Timothy C. Zhu

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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Associate Director, Photodynamic Therapy Physics Research, University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
University of Pennsylvania
3400 Civic Center Blvd, TRC W 4th floor
Philadelphia, PA 19104
Office: 215-662-4043
Fax: 215-615-5600
BS (Electric Engineering)
Fudan University, Shanghai, China , 1984.
M.Sc. (Physics)
Brown University , 1987.
M.Sc. (Engineering)
Brown University , 1988.
Ph.D. (Physics)
Brown University, 1991.
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Description of Research Expertise

My research focuses on PDT physics and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.

Description of Itmat Expertise

Dr. Zhu is interested in the development of an integrated system for image-guided radiation therapy and photodynamic therapy (PDT).

Selected Publications

Rozhin Penjweini, Michele M Kim, Timothy C. Zhu (senior author): Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy. Med Phys 44: published on line 4/20/2017, April 2017 Notes: DOI:10.1002/mp.12284.

Michele M. Kim, Ashwini A. Ghogare, Alexander Greer, and Timothy C. Zhu (senior author): On the in-vivo photochemical rate parameters for PDT reactive oxygen species modeling. Phys Med Biol 62(5): R1-R48, March 2017 Notes: DOI:10.1088/1361-6560/62/5/R1.

Indra J Das, Aaron Andersen, Zhe (Jay) Chen, Andrea Dimofte, Eli Glatstein, Jeremy Hoisak, Long Huang, Mark P. Langer, Choonik Lee, Matthew Pacella, Richard A. Popple, Roger Rice, Jennifer Smilowitz, Patricia Sponseller, Timothy Zhu: State of Dose Prescription and Compliance to International Standard (ICRU-83) in Intensity Modulated Radiation Therapy among Academic Institutions. Practical Radiation Oncology 7: e145-e155, March 2017 Notes: DOI:10.1016/j.prro.2016.11.003.

Michele M. Kim, Rozhin Penjweini, Timothy C. Zhu (senior author): Evaluation of singlet oxygen explicit dosimetry (SOED) for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A (BPD-MA)-mediated photodynamic therapy. J Biomed. Opt. 22: 028002, Feb 2017 Notes: DOI:10.1117/1.JBO.22.2.028002.

N. R. Gemmell, A. McCarthy, M.M. Kim, I. Veilleux, T. C. Zhu, G.S. Buller, B. C. Wilson, R. H. Hadfield: A compact Fiber Optic Probe-based Singlet Oxygen Luminescence Detection System. J Biophotonics 10(2): 320-326, Feb 2017 Notes: DOI:10.1002/jbio.201600078.

Haixia Qiu, Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, Theresa M. Busch, Tianhao Wang, Wenshen Guo, Keith A. Cengel, Charles B. Simone II, Eli Glatstein, Timothy C. Zhu (senior author): A comparison of dose metrics to predict local tumor control for photofrin-mediated photodynamic therapy. Photochem. Photobiol. 82: in press, Feb 2017 Notes: DOI:10.1111/php.12719.

Michele M. Kim, Rozhin Penjweini, Nathan R. Gemmell, Israel Veilleux, Aongus McCarthy, Gerald S. Buller, Robert H. Hadfield, Brian Wilson, Timothy C. Zhu (senior author): A comparison of singlet oxygen explicit dosimetry (SOED) and singlet oxygen luminescence dosimetry (SOLD) for Photofrin-mediated photodynamic therapy. Cancers 8: 109, December 2016 Notes: DOI:10.3390/Cancers8120109.

Yihong Ong and Timothy C Zhu (senior author): An analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium. Opt. Exp. 24(23): 26261-26281, November 2016 Notes: DOI:10.1364/OE.24.026261.

Peng Wang, Jochin Cammin, Francesca Biscello, Timothy D. Solberg, James E. McDonough, Timothy C. Zhu, David Menichelli, Boon-Keng Kevin Teo: Proton Computed Tomography Using a 1D Silicon Diode Array. Med Phys 43(10): 5758-5767, October 2016 Notes: DOI:10.1118/1.4963221.

Michele M. Kim, Rozhin Penjweini, Xing Liang, Timothy C. Zhu (senior author): Explicit macroscopic singlet oxygen modeling for benzoporphyrin derivative monoacid ring A (BPD)-mediated photodynamic therapy. J Photobiol Photochem B 164: 312-322, October 2016 Notes: DOI:10.1016/j.jphotobiol.2016.09.031.

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Last updated: 04/21/2017
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