Emma Anne Meagher
Associate Professor of Medicine at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Physician, Hospital of the University of Pennsylvania, University of Pennsylvania Health System
Director, Patient Oriented Research Training Program , University of Pennsylvania School of Medicine
Associate Director, Cardiovascular Risk Intervention Program, University of Pennsylvania Health System
Executive Chair, Institutional Review Board, University of Pennsylvania School of Medicine
Director, Master of Science Degree program in Translational Research, University of Pennsylvania Perelman School of Medicine
Director, Translational Research Education, Institute of Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Associate Vice Provost for Human Research, University of Pennsylvania
Interim Associate Dean Medical School Admissions, University of Pennsylvania Perelman School of Medicine
Department: Medicine
Contact information
ITMAT
8032 Maloney Building
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283
8032 Maloney Building
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-662-2174
Fax: 215-614-0378
Fax: 215-614-0378
Email:
EMMA@UPENN.EDU
EMMA@UPENN.EDU
Education:
M.D. (Medicine)
Royal College of Surgeons in Ireland, 1987.
Permanent linkM.D. (Medicine)
Royal College of Surgeons in Ireland, 1987.
Description of Research Expertise
Dr. Meagher's research interests include mechanisms of vascular dysfunction in cardiovascular disease, alcohol induced liver disease and the role of antioxidant vitamin therapy in both primary and secondary prevention of disease. Dr. Meagher is also interested in the field of oxidant injury in atherosclerosis. Her clinical practice is in the area of cardiovascular risk modification with an emphasis on management of dyslipidemia, hypertension and women's cardiovascular health.Description of Itmat Expertise
1. Evaluation of novel therapeutic approaches in hypertension and hyperlipidemia2. Development and evaluation of educational approaches to translational reserach and preventing cardiovascular disease.
Selected Publications
Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ: A Phase 3 study of lomitapide, a microsomal triglyceride transfer protein (MTP) inhibitor, in patients with homozygous familial hypercholesterolemia. European Atherosclerosis Society. 80th Congress, 25 28 May 2012, Milan, Italy. Oral presentation. 2012.Rader DJ, Meagher EA, Cuchel M, On behalf of the Phase 3 HoFH Lomitapide Study Investigators.: A Phase 3 study of the Microsomal Triglyceride Transfer Protein (MTP) Inhibitor Lomitapide in Patients with Homozygous Familial Hypercholesterolemia. National Lipid Association 2012 Scientific Sessions. 2012.
Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ : Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 380(11), 2012.
Meagher EA, Fitzgerald GA.: Efficient drug approval and monitoring must rely on sound regulatory science. Nat Med. 17(12): 1535, Dec 2011.
Meagher EA. : Training Translators in the PENN CTSA. Clin Transl Sci. 4(5): 314-6, October 2011.
Meagher EA, Taylor L, Probsfield J, Fleming M.: Evaluating research mentors working in the area of clinical translational science: a review of the literature. Clin Transl Sci. 4(5): 353-8, October 2011.
Fisher ND, Meagher EA.: Renin Inhibitors. J Clin Hypertens 13(9): 662-6, September 2011.
Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ: Phase 3 study of microsomal triglyceride transfer protein inhibitor (MTP-1) lomitapide in subjects with homozygous familial hypercholesterolemia (HOFH): 56-week results. European Atherosclerosis Society. 78th Congress, 20-23 June 2010, Hamburg, Germany. Oral presentation. 2010.
Cuchel M, Meagher EA, Marais DJ, Theron HT, Beer AL, Sasiela WJ, Rader DJ.: A Phase III Study of Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in patients with Homozygous Familial Hypercholesterolemia: Interim Results at Six Months. American Heart Association Scientific Sessions 2009. November 2009 Notes: Circulation 120:S441, Nov 2009.
Meagher EA, Davidson M, Rosen M, Bays H, Sasiela WJ, Rader DJ. : Effects of Low Dose MTP Inhibition Alone and in Combination with Other Lipid-Lowering Drugs on Hepatic Fat and Plasma Lipids. The XV International Society of Atherosclerosis Scientific Meeting 2009. 2009.