Gregory P Bisson

faculty photo
Associate Professor of Medicine
Attending Physician, Philadelphia Veterans Affairs Medical Center
Senior Scholar, Department of Biostatistics and Epidemiology, Perelman School of Medicine
Department: Medicine

Contact information
832 Blockley Hall
423 Guardian Drive
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
Philadelphia, PA 19104-6021
Office: 215-573-5811
Fax: 215-573-5315
Graduate Group Affiliations
BA (Japanese)
University of Wisconsin-Madison, 1992.
University of Minnesota School of Medicine, 1997.
MSCE (Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2006.
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Description of Research Expertise

My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.

Description of Itmat Expertise

HIV infection, tuberculosis, cryptococcal meningitis, host-directed therapy, HIV treatment monitoring in resource-limited settings, drug resistance

Selected Publications

Ngongondo McNeil, Miyahara S, Hughes M, Sun X, Bisson GP, Gupta A, Kumwenda J, Lavenberg J, Torres T, Nyirenda M, Kidonge K, Hosseinpour C, AIDS Clinical Trials Group A5274: Hepatotoxicity during INH prophylaxis and ART in advanced HIV disease. JAIDS 2018.

Vujkovic M, Bellamy S, Zuppa A, Gastonguay M, Moorthy G, Ratshaa B, Han X, Steenhoff A, Mosepele M, Strom B, Bisson GP, Aplenc R, Gross R: "Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana." The Pharmacogenomics Journal 2018.

Vujkovic1 M, Bellamy S, Zuppa A, Gastonguay M, Moorthy G, Ratshaa B, Han X, Steenhoff AP, Mosepele M, Strom B, Aplenc R, Bisson GP, Gross R: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-treated HIV-Infected Patients in Botswana JAIDS: Journal of Acquired Immune Deficiency Syndromes 75(4): 488-491, August 2017.

Vinnard C, Ravimohan S, Neo T, Pasipanodya J, Kant S, Modongo C, Zetola N, Weissman D, Gumbo T, Bisson GP: Markers of Gut Dysfunction Do Not Explain Low Rifampicin Bioavailability in HIV-Associated TB. Journal of Antimicrobial Chemotherapy 72(7): 2020-2027, July 2017.

Gregory P. Bisson, Ritesh Ramchandani, Sachiko Miyahara, Rosie Mngqibisa, Mitch Matoga, McNeil Ngongondo, Wadzanai Samaneka, Lucy Koech, Kogieleum Naidoo, Mohammed Rassool, Fredrick Kirui, Peter Banda, Vidya Mave, Dileep Kadam, Paul Leger, German Henostroza, Yukari C. Manabe, Jing Bao, Johnstone Kumwenda, Amita Gupta, Mina C. Hosseinipour, for the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team : Risk Factors for Early Mortality on Antiretroviral Therapy in Advanced HIV-Infected Adults AIDS July 2017.

Ravimohan1 S Tamuhla N, Nfanyana K, Ni H, Steenhoff AP, Gross R, Weissman D, Bisson GP: Elevated pre-ART CD39+CD8+ T-cell frequency is associated with early mortality in advanced HIV/TB. Clinical Infectious Diseases 15(64): 1453-1456, May 2017.

Christopher Vinnard, Shruthi Ravimohan, Neo Tamuhla, Jotam Pasipanodya, Shashikant Srivastava, Chawa Modongo, Nicola M. Zetola, Drew Weissman, Tawanda Gumbo, Gregory P. Bisson: Pyrazinamide Clearance is Impaired among HIV/Tuberculosis Patients with High Levels of Systemic Immune Activation. PLoS ONE In press, 2017.

Hosseinipour MC*, Bisson GP*, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A and the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial. The Lancet 387 (10024): 1198-209, March 2016 Notes: *Contributed equally.

C Vinnard, Ravimohan S, Tamuhla N, Ivaturi V, Pasipanodya J, Kant S, Weissman D, Gumbo T, Bisson GP: Immune Activation and Isoniazid Metabolism in HIV-associated Tuberculosis. British Journal of Clinical Pharmacology Page: bcp.13172, October 2016 Notes: Epub ahead of print.

Han JH, Gordon K, Womack JA, Gibert CL, Leaf DA, Rimland D, Rodriquez-Barradas MC, Bisson GP : Comparative Effectiveness of Diabetic Oral Medications among HIV-Infected and HIV-Uninfected Veterans. Diabetes Care Page: pii: dc160718, September 2016 Notes: Epub ahead of print.

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Last updated: 06/06/2018
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