Charles E. Leonard

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Research Assistant Professor of Epidemiology in Biostatistics and Epidemiology
Senior Manager, Ambulatory Drug Use and Effects Program, Penn Medicine (Philadelphia, PA)
Adjunct Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania (Philadelphia, PA)
Investigator, Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania (Philadelphia, PA)
Faculty Member, Institute for Translational Medicine and Therapeutics (ITMAT), Perelman School of Medicine at the University of Pennsylvania (Philadelphia, PA)
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania (Philadelphia, PA)
Core Faculty, Center for Therapeutic Effectiveness Research, University of Pennsylvania (Philadelphia, PA)
Fellow, Institute on Aging, University of Pennsylvania (Philadelphia, PA)
Department: Biostatistics and Epidemiology

Contact information
Perelman School of Medicine at the University of Pennsylvania
807 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-2663
Fax: 215-573-5315
PharmD (Clinical Pharmacy)
Duquesne University, 2001.
MSCE (Clinical Epidemiology (Concentration: Pharmacoepidemiology))
University of Pennsylvania, 2011.
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Description of Itmat Expertise

Pharmacoepidemiology, Cardiovascular Epidemiology, Sudden Cardiac Death, Diabetes Mellitus, Drug Interactions

Description of Research Expertise

epidemiology, pharmacoepidemiology, comparative effectiveness research, pharmacovigilance, Medicaid, Medicare, drug-drug interactions, sudden cardiac death, ventricular arrhythmia, diabetes, hypoglycemia, ischemic stroke, propensity scores, high-dimensional propensity scores

Selected Publications

Leonard CE, Han X, Brensinger CM, Bilker WB, Cardillo S, Flory JH, Hennessy S: Comparative risk of serious hypoglycemia with oral antidiabetic monotherapy: a retrospective cohort study. Pharmacoepidemiol Drug Saf [Epub ahead of print] 2017.

Leonard CE, Hennessy S, Han X, Siscovick DS, Flory JH, Deo R: Pro- and antiarrhythmic actions of sulfonylureas: mechanistic and clinical evidence. Trends Endocrinol Metab 28(8): 561-586, Aug 2017.

Leonard CE, Brensinger CM, Nam Y, Bilker WB, Barosso GM, Mangaali MJ, Hennessy S: The quality of Medicaid and Medicare data obtained from CMS and its contractors: implications for pharmacoepidemiology. BMC Health Serv Res 17(1): 304, Apr 2017.

Leonard CE, Brensinger CM, Bilker WB, Kimmel SE, Han X, Nam Y, Gagne JJ, Mangaali MJ, Hennessy S. : Gastrointestinal bleeding and intracranial hemorrhage in concomitant users of warfarin and antihyperlipidemics. Int J Cardiol 228: 761-770, Feb 2017.

Ji X, Small DS, Leonard CE, Hennessy S: The trend-in-trend research design for causal inference. Epidemiology 28(4), Apr 2017.

Leonard CE, Han X, Bilker WB, Flory JH, Brensinger CM, Flockhart DA, Gagne JJ, Cardillo S, Hennessy S: Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics. Diabetes Res Clin Pract 115: 60-7, May 2016.

Leonard CE, Bilker WB, Brensinger CM, Han X, Flory JH, Flockhart DA, Gagne JJ, Cardillo S, Hennessy S. : Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics. Clin Pharmacol Ther 99(5): 538-47, May 2016.

Hennessy S, Leonard CE, Gagne J, Flory J, Han X, Brensinger C, Bilker W: Pharmacoepidemiologic methods for studying the health effects of drug-drug interactions. Clin Pharmacol Ther 99(1): 92-100, Jan 2016.

Leonard CE, Bilker WB, Brensinger CM, Flockhart DA, Freeman CP, Kasner SE, Kimmel SE, Hennessy S: Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors. Stroke 46(3): 722-731, Mar 2015.

Leonard CE, Razzaghi H, Freeman CP, Roy JA, Newcomb CW, Hennessy S: Empiric potassium supplementation and increased survival in users of loop diuretics. PLoS One 9(7): e102279, Jul 2014.

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Last updated: 09/27/2017
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