Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, Dept. of Pathology and Laboratory Medicine, University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Pishko Allyson M, Misgav Mudi, Cuker Adam, Cines Douglas B, George James N, Vesely Sara K, Terrell Deirdra R: Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists. Journal of thrombosis and thrombolysis 46(1): 24-30, Jul 2018.

Dai Jing, Madeeva Daria, Hayes Vincent, Ahn Hyun Sook, Tutwiler Valerie, Arepally Gowthami M, Cines Douglas B, Poncz Mortimer, Rauova Lubica: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood Jun 2018.

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK. Translational stroke research Feb 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2(3): 165-176, Feb 2018.

Raouva, L., Arepally, G., Poncz, M. and Cines, D.B: Pathogenesis of heparin-induced thrombocytopenia. Autoimmunity Reviews 2018 Notes: In press.

Florova, G., Azghani, A., Karandashova, S., Schaefer, C., Yarovoi S.V., Declerck, P.J., Cines, D.B., Idell, S. and Komissarov, A.A. : Targeting Plasminogen Activator Inhibitor 1 in Tetracycline-Induced Pleural Injury in Rabbits. Am J Physiol Lung Cell Molec Physiol 314(1): L54-L68, 2018.

108. Cuker, C., Marturano, J.E., Carinato, M., Lowery, T.J. and Cines, D.B.: T2 magnetic resonance to monitor hemostasis. Seminars in Haemostasis and Thrombosis 2018 Notes: In press.

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R. : ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Advances 1(18): 1452-65, July 2017.

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L.: Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT). ISTH. Berlin, Germany June 2017.

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M.: Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia? ISTH. Berlin, Germany June 2017.

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Last updated: 08/08/2018
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