Hamid Bassiri

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
3501 Civic Center Blvd.
Colket Translational Research Bldg, Room 3014
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-425-2133
Education:
BA (Biology)
University of Pennsylvania, 1991.
PhD (Immunology)
University of Pennsylvania School of Medicine, 2002.
MD
University of Pennsylvania School of Medicine, 2004.
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Description of Research Expertise

Immunology
T cell development
Tumor biology
Natural killer T cells

Description of Itmat Expertise

Natural killer T cells
Immunotherapy
Chimeric antigen receptors
T cell tolerance
Autoimmunity

Selected Publications

Das Rupali, Bassiri Hamid, Guan Peng, Wiener Susan, Banerjee Pinaki P, Zhong Ming-Chao, Veillette André, Orange Jordan S, Nichols Kim E: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood Feb 2013 Notes: Epub ahead of print Feb 21 2013.

May Rebecca M, Okumura Mariko, Hsu Chin-Jung, Bassiri Hamid, Yang Enjun, Rak Gregory, Mace Emily M, Philip Naomi H, Zhang Weiguo, Baumgart Tobias, Orange Jordan S, Nichols Kim E, Kambayashi Taku: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood Feb 2013 Notes: Epub ahead of print Feb 13 2013

Cen Osman, Ueda Aki, Guzman Laura, Jain Jimmy, Bassiri Hamid, Nichols Kim E, Stein Paul L: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of immunology (Baltimore, Md. : 1950) 182(3): 1370-8, Feb 2009.

Bassiri Hamid, Janice Yeo W C, Rothman Jennifer, Koretzky Gary A, Nichols Kim E: X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic research 42(1-3): 145-59, 2008.

Nunez-Cruz Selene, Yeo W C Janice, Rothman Jennifer, Ojha Priti, Bassiri Hamid, Juntilla Marisa, Davidson Dominique, Veillette André, Koretzky Gary A, Nichols Kim E: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of immunology (Baltimore, Md. : 1950) 181(4): 2311-20, Aug 2008.

Bassiri H, Carding S R: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of immunology (Baltimore, Md. : 1950) 166(10): 5945-54, May 2001.

Reya T, Bassiri H, Biancaniello R, Carding S R: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental immunology 5(4): 287-302, 1998 Notes: Shared first authorship.

Li B, Bassiri H, Rossman M D, Kramer P, Eyuboglu A F, Torres M, Sada E, Imir T, Carding S R: Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950) 161(3): 1558-67, Aug 1998.

Contractor N V, Bassiri H, Reya T, Park A Y, Baumgart D C, Wasik M A, Emerson S G, Carding S R: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 160(1): 385-94, Jan 1998 Notes: Shared first authorship.

Samoilova E B, Horton J L, Bassiri H, Zhang H, Linsley P S, Carding S R, Chen Y: B7 blockade prevents activation-induced cell death of thymocytes. International immunology 9(11): 1663-8, Nov 1997.

Bassiri H, Nichols K E: X-linked lymphoproliferative disease (XLP). Atlas of Genetics and Cytogenetics in Oncology and Haematology April 2012 Notes: http://AtlasGeneticsOncology.org/Kprones/XlinkedlymphoproliferID10028.html.

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Last updated: 08/08/2013
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