Hamid Bassiri

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
3501 Civic Center Blvd.
Colket Translational Research Bldg, Room 3014
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-425-2133
Fax: 215-590-3770
Lab: 267-426-7626
Graduate Group Affiliations
Education:
BA (Biology)
University of Pennsylvania, 1991.
PhD (Immunology)
University of Pennsylvania School of Medicine, 2002.
MD
University of Pennsylvania School of Medicine, 2004.
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Description of Research Expertise

RESEARCH INTERESTS:
Our lab is interested in mechanisms of tumor immune surveillance and ways to harness the activity of innate lymphocytes for cellular cancer immunotherapy. The current projects in the lab include:
1) Directing natural killer T cell anti-tumor responses
2) Alterations in tumor microenvironment with polyamine antagonism
3) Mechanisms of chimeric antigen receptor T cell-mediated cytokine storm syndrome
4) Effect of augmenting TCR-mediated signals in chronic viral infections

KEYWORDS:
Natural killer T cells
Tumor microenvironment
Cellular immunotherapy

LAB PERSONNEL:
Jennie Altman (Lab manager and Research technician)
Adriana Benavides (Post-doctoral fellow)
Gabrielle Ferry (Research technician)

Description of Itmat Expertise

Natural killer T cells
Immunotherapy
Chimeric antigen receptors
T cell tolerance
Autoimmunity

Selected Publications

Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.: iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunology Research 2(1): 59-69, Jan 2014.

Bassiri H, Das R, Nichols KE.: Invariant NKT cells: Killers and conspirators against cancer. OncoImmunology 2(12): e27440, Dec 2013.

Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong M-C, Veillette A, Orange JS, Nichols KE.: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17): 3386-3395, Feb 2013.

May RM, Okumura M, Hsu C-J, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T.: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood 121(16): 3135-3146, Feb 2013.

Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL.: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of Immunology 182(3): 1370-8, Feb 2009.

Nunez-Cruz S, Yeo WCJ, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE.: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of Immunology 181(4): 2311-20, Aug 2008.

Bassiri H, Janice YWC, Rothman J, Koretzky GA, Nichols KE.: X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic Research 42(1-3): 145-59, 2008.

Bassiri H, Carding SR.: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of Immunology 166(10): 5945-54, May 2001.

Reya T, Bassiri H, Biancaniello R, Carding SR.: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental Immunology 5(4): 287-302, 1998 Notes: Shared first authorship.

Contractor NV, Bassiri H, Reya T, Park AY, Baumgart DC, Wasik MA, Emerson SG, Carding SR.: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of Immunology 160(1): 385-94, Jan 1998 Notes: Shared first authorship.

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Last updated: 08/05/2015
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