Melpo Christofidou-Solomidou

faculty photo
Research Professor of Medicine
Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA
IACUC member, University of Pennsylvania
Investigator, Center for Excellence in Environmental Toxicology (CEET), University of Pennsylvania
Investigator, Abramson Cancer Center, University of Pennsylvania
Adjunct Faculty, Institute for Environmental Medicine (IFEM), University of Pennsylvania
Founder and Chair of the Scientific Advisory Board, LignaMed, LLC, an Upstart company in collaboration with the Penn Center for Innovation (PCI) of the University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Description of Itmat Expertise

Dr. Christofidou-Solomidou studies pulmonary inflammation, cell adhesion molecule regulation/ expression and acute/chronic lung injury.

Selected Publications

Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M and Willenbring JW: Siderophore-mediated iron removal from chrysotile: Implications on asbestos toxicity reduction and bioremediation. Journal of Hazardous Materials 341: 290-296, JAN 2018.

Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, and Christofidou-Solomidou M: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells. Biochim Biophys Acta IN REVIEW 2018.

Vladimir V. Shuvaev, Makan Khoshnejad, Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Caveolar Targeting and Anti-inflammatory Effect of Ferritin Nanocarriers with Spatially Controlled Configuration of Affinity Ligand and Enzymatic Cargo. Journal of Controlled Release IN REVIEW 2018.

Ralph A. Pietrofesa, Shampa Chatterjee, Sandra Pastorino, Haining Yang, Steven M. Albelda, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells. International Journal of Molecular Sciences IN REVIEW 2018.

Ralph A. Pietrofesa, Shampa Chatterjee, Anastasia Velalopoulou, Cynthia Koziol-White, Raymond Pannetieri, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) prevents proton radiation damage in human lung-an ex vivo study. International Journal of Molecular Sciences IN REVIEW 2018.

Slava Rom, Viviana Zuluaga-Ramirez, Nancy Lee Reichenbach, Michelle A Erickson, Malika Winfield, Sachin Gajghate, Christofidou-Solomidou M: Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: Implications for neuroinflammation. Journal of Neuroinflammation IN REVIEW 2018.

Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Ralph Pietrofesa, Athena Zuppa, Ganesh Moorthy, Neil Dyer, Christofidou-Solomidou M, and Katie Reindl: Flaxseed Consumption Inhibits Chemically--Induced Lung Tumorigenesis and Alters Expression of Phase II Enzyme and Inflammatory Cytokines in A/J Mice. Cancer Prevention Research OCT 2017.

Christofidou-Solomidou M, Ralph A. Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, and Robert Segal: Radiation mitigating properties of intranasally administered KL4 surfactant in a murine model of radiation –induced lung damage. Radiation Research Sept 2017.

Ralph A. Pietrofesa, Patrick Woodruff, Wei-Ting Hwang, Priyal Patel, Shampa Chatterjee, Steven M. Albelda and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammasome Activation in Murine Macrophages. Oxidative Medicine and Cellular Longevity ID 3795238, Sept 2017.

Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Christofidou-Solomidou M, and Katie M. Reindl: Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells. Nutrition and Cancer 69(4): 652-662, MAY 2017.

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Last updated: 10/31/2017
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