Robert J. Levy

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
CHOP
Abramson Pediatric Research Center,
Room 702D
Philadelphia, PA 19104-4318
Office: 215-590-6119
Fax: 215-590-5454
Graduate Group Affiliations
Education:
M.D.
Johns Hopkins University School of Medicine, 1970.
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Description of Research Expertise

Research Summary
Heart Valve Disease: Research programs underway concerning the developmental basis for aortic valve disease, mechanistic studies of progression of calcific aortic stenosis, serotonin mechanisms in heart valve disease, and novel biomaterials for heart valve prostheses.

Gene delivery stents are an area of major interest: plasmid or viral vectors configured in sustained release preparations onto vascular stents for site specific vascular gene therapy.

Magnetic intravascular delivery of nanoparticles to treat arterial disease.

Description of Itmat Expertise

Dr. Levy's major research interests are heart valve disease, gene delivery stents, biomaterials and nanotechnology.

Selected Publications

Alferiev Ivan S, Iyer Radhika, Croucher Jamie L, Adamo Richard F, Zhang Kehan, Mangino Jennifer L, Kolla Venkatadri, Fishbein Ilia, Brodeur Garrett M, Levy Robert J, Chorny Michael: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.

Iyer Radhika, Croucher Jamie L, Chorny Michael, Mangino Jennifer L, Alferiev Ivan S, Levy Robert J, Kolla Venkatadri, Brodeur Garrett M: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer letters 360(2): 205-12, Feb 2015 Notes: [PubMed - as supplied by publisher]

Christian AJ, Alferiev IS, Connolly JM, Ischiropoulos H, Levy RJ.: The effects of the covalent attachment of 3-(4-hydroxy-3,5-di-tertbutylphenyl) propyl amine to glutaraldehyde pre-treated bovine pericardium on structural degeneration, oxidative modification and calcification of rat subdermal implants. J Biomed Mater Res A Jan 2015 Notes: in press; January 2015. [PubMed - as supplied by publisher]

Kruklitis RJ, Fishbein I, Singhal S, Kapoor V, Levy RJ, Sterman DH: Specific Transgene Administration to the Airway Epithelium and Management of Tracheobronchial Tumors. Respiration Oct [Epub ahead of print] 2014 Notes: [PubMed - as supplied by publisher]

Kruklitis RJ, Fishbein I, Singhal S, Kapoor V, Levy RJ, Sterman DH: Stent-mediated gene delivery for site-specific transgene administration to the airway epithelium and management of tracheobronchial tumors. Respiration 88(5): 406-17, Oct 2014 Notes: [PubMed - in process]

Hood Elizabeth D, Chorny Michael, Greineder Colin F, S Alferiev Ivan, Levy Robert J, Muzykantov Vladimir R: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.

Tengood JE, Alferiev IS, Zhang K, Fishbein I, Levy RJ, Chorny M.: Real-time disassembly analysis of composite magnetic nanoparticles in cells and biomimetic media. Proc Natl Acad Sci USA 11(11): 4245-50, Mar 2014 Notes: Pub Med in process.

Christian Abigail J, Lin Hongqiao, Alferiev Ivan S, Connolly Jeanne M, Ferrari Giovanni, Hazen Stanley L, Ischiropoulos Harry, Levy Robert J: The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials 35(7): 2097-102, Feb 2014.

Slee Joshua B, Alferiev Ivan S, Levy Robert J, Stachelek Stanley J: The use of the ex vivo Chandler Loop Apparatus to assess the biocompatibility of modified polymeric blood conduits. Journal of visualized experiments : JoVE(90), 2014.

Fishbein Ilia, Forbes Scott P, Adamo Richard F, Chorny Michael, Levy Robert J, Alferiev Ivan S: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of visualized experiments : JoVE(90), e51653, 2014.

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Last updated: 04/08/2015
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