Rong Zhou

faculty photo
Research Associate Professor of Radiology
Member, Institute of Translational Medicine and Therapeutics (ITMAT) , University of Pennsylvania
Member, Institute of Regenerative Medicine, University of Pennsylvania
Department: Radiology

Contact information
B6 Blockley Hall
422 Currie Blvd
Philadelphia, PA 19104
Office: (215)-746-8747
Fax: 215-573-2113
Lab: (215)-746-8751
BS (Biomedical Engineering)
Shanghai Jiao Tong University, 1987.
PhD (Biophysics /Magnetic Resonance)
State University of New York at Buffalo, 1998.
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Description of Research Expertise

Magnetic resonance imaging and spectroscopy
Molecular imaging of cancer and cardiovascular disease
Stem cells and cardiac repair

Description of Itmat Expertise

Dr. Zhou is directing a Cardiovascular Imaging Program focusing on small animal models. Within this program, an array of non-invasive imaging techniques have been developed /optimized on small animals including in vivo left ventricular global function, wall motion, and myocardial blood flow estimated by arterial spin labeling and DCE-MRI combined with kinetic modeling.

This program has been funded by NIH and Sate of Pennsylvania to examine stem cell-based myocardial regeneration in preclinical models. Her laboratory is able to generate highly enriched cardiomyocytes derived from murine embryonic stem cells in large quantities for in vivo studies. Her laboratory is developing molecular imaging techniques including nanoparticles, reporter gene approaches, hyperpoloarized carbon-13 techniques for studying various aspects of cardiovascular diseases.

Selected Publications

Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 4(1): 33-41, 2011.

Zhou R, Idiyatullin D, Moeller S, Corum C, Zhang H, Qiao H, Zhong J, Garwood M : SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium. Magnetic Resonance in Medicine 63: 1154-1161, 2010.

Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken A, Schmitz A, Kung HF, Ferrari VA, and Zhou R: Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection. Radiology 250(3): 821-829, 2009.

Zhou R, Acton PD, Ferrari VA: Imaging Stem Cells Implanted in Infarcted Myocardium. Journal of American College of Cardiology 48(10): 2094-2106, 2006.

Li LZ*, Zhou R*, Xu HN, Moon L, Zhong T, Kim EJ, Qiao H, Reddy R, Leeper D, Chance B, Glickson JD.: Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci USA 106(16): 6608-13, 2009 Notes: *equal contributing 1st authors.

Qiao H, Surti S, Choi SR, Raju K, Zhang H, Ponde DE, Kung HF, Karp JS, Zhou R: Death and proliferation time course of stem cells transplanted in the myocardium. Molecular Imaging and Biology 11: 408-414, 2009.

Zhou R, Thomas DT, Qiao H, Bal H, Choi SR, Alavi A, Ferrari VA, Kung HF and Acton PD.: In vivo Detection of Stem Cells Grafted in the Infarcted Rat Myocardium. Journal of Nuclear Medicine 46: 816-822, 2005.

Zhou R, Pickup S, Yankeelov T, Springer Jr. CS, Glickson JD : Simultaneous measurement of AIF and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magnetic Resonance in Medicine 52: 248-257, 2004.

Zhou R, Steve Pickup, Jerry Glickson, Craig Scott and Victor Ferrari : Assessment of Global and Regional Myocardial Function in the Mouse Using Cine and Tagged MRI. Magnetic Resonance in Medicine 49: 760-764, 2003.

Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, Molkentin JD, Radice GL: Induced deletion of the N-Cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Research 96: 346-354, 2005.

Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, and Epstein JA: Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest 112: 863-871, 2003.

Abtahian F, Guerriero A, Lu M, Zhou R, Mocsai A, Myers E, Huang B, Jackson D, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, and Kahn M: Separation of blood and lymphatic vascular networks is regulated by the hematopoietic signaling proteins SLP-76 and SYK. Science 299: 247-251, 2003.

Zhou R, Mazurchuk R, and Straubinger RM: Anti-vasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model. Cancer Research 62: 2561-2566, 2002.

Auricchio A, Zhou R, Wilson J, Glickson J: In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proceeding of National Academy of Science (USA) 98: 5205-5210, 2001.

Zhou R, Bansal N, Leeper DB, Glickson JD : Intracellular acidification of human melanoma xenografts by respiratory inhibitor meta-iodobenzylguanidine plus hyperglycemia: a 31P magnetic resonance spectroscopy study. Cancer Research 60: 3532-3536, 2000.

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Last updated: 05/21/2015
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