Edward J. (Jim) Delikatny

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Research Associate Professor of Radiology
Member, Abramson Cancer Center, University of Pennsylvania
Member, Institute for Translational Medicine & Therapeutics (ITMAT), University of Pennsylvania
Director, Optical Bioluminescence Sub-Core, Small Animal Imaging Facility, University of Pennsylvania
Member, Institute of Medicine & Engineering, University of Pennsylvania
Director, Small Animal Imaging Facility , University of Pennsylvania
Department: Radiology

Contact information
University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Fax: (215) 573-2113
Graduate Group Affiliations
Education:
B.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of lipid metabolic changes in response to anticancer drugs and differentiation therapy using magnetic resonance spectroscopy and MRI and optical imaging. Changes in lipid metabolites are monitored using 1H, 13C and 31P MR spectroscopy in perfused cell systems and in in vivo tumor models to determine potential biochemical markers for the detection of tumors and their early response to therapy. Changes in metabolite levels are correlated with information obtained from near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ.

A number of molecular imaging projects are active in the laboratory including the design, characterization and implementation of optical contrast agents for the detection of phospholipase, choline kinase and matrix metalloproteinase activity, and development of MR methods and contrast agents for detection of apoptosis and noninvasive detection of fatty liver and early stages of liver disease.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, anticancer drugs, lipid metabolism, cancer pharmacology

Description of Itmat Expertise

Dr. Delikatny's work focuses on non invasive detection of lipid metabolic changes in during progression of disease and in response to therapy using magnetic resonance and optical imaging.

Selected Publications

Jeitner, T.M., Kalogiannis, M., Patrick, P.A., Gomolin, I., Palaia, T., Ragolia, L., Brand, D. and Delikatny, E.J.: Inflaming the diseased brain: A role for tainted melanins. Biochimica Biophysica Acta Molecular Basis of Disease 1852(5): 937-950, May 2015.

Kumar, M., Arlauckas, S.P., Saksena, S., Verma, G., Ittyerah, R., Pickup, S., Popov, A.V., Delikatny, E.J. and Poptani, H.: Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors. Molecular Cancer Therapeutics 14(4): 899-908, Apr 2015.

Czupryna, J., Kachur, A.V., Blankemeyer, E., Popov A.V., Arroyo, A.D., Karp, J.S. and Delikatny, E.J.: Cerenkov-specific contrast agents for detection of pH in vivo. Journal of Nuclear Medicine 56(3): 483-488, Mar 2015.

Gao, Q., Yan, L., Chiorazzo, M., Delikatny, E.J., Tsourkas, A. and Cheng, Z.: PLA2-responsive and SPIO-loaded phospholipid micelles. Chemical Communications in press 2015.

Verma, G., Hariharan, H., Nagarajan, R., Nanga, R.P., Delikatny, E.J., Thomas, M.A. and Poptani, H.: Implementation of 2D L-COSY at 7T: An investigation of reproducibility in human brain. Journal of Magnetic Resonance Imaging 40(6): 1319-27, Dec 2014.

Anikeeva, N., Sykulev, Y., Delikatny, E.J. and Popov, A.V.: Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents. American Journal of Nuclear Medicine and Molecular Imaging 4(6): 507-524, Sept 2014.

Arlauckas, S.P., Popov, A.V. and Delikatny, E.J.: Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine. Molecular Cancer Therapeutics 13(9): 2149-58, Sept 2014.

Brennick, M.J., Delikatny, E.J., Pack, A.I., Pickup, S, Shinde, S., Zhu, J.-X., Roscoe, I., Kim, D.Y. Buxbaum, L.U., Cater, J.R. and Schwab, R.J.: Tongue fat infiltration in obese versus lean Zucker rats. Sleep 37(6): 1095-1102, Jun 2014.

Kachur, A.V., Popov, A.A., Delikatny, E.J., Karp, J.S. and Popov, A.V.: Synthesis of 18F-labeled phenolphthalein and naphtholphthalein. Journal of Fluorine Chemistry 151: 1-6, July 2013.

Buljan, V.A., Holsinger, R.M., Brown, D., Bohorquez-Florez, J.J., Hambly, B.D., Delikatny, E.J., Ivanova, E.P. and Banati, R.B.: Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos 23(2): 023120, Jun 2013.

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Last updated: 06/24/2015
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