified KKO blocks thrombosis in heparin-induced thrombocytopenia (HIT), but not in vaccine-induced thrombocytopenia and thrombosis (VITT). ISTH 2023.

Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M: ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH 2023.

Myoung SS, Khandelwal S, Francis SJ, Poncz M, Cines, DF and Arepallu GM: Value of complement activating properties of heparin induced thrombocytopenia (HIT) antibodies as surrogate marker for a functional assay. ISTH 2023.

Le HT, Golla K, Karimi R, Hughes MR, Lakschevitz F, Cines DB, Kowalska MA, Poncz M, McNagny KM, Häkkinen L, Kim H.: Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts. Sci Rep 12: 18636, Nov 2022.

Canas JJ, Liang D, Saxena V, Hooks J, Arregui SW, Gao H, Liu Y, Kish D, Linn SC, Bdeir K, Cines DB, Fairchild RL, Spencer JD, Schwaderer AL, Hains DS.: Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic Escherichia coli challenge. Proc Natl Acad Sci U S A 119: e2206515119, Oct 2022.

Rauova L, Cines DB.: Platelets get particular. Blood 140: 413-414, Aug 2022.

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Last updated: 06/02/2023
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