Allan I. Pack

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John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Chief, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Itmat Expertise

Major interest is in genomic/genetic approaches to sleep and its disorders. Studies to identify genetic risk factors for the common disorder sleep apnea and what determines the individual differences in response to sleep deprivation are in progress. These studies are being complemented by investigations to identify molecular signatures for sleep apnea and sleep deprivation. The approach being taken is to identify dynamic changes in expression of candidate genes and also expression profiling in circulating leukocytes and monocytes across the sleep period or with sleep deprivation.

Selected Publications

Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature. Journal of Applied Physiology (1985) 121(1): 78-88, Jul 2016.

Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring. Journal of Clinical Sleep Medicine 12(6): 855-863, Jun 2016.

Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health. Sleep 39(4): 727-736, Apr 2016.

Lyons, M.M., Bhatt, N.Y., Kneeland-Szanto, E., Keenan, B.T., Pechar, J., Stearns, B., Elkassabany, N.M., Memtsoudis, S.G., Pack, A.I. and Gurubhagavatula, I.: Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility. Biomarkers in Medicine 10(3): 265-300, 2016.

Malone, S.K., Zemel, B., Compher, C., Souders, M., Chittams, J., Thompson, A.L., Pack, A. and Lipman, T.H.: Social jet lag, chronotype and body mass index in 14-17-year-old adolescents. Chronobiology International 2016 Notes: DOI: 10.1080/07420528.2016.1196697.

Soans, R.E., Lim, D.C., Keenan, B.T., Pack, A.I. and Shackleford, J.A.: Automated protein localization of blood brain barrier vasculature in brightfield IHC images. PLoS One 11(2): e0148411, 2016.

Perron, I.J., Pack, A.I. and Veasey, S.: Diet/energy balance affect wakefulness independent of body weight. Sleep 38(12): 1893-1903, Dec 2015.

Bjornsdottir, E., Keenan, B.T., Eysteinsdottir, B., Arnardottir, E.S., Janson, C., Gislason, T., Sigurdsson, J.F., Kuna, S.T., Pack, A.I. and Benediktsdottir, B.: Quality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. Journal of Sleep Research 24(3): 328-338, Jun 2015.

Li, Q.Y., Berry, R.B., Goetting, M.G., Staley, B., Soto-Calderon, H., Tsai, S.C., Jasko, J.G., Pack, A.I. and Kuna, S.T.: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, Apr 2015.

Pak, V.M., Keenan, B.T., Jackson, N., Grandner, M.A., Maislin, G., Teff, K., Schwab, R.J., Arnardottir, E.S., Juliusson, S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. International Journal of Obesity (London) 39(3): 472-479, 2015.

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Last updated: 08/11/2016
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