Anil Vachani

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Associate Professor of Medicine at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Attending Physician, Philadelphia Veterans Administration Medical Center
Contributor, Ask-the-Experts Board, Oncolink, University of Pennsylvania Health System
Director of Clinical Research, Section of Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine
Director of Bronchoscopy, Philadelphia VA Medical Center
Director, Lung Nodule Program, Perelman School of Medicine, Univeristy of Pennsylvania
Associate Director, Masters in Translational Research Program, ITMAT Educational Programs
Department: Medicine

Contact information
Pulmonary, Allergy, and Critical Care Division
University of Pennsylvania School of Medicine
Suite 216, Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215.573.7931
Education:
B.A. (Economics)
University of California, Berkeley, 1992.
B.S. (Genetics)
University of California, Berkeley, 1992.
M.D. (Medicine)
University of California, San Francisco, 1996.
M.S. (Clinical Epidemiology)
University of Pennsylvania, Perelman School of Medicine, 2013.
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Description of Itmat Expertise

Dr. Vachani is interested in the molecular epidemiology of lung cancer and in discovery and validation of early detection biomarkers for thoracic malignancies. His research ranges from animal models to human translational studies and includes observational and correlative studies in early and late phase clinical trials.

Selected Publications

Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW.: Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids 116: 60-66, Dec 2016.

Thompson JC, Yee SS, Troxel AB, Savitch SL, Fan R, Balli D, Lieberman DB, Morrissette JD, Evans TL, Bauml J, Aggarwal C, Kosteva JA, Alley E, Ciunci C, Cohen RB, Bagley S, Stonehouse-Lee S, Sherry VE, Gilbert E, Langer C, Vachani A, Carpenter EL: Detection of therapeutically targetable driver and resistance mutations in lung cancer patients by next generation sequencing of cell-free circulating tumor DNA. Clinical Cancer Research 22(23): 5772-5782, Dec 2016.

Schapira MM, Aggarwal C, Akers S, Aysola J, Imbert D, Langer C, Simone CB 2nd, Strittmatter E, Vachani A, Fraenkel L.: How Patients View Lung Cancer Screening: The Role of Uncertainty in Medical Decision Making. Ann Am Thorac Soc 13(11): 1969-1976, Nov 2016.

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clin Lung Cancer Oct 2016.

Schapira MM, Aggarwal C, Akers S, Aysola J, Imbert D, Langer C, Simone CB 2nd, Strittmatter E, Vachani A, Fraenkel L: How Patients View Lung Cancer Screening: The Role of Uncertainty in Medical Decision Making. Annals of the American Thoracic Society Sep 2016.

Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, Marchand LL, Li S, McNeill LH, Ryan BM, Schwartz AG, Sison JD, Spitz MR, Tucker M, Wenzlaff AS, Wiencke JK, Wilkens L, Wrensch MR, Wu X, Zheng W, Zhou W, Christiani D, Palmer JR, Penning TM, Rieber AG, Rosenberg L, Ruiz-Narvaez EA, Su L, Vachani A, Wei Y, Whitehead AS, Chanock SJ, Harris CC: Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung cancer (Amsterdam, Netherlands) 98: 33-42, Aug 2016.

Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan D, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner L, Cengel KA, Simone CB, Culligan M, Langer C, Albelda SM: Pilot and Feasibility Trial of Immuno-Gene Therapy of Malignant Mesothelioma using Intrapleural Delivery of Adenovirus-Interferon-Alpha Combined with Chemotherapy. Clin Cancer Res March 2016.

Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A: Clinical Utility of a Bronchial Genomic Classifier in Patients with Suspected Lung Cancer. Chest Feb 2016.

Vachani A, Wong YN, Israelite J, Mitra N, Hin S, Yang L, Smith-McLallen A, Armstrong K, Groeneveld PW, Epstein AJ: Validation of Molecular Pathology Codes for the Identification of Mutational Testing in Lung and Colon Cancer. Med Care Jan 22 2016.

Veenstra CM, Vachani A, Ciunci CA, Zafar HM, Epstein AJ, Paulson EC: Trends in the Use of 18F-Fluorodeoxyglucose PET Imaging in Surveillance of Non-Small-Cell Lung and Colorectal Cancer. J Am Coll Radiol Jan 2016.

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Last updated: 12/29/2016
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