George Coukos

faculty photo
Member, , Center for Research on Women’s Health and Reproduction, University of Pennsylvania Medical Center, University of Pennsylvania
Associate Chief, Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Pennsylvania Medical Center
Administrative Director,, the University of Pennsylvania FCCC-PENN SPORE in Ovarian Cancer
Emeritus Director, Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA
Department: Obstetrics and Gynecology

Contact information
Université de Lausanne
Bureau BU27/01/124
Rue du Bugnon 27
Lausanne, CH-1011
Office: 41 (0)21 314 06 27
Lab: 41 (0)79 556 73 97
Graduate Group Affiliations
University of Modena School of Medicine, Modena, Italy (Cum Laude), 1987.
Ph.D. (Reproductive Biology)
University of Patras School of Medicine, Patras, Greece, Department of Obstetrics and Gynecology, Thesis: Placental Neuropeptides: GnRH and CRH, 1990.
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Description of Itmat Expertise

Dr. Coukos is investigating ovarian cancer, including the development of novel biological and immune therapeutics.

Selected Publications

GT Motz, LP Wang, T Garrabrant, R Lastra, IS Hagemann, P Lal, F Benencia, MD Feldman, G Coukos: Expression of FasL on the Tumor Endothelium Establishes a Selective Immune Barrier in Tumors. Nature Med 20(6):607-15, Jun 2014.

E Matthaiou J Barrar, C Li, R Sandaltzopoulos, G Coukos, Y Omidi: Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer. Intern J Nanother 15;9:1855-70, Apr 2014.

C Li, AM Chacko, J Hu, K Hasegawa, J JeSwails, L Grasso, WS El-Deiry, N Nicolaides, VR Muzykantov, CR Divgi, G Coukos: Antibody-Based Tumor Vascular Theranostics Targeting the Human Endosialin/TEM1 In Vivo. Ca Biol Ther 15(4):443-51, Apr 2014.

J Facciponte, X Ping, J Rueter, G Coukos, A Facciabene: A DNA Vaccine against the Tumor Endothelial Marker 1 Targets the Tumor Vasculature. J Clin Invest 1;124(4):1497-511, Apr 2014.

AM Chacko, C Li, M Nayak, JL Mikitsh, J Hu, J Hou, L Grasso, N Nicolaides, VR Muzykantov, CR Divgi, G Coukos: Development of Tumor Immuno-PET Imaging Targeting Vascular TEM1/Endosialin. J Nuclear Med 55(3):500-7, Mar 2014.

Q Ye, D Song, M Poussin, T Yamamoto, A Best, C Li, G Coukos, DJ Powell Jr: CD137 accurately identifies and enriches for naturally-occurring tumor-reactive T cells in tumor. Clin Cancer Res 1;20(1):44-55, Jan 2014.

J Duraiswamy, GJ Freeman, G Coukos: Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors--Response. Cancer Res 15;74(2):633-4, Jan 2014.

J Duraiswamy, GJ Freeman, G Coukos: Therapeutic PD-1 Pathway Blockade Augments with other Modalities of Immunotherapy to Prevent Immune Decline in Ovarian Cancer. Cancer Res 1;73(23):6900-12, Dec 2013.

JY Yang, K Yoshihara, K Tanaka, M Hatae, H Masuzaki, H Itamochi, M Takano, K Ushijima, JL Tanyi, G Coukos, Y Lu, GB Mills, RG Verhaak: Predicting time to ovarian carcinoma recurrence using protein markers. J Clin Invest 3;123(9):3740-50, Sep 2013.

CL Chiang, LE Kandalaft, J Tanyi, AR Hagemann, GT Motz, N Svoronos, K Montone, GM Mantia-Smaldone, L Smith, HL Nisenbaum, BL Levine, M Kalos, BJ Czerniecki, DA Torigian, DJ Powell Jr, R Mick, G Coukos: A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clin Cancer Res 1;19(17):4801-15, Sep 2013.

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Last updated: 11/03/2014
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