Geoffrey Karl Aguirre

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Associate Professor of Neurology
Associate Director, Penn Center for Neuroscience and Society
Assistant Directory Neurology Residency, Department of Neurology
Department: Neurology

Contact information
Department of Neurology
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3390
Fax: 215-349-8260
Graduate Group Affiliations
Education:
BA (Politics)
Princeton University, 1992.
PhD (Neuroscience)
University of Pennsylvania, 2000.
MD
University of Pennsylvania, 2001.
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Description of Research Expertise

I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.

Selected Publications

Datta Ritobrato, Aguirre Geoffrey K, Hu Siyuan, Detre John A, Cucchiara Brett: Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura. Cephalalgia 33(6): 365-74, Apr 2013.

Butt Omar H, Benson Noah C, Datta Ritobrato, Aguirre Geoffrey K: The fine-scale functional correlation of striate cortex in sighted and blind people. The Journal of Neuroscience 33(41): 16209-19, 2013.

Cucchiara Brett, Wolf Ronald L, Nagae Lidia, Zhang Quan, Kasner Scott, Datta Ritobrato, Aguirre Geoffrey K, Detre John A: Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PloS one 8(7): e71007, 2013.

Benson Noah C, Butt Omar H, Datta Ritobrato, Radoeva Petya D, Brainard David H, Aguirre Geoffrey K: The retinotopic organization of striate cortex is well predicted by surface topology. Current biology 22(21): 2081-5, Nov 2012.

Kahn David Alexander, Aguirre Geoffrey Karl: Confounding of norm-based and adaptation effects in brain responses. NeuroImage 60(4): 2294-9, May 2012.

Datta Ritobrato, Lee Jongho, Duda Jeffrey, Avants Brian B, Vite Charles H, Tseng Ben, Gee James C, Aguirre Gustavo D, Aguirre Geoffrey K: A digital atlas of the dog brain. PloS one 7(12): e52140, 2012.

Datta Ritobrato, Detre John A, Aguirre Geoffrey K, Cucchiara Brett: Absence of changes in cortical thickness in patients with migraine. Cephalalgia : an international journal of headache 31(14): 1452-8, Oct 2011.

Aleman Tomas S, Cideciyan Artur V, Aguirre Geoffrey K, Huang Wei Chieh, Mullins Cristina L, Roman Alejandro J, Sumaroka Alexander, Olivares Melani B, Tsai Frank F, Schwartz Sharon B, Vandenberghe Luk H, Limberis Maria P, Stone Edwin M, Bell Peter, Wilson James M, Jacobson Samuel G: Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model. Investigative ophthalmology & visual science 52(9): 6898-910, Aug 2011.

Aguirre Geoffrey Karl, Mattar Marcelo Gomes, Magis-Weinberg Lucía: de Bruijn cycles for neural decoding. NeuroImage 56(3): 1293-300, Jun 2011.

Morgan Lindsay K, Macevoy Sean P, Aguirre Geoffrey K, Epstein Russell A: Distances between real-world locations are represented in the human hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(4): 1238-45, Jan 2011.

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Last updated: 04/04/2014
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