Melpo Christofidou-Solomidou

faculty photo
Research Associate Professor of Medicine
Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA
Research Associate Professor of Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine
Investigator, Center for Excellence in Environmental Toxicology (CEET), University of Pennsylvania
Investigator, Abramson Cancer Center, University of Pennsylvania
Adjunct Faculty, Institute for Environmental Medicine (IFEM), University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3615 Civic Center Boulevard
Abramson Research Center, Office Suite 1016C
Philadelphia, PA 19104-6160
Office: (215) 573-9917
Fax: (215) 573-4469
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Description of Itmat Expertise

Dr. Christofidou-Solomidou studies pulmonary inflammation, cell adhesion molecule regulation/ expression and acute/chronic lung injury.

Selected Publications

Chowdhury Ibrul, Fisher Aron B, Christofidou-Solomidou Melpo, Gao Ling, Tao Jain-Qin, Sorokina Elena M, Lien Yu-Chin, Bates Sandra R, Feinstein Sheldon I: Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxidants & redox signaling 20(3): 391-402, Jan 2014.

Akay Cagla, Cooper Michael, Odeleye Akinleye, Jensen Brigid K, White Michael G, Vassoler Fair, Gannon Patrick J, Mankowski Joseph, Dorsey Jamie L, Buch Alison M, Cross Stephanie A, Cook Denise R, Peña Michelle-Marie, Andersen Emily S, Christofidou-Solomidou Melpo, Lindl Kathryn A, Zink M Christine, Clements Janice, Pierce R Christopher, Kolson Dennis L, Jordan-Sciutto Kelly L: Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. Journal of neurovirology Jan 2014.

Pietrofesa, RA, Solomides, CC and Christofidou-Solomidou, M: Flaxseed mitigates acute oxidative lung damage in a mouse model of repeated radiation and hyperoxia exposure associated with space exploration. Journal of Pulmonary & Respiratory Medicine 2014.

Mishra Om P, Simmons Nicholas, Tyagi Sonia, Pietrofesa Ralph, Shuvaev Vladimir V, Valiulin Roman A, Heretsch Philipp, Nicolaou K C, Christofidou-Solomidou Melpo: Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorganic & medicinal chemistry letters 23(19): 5325-8, Oct 2013.

Pietrofesa Ralph A, Turowski Jason B, Arguiri Evguenia, Milovanova Tatyana N, Solomides Charalambos C, Thom Stephen R, Christofidou-Solomidou Melpo: Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration. Journal of pulmonary & respiratory medicine 3(5), Sep 2013.

Tan Qiulin, Kerestes Heddy, Percy Melanie J, Pietrofesa Ralph, Chen Li, Khurana Tejvir S, Christofidou-Solomidou Melpo, Lappin Terence R J, Lee Frank S: Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. The Journal of biological chemistry 288(24): 17134-44, Jun 2013.

Pietrofesa Ralph, Turowski Jason, Tyagi Sonia, Dukes Floyd, Arguiri Evguenia, Busch Theresa M, Gallagher-Colombo Shannon M, Solomides Charalambos C, Cengel Keith A, Christofidou-Solomidou Melpo: Radiation mitigating properties of the lignan component in flaxseed. BMC cancer 13: 179, 2013.

Shuvaev Vladimir V, Han Jingyan, Tliba Samira, Arguiri Evguenia, Christofidou-Solomidou Melpo, Ramirez Servio H, Dykstra Holly, Persidsky Yuri, Atochin Dmitriy N, Huang Paul L, Muzykantov Vladimir R: Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo. PloS one 8(10): e77002, 2013.

Cerniglia George J, Karar Jayashree, Tyagi Sonia, Christofidou-Solomidou Melpo, Rengan Ramesh, Koumenis Constantinos, Maity Amit: Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Molecular pharmacology 82(6): 1230-40, Dec 2012.

Christofidou-Solomidou Melpo, Tyagi Sonia, Pietrofesa Ralph, Dukes Floyd, Arguiri Evguenia, Turowski Jason, Grieshaber Philip A, Solomides Charalambos C, Cengel Keith A: Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiation research 178(6): 568-80, Dec 2012.

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Last updated: 11/11/2014
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