Bonnie Ky

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Assistant Professor of Medicine
Faculty Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Attending Physician, Hospital of the University of Pennsylvania, Cardiology Consult and/or CCU service, 1-2 inpatient blocks/yr.
Director, Penn Center for Quantitative Echocardiography
Member, Abramson Cancer Center
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-573-6606
Fax: 215-746-7415
Education:
BS (Chemical Engineering )
Massachusetts Institute of Technology, 1995.
MD (Medicine)
University of Pennsylvania, 2001.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2009.
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Description of Itmat Expertise

neuregulin signaling, endothelial growth factor signaling, cancer therapy cardiotoxicity, cardiac remodeling, echocardiography

Description of Research Expertise

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.


2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.


3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications

Wells QS, Veatch OJ, Fessel JP, Joon AY, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke P, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, and Roden DM: Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenetics and Genomics 27(7): 247-254, Jul 2017.

Finkelman B, Putt M, Wang T, Wang L,Narayan H, Domchek S, DeMichele A, FOx K, Matro J, Shah P, Clark A, Bradbury A, Narayan V, Carver JR, Tang W, Ky B: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer. Journal of the American College of Cardiology 70(2): 152-162, July 2017.

Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH: Dose-Response Effects of Aerobic Exercise among Colon Cancer Survivors: A Randomized Phase II Trial. Clinical Colorectal Cancer June 17 2017 Notes: Epub ahead of print.

Narayan HK, Finkelman BS, French B, Plappert T, Hyman D, Smith AM, Margulies KB, Ky B: Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations with Ejection Fraction Decline, Recovery, and Heart Failure Symptoms over 3 Years of Followup. Circulation 135(15): 1397-1412, April 2017 Notes: Epub 2017 Jan 19.

Aimo A, Vergaro G, Passino C, Ripoli A, Ky B, Miller WL, Bayes-Genis A, Anand I, Januzzi JL, Emdin M: Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure: A Meta-Analysis. JACC Heart Failure 5(4): 280-286, April 2017 Notes: Epub 2016 Nov 2.

Narayan V, Keefe S, Haas N, Wang L, Puzanov I, Putt M, Catino A, Fang J, Agarwal N, Hyman D, Smith AM, Finkelman BS, Nayan HK, Ewer S, ElAmm C, Lenihan D, Ky B: Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma. Clinical Cancer Research Feb 14 2017 Notes: Epub ahead of print.

Kawut SM, Archer-Chicko CL, DiMichele A, Fritz JS, Klinger JR, Ky B, Palevsky HI, Palmisciano AJ, Patel M, Pinder D, Propert KJ, Smith KA, Stanczyk F, Tracy R, Vaidya A, Whittenhall ME, Ventetuolo CE: Anastrozole in Pulmonary Arterial Hypertension (AIPH): A Randomized, Double-Blind Placebo-Controlled Trial. American Journal of Respiratory and Critical Care Medicine 195(3): 360-368, Feb 2017.

O'Farrell ACO, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray D, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraster A, Liljenback H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, Mc Auliffe F, Rousseau JA, Lecomte R, Gacson S, Ky B, Force T, Arany Z, Knuuti J, Gallagher W, Roivainen A, Byrne AT: A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate. Plos One 12(1): e0169964, Jan 2017 Notes: eCollections 2017.

Narayan HK, Wei W, Feng Z, Lenihan D, Plappert T, Englefield V, Fisch M, Ky B.: Cardiac mechanics and dysfunctionwith anthracyclines in the community: results from the PREDICT study. Open Heart 4(1): e000524, Jan 2017 Notes: eCollection 2017.

Beer LA, Ky B, Barnhart KT, Speicher DW: In Depth, Reproducible Analysis of Human Plasma Using IgY 14 and SuperMix Immunodepletion. Methods Mol Biol 1619: 81-101, 2017.

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Last updated: 08/05/2017
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