Bonnie Ky

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Faculty Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Attending Physician, Hospital of the University of Pennsylvania, Cardiology Consult and/or CCU service, 1-2 inpatient blocks/yr.
Director, Penn Center for Quantitative Echocardiography
Member, Abramson Cancer Center
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-573-6606
Fax: 215-746-7415
BS (Chemical Engineering )
Massachusetts Institute of Technology, 1995.
MD (Medicine)
University of Pennsylvania, 2001.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2009.
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Description of Itmat Expertise

neuregulin signaling, endothelial growth factor signaling, cancer therapy cardiotoxicity, cardiac remodeling, echocardiography

Description of Research Expertise

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.

2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.

3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications

Tchou J, Lam L, Li YR, Edwards C, Ky B, Zhang H: Monitoring Serum HER2 Levels in Breast Cancer Patients. Spring House Breast Cancer Collection 2015 Notes: Accepted for publication May 2015.

Haas, N Manola J, Ky B, Flaherty K, Uzzo RG, Kane CJ, Jewett M, Wood CG, Atkin MB, Dutcher JJ, DiPaolo RS: Effects of Sorafenib and Sunitinib on Cardiac Function in a Population without Overt Metastases: Cardiac Sub-study of a Phase III Trial of Sunitinib or Sorafenib or Placebo in Patients with High Risk Resected Renal Cell Carcinoma (E2805). Clinical Cancer Research 2015 Notes: Accepted for publication May 2015.

Grandin E, Ky B, Cornell RF, Carver J, Lenihan DJ: Patterns of Cardiac Toxicity Associated with Irreversible Proteasome Inhibition in the Treatment of Multiple Myeloma. Journal of Cardiac Failure Page: doi: 10.1016/j.cardfail.2014.11.008, November 2014 Notes: epub ahead of print.

Vorovich E, French B, Ky B, Fang JC, Sweitzer NK, Cappola TP: Biomarker Predictors of Recurrent Cardiac Hospitalization in Chronic Heart Failure. Journal of Cardiac Failure 20(8): 569-76, August 2014.

St John Sutton M, Ky B, Regner SR, Schadt K, Plappert T, D'Souza B, Lynch DR: Longitudinal Strain in Friedreich Ataxia: A Potential Marker for Early Left Ventricular Dysfunction. Echocardiography 31(1): 50-57, August 2014 Notes: epub 2013.

Basuray A, French B, Ky B, Sweitzer NK, Vorovich E, Cappola TP, Fang JC: Heart Failure with Recovered Ejection Fraction: Clinical Description, Biomarkers, and Outcomes. Circulation 129(23): 2380-7, June 2014.

Ky B, Putt ME, Sawaya H, French B, Sebag I, Plana JC, Januzzi JL, Tan TC, Cohen V, Banchs J, Carver J, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M: Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab. Journal of the American College of Cardiology 63(8): 809-16, March 2014.

Zhang KW, French B, Khan AM, Plappert T, Fang JC, Sweitzer NK, St John Sutton M, Cappola TP, Ky B: Strain Improves Risk Prediction Beyond Ejection Fraction in Chronic Systolic Heart Failure. Journal of the American Heart Association 3(1), January 2014.

Ky B, French B, May Khan A, Plappert T, Wang A, Chirinos JA, Fang JC, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP: Ventricular-Arterial Coupling, Remodeling, and Prognosis in Chronic Heart Failure. Journal of the American College of Cardiology 62(13): 1165-72, September 2013.

Ky B, Shults J, Keane MG, St John Sutton M, Wolf M, Feldman HI, Reese P, Anderson C, Townsend R, Lo J, Gadegeku C, Carlow D, Sulik M, Leonard MB: FGF23 Modifies the Relationship Between Vitamin D and Cardiac Remodeling. Circulation Heart Failure 6(4): 817-24, July 2013.

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Last updated: 05/22/2015
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