Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, University of Pennsylvania, Perlman School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Ostertag, E.M., Bdeir K., Kacir S., Thiboutot, M., Gulendran, G., Yunk, L., Hayes, V.M., Poncz, M., Zheng, X.L., Cines, D.B. and Siegel, D.L. : ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56(7): 1775-85, Jul 2016.

Cai Z, Zhu Z, Greene MI, Cines DB. : Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). Autoimmun. 15(7): 752-5, Jul 2016.

Stepanova, V., Jayaraman, P.S., Zaitsev, S.V., Lebeda, T., Bdeir, Kh., Kershaw, R., Holman, K., Parfyonova, Y.V., Semina, E., Beloglazova, I., Boldyreva, M. Tkachuk, V.S. and Cines, D.B. : Urokinase-type plasminogen activator (uPA) promotes angiogenesis by attenuating proline-rich homeobox (PRH) transcription factor activity and de-repressing vascular endothelial cell growth factor (VEGF) receptor expression. J. Biol. Chem. 291(29): 15029-45, Jul 2016.

Ostertag, E.M., Kacir, S., Thiboutot, M.C, Gueldran, G., Zheng, X. L., Cines, D.B. and Siegel, D.L. : ADAMTS13 Autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. Transfusion 56(7): 1763-74, Jul 2016.

Parker, Z.F., Rux, A.H., Riblett, A.M., Lee, F.-H., Rauova, L., Cines, D.B., Poncz, M., Sachais, B.S., and Doms, R.W. : Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS Research and Human Retroviruses. 32(7): 705-17, Jul 2016.

Cuker, A., Cines, D.B. and Neunert, C.E. : Controversies in the treatment of immune thrombocytopenia. Current Opinion in Hematology Jul 2016.

Pillai, V.G., Bao, J., Zander, C.B., McDaniel, J.K., Cao, W., Chetty, P.S., Seeholzer, S.G. Bdeir, Kh., Cines, D.B. and Zheng, X.L. : Human neutrophil peptides (HNPs) inhibit proteolytic cleavage of von Willebrand factor by ADAMTS13: a potential trigger for thrombotic thrombocytopenic purpura. Blood 128(1): 110-9, Jul 2016.

Abu-Fanne, R., Adb-Elrahman, I., Hankin, A., Blum, G., Basheer, M., Hojazi, N., Cines, D.B., Maraga, E., and Higazi, A.A.-R: alpha-defensin promotes vascular deposition of LDL. J. Biol. Chem. 291(6): 2777-86, Feb 2016.

Fuentes, R.E., Zaitsev, S., Ahn, H.-S., Hayes, V. H., Kowalska, M.A., Lambert, M.E., Wang, Y., Siegel, D. L., Bougie, D.W., Aster, R.H., Myers, D.D., Stepanova, V., Cines, D.B., Muzykantov, V.R. and Poncz, M.: A platelet-targeted urokinase prodrug as a novel thromboprophylactic agent. J. Clin. Invest 126(2): 483-494, Feb 2016.

Tutwiler, V., Litvinov, R.I., Lozhkin, A. P., Pershova, A.D., Lebedeva, T., Ataullakhanov, F.I., Spiller, K.L., Cines, D.B, and Weisel, J.W. : Kinetics and mechanics of clot contraction are governed by molecular and cellular blood composition. Blood 127(1): 149-59, Jan 2016.

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Last updated: 07/28/2016
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