Paul H. Axelsen

faculty photo
Professor of Pharmacology
Department: Pharmacology

Contact information
Department of System Pharmacology and Translational Therapeutics
10th Floor, Stellar Chance
Philadelphia, PA 19104
Office: (215) 898-9238
B.S. (Summa cum Laude, Biochemistry)
University of Minnesota, 1978.
M.D. (Medicine)
Mayo Medical School, Rochester, MN, 1982.
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Description of Research Expertise

Protein lipid interactions, especially membrane-mediated protein folding and amyloidogenesis. Optical spectroscopy, especially infrared, fluorescence, and internal reflection spectroscopy

Description of Itmat Expertise

Dr. Axelsen is investigating the mechanisms of amyloidogenesis and aging in the human brain and in vivo correlates in human brain tissue for the processes identified in vitro.

Selected Publications

Liu L, Komatsu H, Murray IVJ, Axelsen PH: Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. J Molec Biol 377: 1236-1250, 2008.

Axelsen PH: A chaotic pore model of polypeptide antibiotic action. Biophys J 94: 1549-1550, 2008.

Komatsu H, Liu L, Murray IV, Axelsen PH: A mechanistic link between oxidative stress and membrane mediated amyloidogenesis revealed by infrared spectroscopy [Review] Biochimica et Biophysica Acta 1768: 1913-1922, 2007.

Silva RAGD, Schneeweis LA, Krishnan SC, Zhang X, Axelsen PH, Davidson WS: The structure of apolipoprotein A-II in discoidal high density lipoproteins. J Biol Chem 282: 9713-9721, 2007.

Murray IVJ, Liu L, Komatsu H, Uryu K, Xiao G, Lawson JA, Axelsen PH: Membrane mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins. J Biol Chem 282: 9335-9345, 2007.

MacDonald ML, Murray IV, Axelsen PH: Mass spectrometric analysis demonstrates that BODIPY 581/591 C11 overestimates and inhibits oxidative lipid damage Free Radical Biology & Medicine 42: 1392-1397, 2007.

Cegelski L, Steuber D, Mehta AK, Kulp DW, Axelsen PH, Schaefer J: Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling. J Molec Biol 357: 1253-1262, 2006.

Londergan CH, Wang J, Axelsen PH, Hochstrasser RM: Two-dimensional infrared spectroscopy displays signatures of structural ordering in peptide aggregates. Biophys J 90: 4672-4285, 2006.

Haque ME, Koppaka V, Axelsen PH, Lentz BR: Properties and structures of the influenza and HIV fusion peptides on lipid membranes: implications for a role in fusion. Biophys J 89: 3183-3194, 2005.

Axelsen PH: Vaccine A [Review] JAMA 293: 2664, 2005.

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Last updated: 01/13/2015
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