Allan I. Pack

faculty photo
John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Chief, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Itmat Expertise

Major interest is in genomic/genetic approaches to sleep and its disorders. Studies to identify genetic risk factors for the common disorder sleep apnea and what determines the individual differences in response to sleep deprivation are in progress. These studies are being complemented by investigations to identify molecular signatures for sleep apnea and sleep deprivation. The approach being taken is to identify dynamic changes in expression of candidate genes and also expression profiling in circulating leukocytes and monocytes across the sleep period or with sleep deprivation.

Selected Publications

Pellegrino, R., Kavakli, I.H., Goel, N., Cardinale, C.J., Dinges, D.F., Kuna, S.T., Maislin, G., Van Dongen, H.P.A., Tufik, S., Hogenesch, J.B., Hakonarson, H. and Pack, A.I.: A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep 37(8): 1327-1336, Aug 2014.

Keenan, B.T., Maislin, G., Sunwoo, B.Y., Arnardottir, E.S., Jackson, N., Olafsson, I., Juliusson, S., Schwab, R.J., Gislason, T., Benedikstdottir, B. and Pack, A.I.: Obstructive sleep apnoea treatment and fasting lipids: A comparative effectiveness study. European Respiratory Journal 44(2): 405-414, Aug 2014.

Brennick, M.J., Delikatny, J., Pack, A.I., Pickup, S., Shinde, S., Zhu, J.X., Roscoe, I., Kim, D.Y., Buxbaum, L.U., Cater, J.R. and Schwab, R.J.: Tongue fat infiltration in obese versus lean Zucker rats. Sleep 37(6): 1095-1102, Jun 2014.

Brown, M.K., Chan, M.T., Zimmerman, J.E., Pack, A.I., Jackson, N.E. and Naidoo, N.: Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiology of Aging 35(6): 1431-1441, Jun 2014.

Sutherland, K., Schwab, R.J., Maislin, G., Lee, R.W.W., Benedikstdottir, B., Pack, A.I., Gislason, T., Juliusson, S. and Cistulli, P.A.: Facial phenotyping by quantitative photography reflects craniofacial morphology measured on MRI in Icelandic sleep apnea patients. Sleep 37(5): 959-968, May 2014.

Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Strachan, E. and Goldberg, J.: Sleep duration and depressive symptoms: a gene-environment interaction. Sleep 37(2): 351-358, Feb 2014.

Pien, G.W., Pack, A.I., Jackson, N., Maislin, G., Macones, G.A. and Schwab, R.J.: Risk factors for sleep-disordered breathing in pregnancy. Thorax 69(4): 371-377, 2014.

Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Podtelezhnikov, A.A., Anafi, R., Tanis, K.Q., Maislin, G., Stone, D.J., Renger, J.J., Winrow, C.J. and Pack, A.I.: Blood gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 2014 Notes: In press.

Ye, L., Pien, G.W., Ratcliffe, S.J., Bjornsdottir, E., Arnardottir, E.S., Pack, A.I., Benediktsdottir, B. and Gislason T: The difference clinical faces of obstructive sleep apnoea: a cluster analysis. European Respiratory Journal 2014 Notes: Sep 3. pii: erj00323-2014. [Epub ahead of print]

Pak, V.M., Keenan, B.T., Jackson, N., Grandner, M.A., Maislin, G., Teff, K., Schwab, R.J., Arnardottir, E.S., Juliusson, S., Benediktsdottir, B., Gislason, T. and Pack, A.I. : Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. International Journal of Obesity (London) 2014 Notes: Jul 21. doi: 10.1038/ijo.2014.123. [Epub ahead of print]

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Last updated: 09/05/2014
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