Renyu Liu

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Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Attending Anesthesiologist, Hospital of the University of Pennsylvania, Philadelphia, PA
Co-Director of Penn-China Anesthesia Partnership Program, University of Pennsylvania School of Medicine
Director of Preoperative Medicine, Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine
Faculty of the Institute Translational Medicine and Therapeutic, The Institute Translational Medicine and Therapeutic, University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
336 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 2156623750
Fax: 2153495078
Lab: 2156623750
Education:
M.D. (Medicine)
Xuzhou Medical College, China, 1990.
MS
Jiaotong University School of Medicine, China, 1993.
Ph.D.
Tottori University School of Medicine, Japan, 2000.
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Description of Research Expertise

My major research interests are as follows:
1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
2) Pharmacological effects of opioid receptor agonists.
3) Anesthetic interaction with proteins
4) Preoperative evaluation and outcome

Description of Other Expertise

Editor in Chief, Journal of Anesthsia and Clinical Research
Partnership with Chinese anesthesiolgists

Description of Itmat Expertise

1) Potential clinical application of salvinorin A, a kappa agonist from a natual plant, Salvia divinorum.
2) structure and function of human mu receptor

Selected Publications

Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model. Brain Research 1490: 95-100, Jan 2013.

Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3(218): doi:10.4172/2155-6148.1000218, July 2012.

Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism. FASEB Journal 26(6): 2394-23400, June 2012.

Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallographica Section D 68(5): 497-504, May 2012.

Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking. Anesth Analg 114(5): 947-955, March 2012.

Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines. J Anesthe Clinic Res 3(1): 192. doi: 10.4172/2155- 6148.1000192, Feb 2012.

Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high resolution structural analysis. PLOS ONE 7(7(2):e32070), 2012 Notes: Epub 2012 Feb 16.

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology 114(2): 374-379, Feb 2011.

Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. Anesth Analg 114(1): 122-128, 2012.

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets. Anesth Analg 114(1): 200-204, 2011.

Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel. Anesthesiology Page: A713, 2010.

Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume. Anesth Analg 116(1): 112-117, Jan 2013.

Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. PLOS ONE 7(7): e41724. Epub 2012 Jul 24, 2012.

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Last updated: 10/20/2014
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