Donald M. O'Rourke

faculty photo
Associate Professor of Neurosurgery
Faculty, Department of Neurosurgery, Penn Neurological Institute, Hospital of the University of Pennsylvania
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Translational Studies Program, University of Pennsylvania
Assistant Professor, Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine
Faculty, Department of Neurosurgery, Pennsylvania Hospital, UPHS
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tissue Bank, University of Pennsylvania
Associate Professor, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
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Description of Itmat Expertise

EGFR signaling and novel therapeutics and imaging in glioblastoma

Selected Publications

Huang Menggui, Liu Tianrun, Ma Peihong, Mitteer R Alan, Zhang Zhenting, Kim Hyun Jun, Yeo Eujin, Zhang Duo, Cai Peiqiang, Li Chunsheng, Zhang Lin, Zhao Botao, Roccograndi Laura, O'Rourke Donald M, Dahmane Nadia, Gong Yanqing, Koumenis Constantinos, Fan Yi: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of clinical investigation Apr 2016.

Akbari Hamed, Macyszyn Luke, Da Xiao, Bilello Michel, Wolf Ronald L, Martinez-Lage Maria, Biros George, Alonso-Basanta Michelle, O╩╝Rourke Donald M, Davatzikos Christos: Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery 78(4): 572-80, Apr 2016 Notes: [Epub ahead of print] doi:10.1172/JCI848876.

Macyszyn Luke, Akbari Hamed, Pisapia Jared M, Da Xiao, Attiah Mark, Pigrish Vadim, Bi Yingtao, Pal Sharmistha, Davuluri Ramana V, Roccograndi Laura, Dahmane Nadia, Martinez-Lage Maria, Biros George, Wolf Ronald L, Bilello Michel, O'Rourke Donald M, Davatzikos Christos: Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro-oncology 18(3): 417-25, Mar 2016.

Coban G, Mohan S, Kural F, Wang S, O'Rourke D M, Poptani H: Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas. AJNR. American journal of neuroradiology 36(7): 1247-52, JUL 2015.

Walsh Alice M, Kapoor Gurpreet S, Buonato Janine M, Mathew Lijoy K, Bi Yingtao, Davuluri Ramana V, Martinez-Lage Maria, Simon M Celeste, O'Rourke Donald M, Lazzara Matthew J: Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Molecular cancer research : MCR 13(8): 1227-37, May 2015.

Jabehdar Maralani Pejman, Melhem Elias R, Wang Sumei, Herskovits Edward H, Voluck Matthew R, Kim Sang Joon, Learned Kim O, O'Rourke Donald M, Mohan Suyash: Association of dynamic susceptibility contrast enhanced MR Perfusion parameters with prognosis in elderly patients with glioblastomas. European radiology 25(9): 2738-44, Feb 2015.

Chowdhury Imran H, Ojerholm Eric, McMillan Matthew T, Miller Denise, Kolker James D, Kurtz Goldie, Dorsey Jay F, Nagda Suneel N, Geiger Geoffrey A, Brem Steven, O'Rourke Donald M, Zager Eric L, Gangadhar Tara, Schuchter Lynn, Lee John Y K, Alonso-Basanta Michelle: Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases. Radiation oncology (London, England) 10: 248, 2015.

Abdullah Kalil G, Ramayya Ashwin, Thawani Jayesh P, Macyszyn Lukasz, Martinez-Lage Maria, O'Rourke Donald M, Brem Steven: Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PloS one 10(5): e0127202, 2015.

Vogel Jennifer, Ojerholm Eric, Hollander Andrew, Briola Cynthia, Mooij Rob, Bieda Michael, Kolker James, Nagda Suneel, Geiger Geoffrey, Dorsey Jay, Lustig Robert, O'Rourke Donald M, Brem Steven, Lee John, Alonso-Basanta Michelle: Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases. Radiation oncology (London, England) 10: 221, 2015.

Ojerholm Eric, Lee John Y K, Thawani Jayesh P, Miller Denise, O'Rourke Donald M, Dorsey Jay F, Geiger Geoffrey A, Nagda Suneel, Kolker James D, Lustig Robert A, Alonso-Basanta Michelle: Stereotactic radiosurgery to the resection bed for intracranial metastases and risk of leptomeningeal carcinomatosis. Journal of neurosurgery 121 Suppl: 75-83, Dec 2014.

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Last updated: 04/28/2016
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