Peter F. Davies

faculty photo
Professor of Pathology and Laboratory Medicine
Co-Director, Research Program in Biotechnology, Cardiovascular Research Institute
Member, and Advisory Board Member, Institute for Translational Medicine and Therapeutics
Co-Director, HHMI-NIBIB Graduate Program in Biomedical Imaging and Informational Sciences
Department: Pathology and Laboratory Medicine

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Graduate Group Affiliations
B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, 1969.
M.Sc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
University of Cambridge, 1975.
Sc.D. (Higher Doctorate)
University of Cambridge, 2015.
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Description of Research Expertise

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics and computational fluid dynamics. Endocardial endothelium and 4D-flow MRI.

Rotation Projects
Please discuss with Dr. Davies.

Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Margaret McCormick PhD, Postdoctoral Fellow
Yizhou Jiang PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD
Alex Sotolongo, Medical School Fellow

Description of Other Expertise

Biophysics; Lipid metabolism

Description of Itmat Expertise

Dr. Davies is interested in quantitative aspects of vascular pathophysiology especially the influence of hemodynamics.

Selected Publications

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc 18;5(4). pii: e003170.: doi: 10.1161/JAHA.115.003170, April 2016.

Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Sabin J and Jones P. Pub: Routledge / Taylor and Francis (2016). In Press. Routledge / Taylor and Francis In Press(In Press), In Press 2016.

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics In press 2016.

Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z: Perspectives. Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of Mechanotransduction in the Endothelium. Journal of Biomechanics In press 2016.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 9(7): 6785-6793, July 2015.

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.

Kwak, B., Back M., Bochaton-Piallat, M.L., Caligiuri, G., Daemen, M., Davies, P.F., Hoefer, I., Holvoet, P., Krams, R., Monaco, C., Virmani, R., Weber, C., Wentzel Y., Evans, P.: Biomechanical factors in atherosclerosis - Mechanisms and implications. European Heart Journal. European Society Cardiology, 35(43): 3013-3020, Sept 2014.

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Last updated: 07/11/2016
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