Ravinder Reddy

faculty photo
Professor of Radiology
Department: Radiology

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Graduate Group Affiliations
Education:
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, 1989.
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Description of Research Expertise

My research interests are In developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer’s Disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection and spin locking for studying molecular dynamics in biological tissues in vivo.  In particular, sodium and spin-locking MRI are targeting to map proteoglycan molecules (e.g. Aggrecan) in the connective tissues in vivo. Indirect 17O MRI is aimed at studying cerebral blood flow and cerebral oxidative metabolism and tumor perfusion and metabolism.  Spin-locking MRI is being developed to impart novel contrast in various tissue types (brain, connective tissues and tumors), macromolecular ordering in tissues, and visualize and quantify Amyloidal plaques in Alzheimer’s disease in vivo. 

Description of Itmat Expertise

Dr. Reddy's research include developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer's disease.

Selected Publications

Kogan F, Haris M, Singh A, Cai K, DeBrosse C, Nanga RPR, Hariharan H, Reddy R. : Method for High-Resolution Imaging of Creatine In vivo Using Chemical Exchange Saturation Transfer. Magn. Reson. Med. Feb 2013.

Cai K, Xu HN, Singh A, Haris M, Reddy R, Li LZ : Characterizing Prostate Tumor Mouse Xenografts with CEST and MT-MRI and Redox Scanning. Adv Exp Med Biol. 765: 39-45, 2013.

1. Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido GA, Walter RT Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Robert Gorman RC, Reddy R. : A Novel Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism. Nature Medicine 2013.

Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R : Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed 25((11)): 1305-09, Nov 2012.

Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R: MICEST: A potential tool for non-invasive detection of molecular changes in Alzheimer's disease. J Neurosci Methods 212((1)): 87-93, Oct 2012.

Singh A, Haris M, Cai K, Kassey VB, Kogan F, Reddy D, Hariharan H, Reddy R.: Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T. Magn Reson Med 68((2)): 588, Aug 2012.

Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. : Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Magn. Reson. Med. 68((1)): 107, Jul 2012.

Pilkinton DT, Hiraki T, Detre JA, Greenberg JH, Reddy R. : Absolute cerebral blood flow quantification with pulsed arterial spin labeling during hyperoxia corrected with the simultaneous measurement of the longitudinal relaxation time of arterial blood. Magn. Reson. Med. 67((6)): 1556, Jun 2012.

Cai K, Shore A, Singh A, Haris M, Hiraki T, Waghray P, Reddy D, Greenberg J H and Reddy R: Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research. NMR in Biomed Page: 2780, Feb 2012.

Cai K., Haris M., Singh A., Kogan F., Greenberg J., Hariharan H., Detre, J. A., Reddy R. : Magnetic Resonance Imaging of Glutamate. Nature Medicine 18((2)): 302, Jan 2012.

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Last updated: 08/06/2013
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