Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Director, Faculty Development, University of Pennsylvania, Perlman School of Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
Permanent link

Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Itmat Expertise

Dr. Cines works on the delivery of plasminogen activators, among other therapeutics, for the prevention and treatment of thrombotic disorders.

Selected Publications

Armstead, W.M., Riley, J, Cines, D.B. and Higazi, A.A.-R. : PAI-1 derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin and thromboxane induced cerebrovasoconstriction. Neuro. Critical Care 20(1): 111-8, Feb 2014.

Asuthkar, S., Stepanova, V., Holterman, A.-l., Estes, N., Cines, D.B. and Gondi, C.S. : Multifunctional roles of Urokinase Plasminogen Activator (uPA) in Cancer Stemness and in Chemo-resistance of Pancreatic Cancer. Molec. Biol. Cell July 2013.

Greineder, C., Howard, M.D., Carnemolla, R., Cines, D.B. and Muzykantov, V. : Advanced drug delivery systems for anti-thrombotic agents. Blood June 2013.

Larusch GA, Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin RG, Cines DB, and Schmaier AH.: uPAR's Domain 2 Regulates Single Chain Urokinase-Mediated Angiogenesis Through β1Integrin and VEGFR2. Am J Physiol Heart Circ Physiol May 2013.

Rodeghiero F, Michel M, Gernsheimer T, Ruggeri M, Blanchette V, Bussel JB, Cines DB, Cooper N, Godeau B, Greinacher A, Imbach P, Khellaf M, Klaassen RJ, Kühne T, Liebman H, Mazzucconi MG, Newland A, Pabinger I, Tosetto A, Stasi R.: Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group. Blood 121(14): 2596-606, April 2013.

Cuker, A., and Cines, D.B.: Inside Blood. Protamine induced thrombocytopenia? Blood 121: 2819, 2013.

Rauova, L. Arepally, G., Cines, D.B. and Poncz, M.: Cellular and molecular immunopathogenesis of heparin-induced thrombocytopenia. Heparin-Induced Thrombocytopenia, 5th Edition. T. Warkentin, and A. Greinacher (eds.). CRC Press, Boca Raton, FL. Page: 230-51, 2013.

Cines D.B., Lebeveda, T., Nagaswami, C., Hayes, V., Massefski, W., Lowery, T.J., and Weisel, J.W. : Contraction of whole blood clots: platelets and fibrin on the exterior compress erythrocytes into close-packed polyhedra on the interior. Int. Soc. Hematol. Thromb 2013.

Armstead WM Ph D, Bohman LE, Riley J, Yarovoi SV, Higazi AA, and Cines DB.: tPA-S481A Prevents Impairment of Cerebrovascular Autoregulation By Endogenous tPA After Traumatic Brain Injury By Upregulating p38 MAPK And Inhibiting ET-1. J Neurotrauma. 30: 1898-907, 2013.

Livintov, R.I, Sachais, B.W., Yarovoi S.V., Rauova, L., Rux, A.H., Arepally. G.M. Poncz, M., Cines, D.B., and Weisel, J.W.: Bimolecular interactions of platelet factor 4 (PF4) with HIT-pathogenic versus non-pathogenic anti-PF4 antibodies. Int. Soc. Hematol. Thromb. 2013.

back to top
Last updated: 04/15/2014
The Trustees of the University of Pennsylvania