Kyong-Mi Chang

faculty photo
Professor of Medicine
Co-Director, Immunology Program, NIH Center for Molecular Studies in Digestive & Liver Diseases, University of Pennsylvania Perelman School of Medicine
Associate Director, Penn Center for Viral Hepatitis, Hospital of University of Pennsylvania
Associate Chief of Staff for Research, Philadelphia Corporal Michael J. Crescenz VA Medical Center (CMCVAMC)
Associate Dean for Research at the Philadelphia CMC VAMC, University of Pennsylvanina Perelman School of Medicine
Department: Medicine

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
Graduate Group Affiliations
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research and mentoring VA/Penn dual-appointed Penn faculty at the CMCVAMC.

Description of Itmat Expertise

Dr. Chang uses clinical data and patient samples to examine the role of immune response in the natural history and treatment outcome of hepatitis B and hepatitis C virus infection. She has also organized a highly translational group of investigators on Penn/VA campus to conduct genetic analysis of metabolic diseases (cardiovascular, liver) using the VA Million Veterans Program genetic database.

Selected Publications

Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ: Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48 (5): 1029-1045.e5, May 2018.

NA Terrault, AS Lok, BJ McMahon, KM Chang, JP Hwang, MM Jonas, RS Brown Jr, NH Bwozej, JB Wong: Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology April 2018.

Harris RA, Haberer JE, Musinguzi N, Chang KM, Schechter CB, Doubeni CA, Gross R: Predicting short-term interruptions of antiretroviral therapy from summary adherence data: Development and test of a probability model. PLoS One 13(3): e0194713, March 2018.

Alter, A, Block TM, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Gut H, G JT, Yoshida Y, Hu J, Kowdley KV, Li W, Liang TJ, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo JA, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F: A Research Agenda for Curing Chronic Hepatitis B Virus Infection. Hepatology 67(3): 1127-1131, March 2018.

Bengsch B, Ohtani T, Herati RS, Bovenschene N, Chang KM, Wherry EJ: Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. Journal of Immunological Methods 453: 3-10, February 2018.

Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li Jin, Peloso, Chaffin M, Small AM, Huang J, Tang H, Lynch J, Ho YL, Liu D, Emdin CA,, Li AH, Huffman J, Lee JS, Natarajan P, Chowdhury R, Saleheen D, Vujkovic M, Baras A, Pyarajan S, Di Angelantonio E, Neale BM, Naheed A, Khera AV, Danesh J, Chang KM, Abecasis G, Willer C, Dewey FE, Carey DJ, MIGen Consortium, The Geisinger-Regeneron DiscovEHR Collaboration, The VA Million Veteran Program, Concato J, Gaziano JM, O’Donnel CJ, Tsao PS, Kathiresan S, Rader DJ, Wilson PWF, Assimes TL: Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program. Nature Genetics (in press) 2018.

Block TM, Alter H, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten TF, Guo JT, Hoshida Y, Kowdley KV, Li W, Lok AS, McMahon B, Mehta A, Perrillo R, Rice CM, Rinaudo J, Schinazi RF, Shetty K.: Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop. Antiviral Research 150: 93-100, December 2017.

Gowda C, Sheikh U, Maier A, Chang KM, Kaplan DE, LoRe V, Amorosa VK: Identifying barriers and potential strategies to improve HCC surveillance for HBV-infected Veterans. Federal Practitioner 34: S20-S29, June 2017.

Ojiro K, Qu X, Cho HS, Park J, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM: Modulation of HCV-specific CD8 effector T-cell function with antiviral effect in infectious hepatitis C virus co-culture model. Journal of Virology 91(10): e02129-16, May 2017.

Klarin D, Small A, Huang J, Lynch J, Arya S, Assimes T, Natarajan P, Saleheen D, Kathiresan S, Rader DJ, Concato J, Gaziano M, Cho K, Wilson P, Chang KM, O'Donnel C, Tsao P and Damrauer SM on behalf of the VA Million Veteran Program: Genetic evidence suggests a significant overlap in the pathogenesis of peripheral artery and coronary artery disease. Society for Vascular Surgery Vascular Research Initiative Conference 2017 Notes: Oral Presentation.

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Last updated: 07/17/2018
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