Donald M. O'Rourke

faculty photo
Associate Professor of Neurosurgery
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Translational Studies Program, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tissue Bank, University of Pennsylvania
Associate Professor, Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine
Associate Professor, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Affiliate Member, The Wistar Institute Cancer Center, University of Pennsylvania, University of Pennsylvania
Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania
Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
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Description of Itmat Expertise

EGFR signaling and novel therapeutics and imaging in glioblastoma

Selected Publications

Weller M, Butowski N, Tran DD, Recht L, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust S, Iwamoto F, Drappatz J, O’Rourke DM, et al.: Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): results of a randomized, double-blind, international phase 3 trial. Lancet Oncol. August 2017 Notes: Epub ahead of print.

Roccograndi L, Binder ZA, Zhang L, Aceta N, Zhang Z, Bentores-Alj M, Nakano, I, Dahmane N, O’Rourke DM. : Shp2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol August 2017 Notes: Epub ahead of print.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. PubMed 9(399), July 2017.

Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C. : In vivo detection of EGFRvIII in glioblastoma via perfusion magnetic resonance imaging signature consistent with deep peritumoral infiltration: the φ index. Clin Cancer Res. April 2017 Notes: Epub ahead of print.

Bloch O, Lim M, Sughrue ME, Komotar RJ, Abrahams JM, O’Rourke DM, D’Ambrosio A, Bruce JN, Parsa AT.: Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L-1 Expression on Response to Therapy. Clin Cancer Res. [EPub ahead of Print] DOI:10.1158/1078-0432.CCR-16-1369, Feb 2017.

Spaethling JM, Na Y-J, Lee J, Ulyanova AV, Baltuch GH, Bell TJ, Brem S, Chen HI, Dueck H, Fisher SA, Garcia MP, Khaladkar M, Kung DK, Lucas TH, O’Rourke DM, Stefanik D, Wang J, Wolf JA, Bartfai T, Grady MS, Sul J-Y, Kim J, Eberwine JH. : Primary cell culture of live neurosurgically resected aged adult human brajn cells and single cell transcriptomics. Cell Reports 18(3): 791-803, Jan 2017.

Sahin N, Mohan S, Maralani PJ, Duddukuri S, O'Rourke DM, Melhem ER, Wolf RL.: Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI. AJR Am J Roentgenol. 207(6): 1263-1270, Dec 2016.

Huang Menggui, Liu Tianrun, Ma Peihong, Mitteer R Alan, Zhang Zhenting, Kim Hyun Jun, Yeo Eujin, Zhang Duo, Cai Peiqiang, Li Chunsheng, Zhang Lin, Zhao Botao, Roccograndi Laura, O'Rourke Donald M, Dahmane Nadia, Gong Yanqing, Koumenis Constantinos, Fan Yi: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of clinical investigation 126(5): 1804-14, May 2016.

Akbari Hamed, Macyszyn Luke, Da Xiao, Bilello Michel, Wolf Ronald L, Martinez-Lage Maria, Biros George, Alonso-Basanta Michelle, OʼRourke Donald M, Davatzikos Christos: Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery 78(4): 572-80, Apr 2016.

Macyszyn Luke, Akbari Hamed, Pisapia Jared M, Da Xiao, Attiah Mark, Pigrish Vadim, Bi Yingtao, Pal Sharmistha, Davuluri Ramana V, Roccograndi Laura, Dahmane Nadia, Martinez-Lage Maria, Biros George, Wolf Ronald L, Bilello Michel, O'Rourke Donald M, Davatzikos Christos: Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro-oncology 18(3): 417-25, Mar 2016.

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Last updated: 11/10/2017
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