Allan I. Pack

faculty photo
John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Chief, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Itmat Expertise

Major interest is in genomic/genetic approaches to sleep and its disorders. Studies to identify genetic risk factors for the common disorder sleep apnea and what determines the individual differences in response to sleep deprivation are in progress. These studies are being complemented by investigations to identify molecular signatures for sleep apnea and sleep deprivation. The approach being taken is to identify dynamic changes in expression of candidate genes and also expression profiling in circulating leukocytes and monocytes across the sleep period or with sleep deprivation.

Selected Publications

Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow, C.J.: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake. Sleep 2017 (in press).

Kim, J., Pack, A.I., Riegel, B.J., Chirinos, J.A., Hanlon, A., Lee, S.K., and Shin, C.: Objecive snoring time and carotid intima-media thickness in non-apneic female snorers. Journal of Sleep Research 26(2): 147-150, Apr 2017 Notes: Dec 6. doi: 10.1111/jsr.12471. [Epub ahead of print]

Lyons, M.M., Keenan, B.T., Li, J., Khan, T., Elkasabanny, N., Walsh, C.M., Williams, N.N., Pack, A.I. and Gurubhagavatula, I.: Symptomless multi-variable apnea prediction index assesses obstructive sleep apnea risk and adverse outcomes in elective surgery. Sleep 40(3), Mar 2017 Notes: doi: 10.1093/sleep/zsw081.

Zimmerman, J.E., Chan, M.T., Lenz, O.T., Keenan, B.T., Maislin, G. and Pack, A.I.: Glutamate is a wake active neurotransmitter in Drosophila melanogaster. Sleep 2017 Notes: 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw046.

Matura, L.A., Fargo, J., Fritz, J.S., Smith, K.A., Vaidya, A., Pinder, D., Archer-Chicko, C., Palevsky, H.I., Pack, A.I., Sommers, M.S. and Kawut, S.M.: Slow-paced respiration therapy to treat symptoms in pulmonary arterial hypertension. Heart Lung 46(1): 7-13, 2017.

Watson, N.F., Buchwald, D., Delrow, J.J., Altemeier, W.A., Vitiello, M.V., Pack, A.I., Bamshad, M., Noonan, C. and Gharib, S.: Transcriptional signatures of sleep duration discordance in monozygotic twins. Sleep 2017 Notes: Jan 1;40(1). doi: 10.1093/sleep/zsw019.

Kalmbach, D.A., Schneider, L.D., Cheung, J., Bertrand, S.J., Kariharan, T., Pack, A.I. and Gehrman, P.R.: Genetic basis of chronotype in humans: Insights from three landmark GWAS. Sleep 2017 Notes: 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw048.

Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Yan, H., Dong, X., Chang, Y., Zhao, L., Zhang, X., Li, J., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis and obstructive sleep apnea in Chinese adults. Journal of Clinical Sleep Medicine 2017 Notes: Jan 26. pii: jc-00458-16. [Epub ahead of print]

Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop. Sleep 39(12): 2061-2075, Dec 2016.

Phan, T.S., Li, J.K., Segers, P., Reddy-Koppula, M., Akers, S.R., Kuna, S.T., Gislason, T., Pack, A.I. and Chirinos, J.A.: Aging is associated with an earlier arrival of reflected waves without a distal shift in reflection sites. Journal of the American Heart Association 5(9): pii: e003733, Aug 2016.

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Last updated: 04/18/2017
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