Donald M. O'Rourke

faculty photo
Associate Professor of Neurosurgery
Faculty, Department of Neurosurgery, Penn Neurological Institute, Hospital of the University of Pennsylvania
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Translational Studies Program, University of Pennsylvania
Faculty, Department of Neurosurgery, Pennsylvania Hospital, UPHS
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tissue Bank, University of Pennsylvania
Associate Professor, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
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Description of Itmat Expertise

EGFR signaling and novel therapeutics and imaging in glioblastoma

Selected Publications

Chawla S, Oleaga L, Wang SM, Krejza J, Wolf RL, Woo JH, O'Rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H: Role of Proton Magnetic Resonance Spectroscopy in Differentiating Oligodendrogliomas from Astrocytomas. J Neuroimaging 20(1): 3-8, Jan 2010.

Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, GarcĂ­a-Verdugo JM, Roy NS, Boockvar JA: Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J Neurooncol Page: In press, 2010.

Zhan Y, Counelis GJ, O'Rourke DM: The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Exp Cell Res 315(14): 2343-2357, Aug 2009.

Kapoor GS, Gocke TA, Chawla S, Whitmore RG, Nabavizadeh A, Krejza J, Lopinto J, Plaum J, Maloney-Wilensky E, Poptani H, Melhem ER, Judy KD, O'Rourke DM: Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status. J Neuro-oncol 92(3): 373-386, May 2009.

Magge SN, Malik SZ, Royo NC, Chen HI, Yu L, Snyder EY, O'Rourke DM, Watson DJ: Role of Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) in Migration of Neural Progenitor Cells Toward Glial Tumors. J Neurosci Res 87(7): 1547-1555, May 2009.

Gasparetto EL, Pawlak MA, Patel SH, Huse J, Woo JH, Krejza J, Rosenfeld MR, O'Rourke DM, Lustig R, Melhem ER, Wolf RL: Posttreatment Recurrence of Malignant Brain Neoplasm: Accuracy of Relative Cerebral Blood Volume Fraction in Discriminating Low from High Malignant Histologic Volume Fraction. Radiology 50(3): 887-896, Mar 2009.

Wang SM, Kim S, Chawla S, Wolf RL, Zhang WG, O'Rourke DM, Judy KD, Melhem ER, Poptani H: Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging. Neuroimage 44(3): 653-660, Feb 2009.

Yamoutpour F, Bodernpudi V, Park SE, Pan WH, Mauzy MJ, Kratzke RA, Dudek A, Potter DA, Woo RA, O'Rourke DM, Tindall DJ, Farassati F: Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity. Mol Cancer Ther 7(11): 3586-3597, Nov 2008.

Chawla S, Wang S, Wolf RL, Woo JH, Wang J, O'Rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H: Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas. Am J Neuroradiol 28(9): 1683-1689, Oct 2007.

Whitmore RG, Krejza J, Kapoor GS, Huse J, Woo JH, Bloom S, Lopinto J, Wolf RL, Judy K, Rosenfeld MR, Biegel JA, Melhem ER, O'Rourke DM: Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging. J Neurosurg 107(3): 600-609, Sep 2007.

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Last updated: 09/19/2012
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