George Coukos
Celso-Ramon Garcia Professor of Reproductive Biology
Member, , Center for Research on Women’s Health and Reproduction, University of Pennsylvania Medical Center, University of Pennsylvania
Associate Chief, Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Pennsylvania Medical Center
Director, Ovarian Cancer Research Center University of Pennsylvania Medical Center
Administrative Director,, the University of Pennsylvania
FCCC-PENN SPORE in Ovarian Cancer
Department: Obstetrics and Gynecology
Contact information
University of Pennsylvania
Ovarian Cancer Research Center
Room 1315, Biomedical Research Building II/III
421 Curie Blvd.
Philadelphia, PA, 19104-6160
gcks@mail.med.upenn.edu
Philadelphia, PA 19104-6160
Ovarian Cancer Research Center
Room 1315, Biomedical Research Building II/III
421 Curie Blvd.
Philadelphia, PA, 19104-6160
gcks@mail.med.upenn.edu
Philadelphia, PA 19104-6160
Office: 215-573-5016
Fax: 215-573-5129
Fax: 215-573-5129
Email:
gcks@mail.med.upenn.edu
gcks@mail.med.upenn.edu
Graduate Group Affiliations
Education:
M.D.
University of Modena School of Medicine, Modena, Italy (Cum Laude), 1987.
Ph.D. (Reproductive Biology)
University of Patras School of Medicine, Patras, Greece Department of Obstetrics and Gynecology Thesis: Placental Neuropeptides: GnRH and CRH, 1990.
Permanent linkM.D.
University of Modena School of Medicine, Modena, Italy (Cum Laude), 1987.
Ph.D. (Reproductive Biology)
University of Patras School of Medicine, Patras, Greece Department of Obstetrics and Gynecology Thesis: Placental Neuropeptides: GnRH and CRH, 1990.
Description of Itmat Expertise
Dr. Coukos is investigating ovarian cancer, including the development of novel biological and immune therapeutics.Selected Publications
Zhao Aizhi, Nunez-Cruz Selene, Li Chunsheng, Coukos George, Siegel Don L, Scholler Nathalie: Rapid isolation of high-affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast-display/secretory scFv library platform. Journal of immunological methods 363(2): 221-32, Jan 2011.Tanyi Janos L, McCann Georgia, Hagemann Andrea R, Coukos George, Rubin Stephen C, Liao John B, Chu Christina S: Clinical predictors of bevacizumab-associated gastrointestinal perforation. Gynecologic oncology Dec 2010.
Zhong Xiaomin, Li Ning, Liang Shun, Huang Qihong, Coukos George, Zhang Lin: Identification of MicroRNAs Regulating Reprogramming Factor LIN28 in Embryonic Stem Cells and Cancer Cells. The Journal of biological chemistry 285(53): 41961-71, Dec 2010.
Yang Xiaojun, Lin Xiaojuan, Zhong Xiaomin, Kaur Sippy, Li Ning, Liang Shun, Lassus Heini, Wang Liping, Katsaros Dionyssios, Montone Kathleen, Zhao Xia, Zhang Youcheng, Bützow Ralf, Coukos George, Zhang Lin: Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer research 70(22): 9463-72, Nov 2010.
Kandalaft Lana E, Motz Gregory T, Busch Johanna, Coukos George: Angiogenesis and the Tumor Vasculature as Antitumor Immune Modulators: The Role of Vascular Endothelial Growth Factor and Endothelin. Current topics in microbiology and immunology Aug 2010.
Chiang Cheryl Lai-Lai, Benencia Fabian, Coukos George: Whole tumor antigen vaccines. Seminars in immunology 22(3): 132-43, Jun 2010.
Demaria Sandra, Pikarsky Eli, Karin Michael, Coussens Lisa M, Chen Yen-Ching, El-Omar Emad M, Trinchieri Giorgio, Dubinett Steven M, Mao Jenny T, Szabo Eva, Krieg Arthur, Weiner George J, Fox Bernard A, Coukos George, Wang Ena, Abraham Robert T, Carbone Michele, Lotze Michael T: Cancer and inflammation: promise for biologic therapy. Journal of immunotherapy (Hagerstown, Md. : 1997) 33(4): 335-51, May 2010.
Kandalaft Lana E, Singh Nathan, Liao John B, Facciabene Andrea, Berek Jonathan S, Powell Daniel J, Coukos George: The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade. Gynecologic oncology 116(2): 222-33, Feb 2010.
Deng Shan, Yang Xiaojun, Lassus Heini, Liang Shun, Kaur Sippy, Ye Qunrui, Li Chunsheng, Wang Li-Ping, Roby Katherine F, Orsulic Sandra, Connolly Denise C, Zhang Youcheng, Montone Kathleen, Bützow Ralf, Coukos George, Zhang Lin: Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PloS one 5(4): e10277, 2010.
Li Chunsheng, Feng Yi, Coukos George, Zhang Lin: Therapeutic microRNA strategies in human cancer. The AAPS journal 11(4): 747-57, Dec 2009.