Kyong-Mi Chang

faculty photo
Associate Professor of Medicine
Co-Director, Immunology Program, NIH Center for Molecular Studies in Digestive & Liver Diseases, University of Pennsylvania Perelman School of Medicine
Associate Director, Penn Center for Viral Hepatitis, Hospital of University of Pennsylvania
Associate Chief of Staff for Research, Philadelphia Corporal Michael J. Crescenz VA Medical Center (CMCVAMC)
Associate Dean for Research at the Philadelphia CMC VAMC, University of Pennsylvanina Perelman School of Medicine
Department: Medicine

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
Graduate Group Affiliations
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research and mentoring VA/Penn dual-appointed Penn faculty at the CMCVAMC.

Description of Itmat Expertise

Dr. Chang uses clinical data and patient samples to examine the role of immune response in the natural history and treatment outcome of hepatitis B and hepatitis C virus infection. She has also organized a highly translational group of investigators on Penn/VA campus to conduct genetic analysis of metabolic diseases (cardiovascular, liver) using the VA Million Veterans Program genetic database.

Selected Publications

NA Terrault, AS Lok, BJ McMahon, KM Chang, JP Hwang, MM Jonas, RS Brown Jr, NH Bwozej, JB Wong: Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology (in press) 2018.

Block TM, Alter H, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten TF, Guo JT, Hoshida Y, Kowdley KV, Li W, Lok AS, McMahon B, Mehta A, Perrillo R, Rice CM, Rinaudo J, Schinazi RF, Shetty K.: Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop. Antiviral Research 150: 93-100, December 2017.

Gowda C, Sheikh U, Maier A, Chang KM, Kaplan DE, LoRe V, Amorosa VK: Identifying barriers and potential strategies to improve HCC surveillance for HBV-infected Veterans. Federal Practitioner 2017 Notes: in press.

Alter, A, Block TM, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Gut H, G JT, Yoshida Y, Hu J, Kowdley KV, Li W, Liang TJ, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo JA, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F: A Research Agenda for Curing Chronic Hepatitis B Virus Infection. Hepatology 2017 Notes: in press.

M Serper, DE Kaplan, J Lynch, JJ Lee, S Damrauer, DR Miller, Q Shao, KM Lee, P Reaven, J Huang, P Wilson, CJ O'Donnell, DJ Rader, P Tsao, D Saleheen, KM Chang: Phenotype and genotype analysis of metabolic liver disease in half million US Veterans enrolled in the Million Veteran Program (MVP) megabiobank. American Association for the Study of Liver Disease (AASLD) 68th Annual Meeting 2017 2017 Notes: oral presentation at the parallel session Genomics and Precision Hepatology.

Ojiro K, Qu X, Cho HS, Park J, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM: Modulation of HCV-specific CD8 effector T-cell function with antiviral effect in infectious hepatitis C virus co-culture model. Journal of Virology 2017 Notes: in press.

Bengsch B, Ohtani T, Herati RS, Bovenschene N, Chang KM, Wherry EJ: Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. Journal of Immunological Methods 2017 Notes: in press.

Klarin D, Small A, Huang J, Lynch J, Arya S, Assimes T, Natarajan P, Saleheen D, Kathiresan S, Rader DJ, Concato J, Gaziano M, Cho K, Wilson P, Chang KM, O'Donnel C, Tsao P and Damrauer SM on behalf of the VA Million Veteran Program: Genetic evidence suggests a significant overlap in the pathogenesis of peripheral artery and coronary artery disease. Society for Vascular Surgery Vascular Research Initiative Conference 2017 Notes: Oral Presentation.

Chang, KM, Liu M: Chronic hepatitis B: Immune pathogenesis and emerging immunotherapeutics. Current Opinion in Pharmacology 30: 93-105, October 2016.

Wang YJ, Golson ML, Schug J. Traum D, Liu C, Vivek K, Dorrel C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.: Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism 24(4): 616-626, October 2016.

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Last updated: 01/12/2018
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