Sharyn I. Katz

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Active Staff Physician, Penn-Presbyterian Medical Center
Attending Staff, Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Department of Radiology
Hospital of the University of Pennsylvania
One Silverstein Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-6724
B.A. (Chemistry and Biology)
College of the Holy Cross, 1992.
M.D. (Doctor of Medicine)
Rush University, Rush Medical College, 1999.
MTR (Translational Reserch)
University of Pennsylvania, 2011.
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Description of Research Expertise

During my Masters in Translational Research (MTR), the focus of my thesis was imaging of small animal models of thoracic malignancy and, through the graduate level courses in cell biology, genetics and cancer biology and under the guidance of Dr. Wafik El-Deiry, M.D. Ph.D. an internationally recognized and accomplished physician-scientist, I have established and characterized working animal models of human thoracic malignancy. Using these animal models I generated clinically relevant hypotheses regarding the variables that may impact imaging biomarkers. Thus far my research has centered on FLT-PET as a marker of therapeutic response.

As part of the MTR program, I have been trained in the basics of clinical research protocol design, the regulatory process, and studied the ethical issues in clinical research. With this training, I wrote two pilot clinical trial protocols resulting in the performance of the first-in-man FLT-PET exam at the University of Pennsylvania several years ago.

Current projects are focused on defining the variables that impact on FLT-PET as a marker of therapeutic response in non-small cell lung cancer.

Description of Itmat Expertise

My research focuses on the development of novel molecular imaging probes to assess tumor response to therapy in thoracic malignancy using in vitro and in vivo models. The goal is to identify and translate promising oncologic imaging probes to the clinic. Currently I am studying FLT-PET/CT, a marker of cellular proliferation.
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Last updated: 10/15/2013
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