Edward J. (Jim) Delikatny

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Research Associate Professor of Radiology
Member, Abramson Cancer Center, University of Pennsylvania
Member, Institute for Translational Medicine & Therapeutics (ITMAT), University of Pennsylvania
Director, Optical Bioluminescence Sub-Core, Small Animal Imaging Facility, University of Pennsylvania
Member, Institute of Medicine & Engineering, University of Pennsylvania
Director, Small Animal Imaging Facility , University of Pennsylvania
Department: Radiology

Contact information
University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Fax: (215) 573-2113
Graduate Group Affiliations
B.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, Cerenkov imaging, contrast agent design, anticancer drugs, lipid metabolism, cancer pharmacology

Description of Itmat Expertise

Dr. Delikatny's work focuses on non invasive detection of lipid metabolic changes in during progression of disease and in response to therapy using magnetic resonance and optical imaging.

Selected Publications

Judy, R.P., Keating, J.J., DeJesus, E.M., Jiang, J.X., Okusanya, O.T., Nie, S., Holt, D.E., Arlauckas, S.P., Low, P.S., Delikatny, E.J. and Singhal, S.: Quantification of tumor fluorescence during intraoperative optical cancer imaging. Scientific Reports 5: 16208, Nov 2015.

Kachur, A.V., Arroyo, A.D., Popov, A.V., Saylor, S.J. and Delikatny, E.J.: Synthesis of F-18 labeled resazurin by direct electrophilic fluorination Journal of Fluorine Chemistry 178: 136-141, Oct 2015.

Gao, Q., Yan, L., Chiorazzo, M., Delikatny, E.J., Tsourkas, A. and Cheng, Z.: PLA2-responsive and SPIO-loaded phospholipid micelles. Chemical Communications 51(61): 12313-12315, Aug 2015.

Jeitner, T.M., Kalogiannis, M., Patrick, P.A., Gomolin, I., Palaia, T., Ragolia, L., Brand, D. and Delikatny, E.J.: Inflaming the diseased brain: A role for tainted melanins. Biochimica Biophysica Acta Molecular Basis of Disease 1852(5): 937-950, May 2015.

Kumar, M., Arlauckas, S.P., Saksena, S., Verma, G., Ittyerah, R., Pickup, S., Popov, A.V., Delikatny, E.J. and Poptani, H.: Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors. Molecular Cancer Therapeutics 14(4): 899-908, Apr 2015.

Czupryna, J., Kachur, A.V., Blankemeyer, E., Popov A.V., Arroyo, A.D., Karp, J.S. and Delikatny, E.J.: Cerenkov-specific contrast agents for detection of pH in vivo. Journal of Nuclear Medicine 56(3): 483-488, Mar 2015.

Chiorazzo, M.G., Bloch, N.B., Popov, A.V. and Delikatny, E.J. : Synthesis and Evaluation of Cytosolic Phospholipase A2 Activatable Fluorophores for Cancer Imaging. Bioconjugate Chemistry in press 2015 Notes: DOI: 10.1021/acs.bioconjchem.5b00417.

Verma, G., Hariharan, H., Nagarajan, R., Nanga, R.P., Delikatny, E.J., Thomas, M.A. and Poptani, H.: Implementation of 2D L-COSY at 7T: An investigation of reproducibility in human brain. Journal of Magnetic Resonance Imaging 40(6): 1319-27, Dec 2014.

Anikeeva, N., Sykulev, Y., Delikatny, E.J. and Popov, A.V.: Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents. American Journal of Nuclear Medicine and Molecular Imaging 4(6): 507-524, Sept 2014.

Arlauckas, S.P., Popov, A.V. and Delikatny, E.J.: Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine. Molecular Cancer Therapeutics 13(9): 2149-58, Sept 2014.

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Last updated: 11/19/2015
The Trustees of the University of Pennsylvania