Edward J. (Jim) Delikatny

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Research Associate Professor of Radiology
Member, Abramson Cancer Center University of Penn
Member, Institute for Translational Medicine & Therapeutics (ITMAT) University of Penn
Director, Optical Bioluminescence Sub-Core, Small Animal Imaging Facility, University of Pennsylvania
Member, Institute of Medicine & Engineering University of Penn
Department: Radiology

Contact information
University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Buliding
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Fax: (215) 573-2113
Graduate Group Affiliations
B.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of lipid metabolic changes in response to anticancer drugs and differentiation therapy using magnetic resonance spectroscopy and MRI and optical imaging. Changes in lipid metabolites are monitored using 1H, 13C and 31P MR spectroscopy in perfused cell systems and in in vivo tumor models to determine potential biochemical markers for the detection of tumors and their early response to therapy. Changes in metabolite levels are correlated with information obtained from near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ.

A number of molecular imaging projects are active in the laboratory including the design, characterization and implementation of optical contrast agents for the detection of phospholipase, choline kinase and matrix metalloproteinase activity, and development of MR methods and contrast agents for detection of apoptosis and noninvasive detection of fatty liver and early stages of liver disease.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, anticancer drugs, lipid metabolism, cancer pharmacology

Description of Itmat Expertise

Dr. Delikatny's work focuses on non invasive detection of lipid metabolic changes in during progression of disease and in response to therapy using magnetic resonance and optical imaging.

Selected Publications

Czupryna, J., Kachur, A.V., Blankemeyer, E., Popov A.V., Karp, J.S and Delikatny, E.J. : In vivo pH detection using switchable 18F labeled Cerenkov probes. Journal of Nuclear Medicine, in press in press 2015.

Jeitner, T.M., Kalogiannis, M., Mathew, J., Patrick, P.A., Gomolin, I., Palaia, T., Ragolia. L, and Delikatny, E.J: Inflaming the diseased brain: A role for tainted melanin. BBA Molecular Basis of Disease, in press. BBA Molecular Basis of Disease, in press. in press 2015.

Brennick, M.J., Delikatny, E.J., Pack, A.I., Pickup, S, Shinde, S., Zhu, J.-X., Roscoe, I., Kim, D.Y. Buxbaum, L.U., Cater, J.R. and Schwab, R.J.: Tongue fat infiltration in obese versus lean Zucker rats. SLEEP 37: 1095-1102, 2014.

Arlauckas, S.P., Popov, A.V. and Delikatny, E.J.: Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine. Molecular Cancer Therapeutics. Molecular Cancer Therapeutics 13: 2149-58, 2014.

Anikeeva, N., Sykulev, Y., Delikatny, E.J. and Popov, A.V. : Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents. American Journal of Nuclear Medicine and Molecular Imaging Page: 507-524, 2014.

Verma, G., Hariharan, H., Nagarajan, R., Nanga, R.P.R, Delikatny, E.J., Thomas, M.A., Poptani, H. : Implementation of 2D L-COSY at 7T: An investigation of reproducibility in human brain. J.Magn Reson Imaging 40: 1319-27, 2014.

Kachur AV, Sardelis D, Bentzlet C, Popov AV, Delikatny EJ, Karp J.: Synthesis and characterization of fluorinated derivatives of cresolsulfonphthalein. Journal of Fluorine Chemistry 145: 112-117, 2013.

Kachur AV, Sardelis D, Bentzlet C, Popov AV, Delikatny EJ, Karp J.: Direct fluorination of phenolsulfonphthalein; a method for synthesis of positron-emitting indicators for in vivo pH measurement. Cell Biochemistry and BIophysics 66: 1-5, 2013.

Buljan VA, Holsinger RM, Brown D, BOhorquez-Florez JJ, Hambly BD, Delikatny EJ, Ivanova EP Banati RB: Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. CHAOS 23:023120 23, 2013.

Lee SC, Marzec M, Liu X, Wehrli S, Kantekure K, Ragunath P, Delikatany EJ, Glickson JD, Wasik M.: Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. NMR in Biomedicine 26: 106-114, 2013.

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Last updated: 01/22/2015
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