Julia C. Tchou

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Associate Professor of Clinical Surgery
Attending surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Course Director, Breast Surgery Elective, University of Pennsylvania School of Medicine, Philadelphia, PA
Breast Cancer Research Program Steering Committee, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Breast Surgery Section Chief, Hospital of the University of Pennsylvania
Co-Director, Rena Rowan Breast Center, Abramson Cancer Center
Department: Surgery

Contact information
Division of Endocrine & Oncologic Surgery
3400 Civic Center Boulevard
3rd Floor West
Philadelphia, PA 19104-4283
Office: 215-615-7575
Education:
B.S.
College of Mount Saint Vincent, Riverdale, NY, 1987.
Ph.D.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1993.
M.D.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1995.
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Description of Research Expertise

My research is focused on 1) developing strategies to mitigate breast cancer risk associated with metabolic syndrome by lifestyle modifications and by re-purposing some of the commonly prescribed medications to prevent breast cancer initiation and progression; 2) elucidating how novel immunotherapy such as CAR T therapy can induce epitope spreading and how combination therapy can unleash the anti-tumor effects of our own immune system; and 3) how we can use large data to enhance our understanding of tumor biology with the common goal of improving breast cancer outcomes.

Selected Publications

Tchou Julia, Zhao Yangbing, Levine Bruce L, Zhang Paul J, Davis Megan M, Melenhorst Jan Joseph, Kulikovskaya Irina, Brennan Andrea L, Liu Xiaojun, Lacey Simon F, Posey Avery D, Williams Austin D, So Alycia, Conejo-Garcia Jose R, Plesa Gabriela, Young Regina M, McGettigan Shannon, Campbell Jean, Pierce Robert H, Matro Jennifer M, DeMichele Angela M, Clark Amy S, Cooper Laurence J, Schuchter Lynn M, Vonderheide Robert H, June Carl H: Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer immunology research 5(12): 1152-1161, Dec 2017.

So Alycia, De La Cruz Lucy M, Williams Austin D, Bahng Joseph, Liao Geraldine, McDonald Elizabeth S, Fisher Carla S, Czerniecki Brian J, Sataloff Dahlia, Tchou Julia: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. Journal of surgical oncology Nov 2017.

Mustafa Rose E, DeStefano Lauren M, Bahng Joey, Yoon-Flannery Kahyun, Fisher Carla S, Zhang Paul J, Tchou Julia, Czerniecki Brian J, De La Cruz Lucy M: Evaluating the Risk of Upstaging HER2-Positive DCIS to Invasive Breast Cancer. Annals of surgical oncology 24(10): 2999-3003, Oct 2017.

Williams Austin D, So Alycia, Synnestvedt Marie, Tewksbury Colleen M, Kontos Despina, Hsiehm Meng-Kang, Pantalone Lauren, Conant Emily F, Schnall Mitchell, Dumon Kristoffel, Williams Noel, Tchou Julia: Mammographic breast density decreases after bariatric surgery. Breast cancer research and treatment 165(3): 565-572, Oct 2017.

Nabet Barzin Y, Qiu Yu, Shabason Jacob E, Wu Tony J, Yoon Taewon, Kim Brian C, Benci Joseph L, DeMichele Angela M, Tchou Julia, Marcotrigiano Joseph, Minn Andy J: Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell 170(2): 352-366.e13, Jul 2017.

Cochran J M, Chung S H, Leproux A, Baker W B, Busch D R, DeMichele A M, Tchou J, Tromberg B J, Yodh A G: Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy. Physics in medicine and biology 62(12): 4637-4653, Jun 2017.

Basta Marten N, Wu Liza C, Kanchwala Suhail K, Serletti Joseph M, Tchou Julia C, Kovach Stephen J, Fosnot Joshua, Fischer John P: Reliable prediction of postmastectomy lymphedema: The Risk Assessment Tool Evaluating Lymphedema. American journal of surgery 213(6): 1125-1133.e1, Jun 2017.

Gershuni Victoria, Li Yun R, Williams Austin D, So Alycia, Steel Laura, Carrigan Elena, Tchou Julia: Breast cancer subtype distribution is different in normal weight, overweight, and obese women. Breast cancer research and treatment 163(2): 375-381, Jun 2017.

Svoronos Nikolaos, Perales-Puchalt Alfredo, Allegrezza Michael J, Rutkowski Melanie R, Payne Kyle K, Tesone Amelia J, Nguyen Jenny M, Curiel Tyler J, Cadungog Mark G, Singhal Sunil, Eruslanov Evgeniy B, Zhang Paul, Tchou Julia, Zhang Rugang, Conejo-Garcia Jose R: Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer discovery 7(1): 72-85, Jan 2017.

Perales-Puchalt Alfredo, Svoronos Nikolaos, Rutkowski Melanie R, Allegrezza Michael J, Tesone Amelia J, Payne Kyle K, Wickramasinghe Jayamanna, Nguyen Jenny M, O'Brien Shane W, Gumireddy Kiranmai, Huang Qihong, Cadungog Mark G, Connolly Denise C, Tchou Julia, Curiel Tyler J, Conejo-Garcia Jose R: Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target. Clinical cancer research : an official journal of the American Association for Cancer Research 23(2): 441-453, Jan 2017.

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Last updated: 12/31/2017
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