Ravi K Amaravadi

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Member, Institute of Translational Medicine and Therapeutics
Member, Abramson Cancer Center
Member, University of Pennsylvania GI Center for Molecular Studies of Digestive and Liver Diseases
Co-Leader Cancer Therapeutics Program , Abramson Cancer Center, University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-201
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-7402
Fax: 215-349-8550
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
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Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Itmat Expertise

Dr. Amaravadi conducts basic, preclinical and Phase I/II clinical trials in novel molecularly targeted therapeutics and combinations in cancer therapy.

Selected Publications

Devorkin L, Amaravadi RK, Winkler JD, Lum JJ: Autophagy inhibition enhances sunitinib efficacy in clear cell ovarian carcinoma Molecular Cancer Research 2016 accepted.

Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, Vonderheide RH, Maity A, Wherry EJ, Minn AJ.: Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell 167(6): 1540-1554, Dec 2016.

Kong Jianping, Whelan Kelly A, Laczkó Dorottya, Dang Brendan, Caro Monroig Angeliz, Soroush Ali, Falcone John, Amaravadi Ravi K, Rustgi Anil K, Ginsberg Gregory G, Falk Gary W, Nakagawa Hiroshi, Lynch John P: Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Molecular carcinogenesis 55(11): 1526-1541, Nov 2016.

Zhang Gao, Frederick Dennie T, Wu Lawrence, Wei Zhi, Krepler Clemens, Srinivasan Satish, Chae Young Chan, Xu Xiaowei, Choi Harry, Dimwamwa Elaida, Ope Omotayo, Shannan Batool, Basu Devraj, Zhang Dongmei, Guha Manti, Xiao Min, Randell Sergio, Sproesser Katrin, Xu Wei, Liu Jephrey, Karakousis Giorgos C, Schuchter Lynn M, Gangadhar Tara C, Amaravadi Ravi K, Gu Mengnan, Xu Caiyue, Ghosh Abheek, Xu Weiting, Tian Tian, Zhang Jie, Zha Shijie, Liu Qin, Brafford Patricia, Weeraratna Ashani, Davies Michael A, Wargo Jennifer A, Avadhani Narayan G, Lu Yiling, Mills Gordon B, Altieri Dario C, Flaherty Keith T, Herlyn Meenhard: Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. The Journal of clinical investigation 126(5): 1834-56, May 2016.

Budina-Kolomets Anna, Webster Marie R, Leu Julia I-Ju, Jennis Matthew, Krepler Clemens, Guerrini Anastasia, Kossenkov Andrew V, Xu Wei, Karakousis Giorgos, Schuchter Lynn, Amaravadi Ravi K, Wu Hong, Yin Xiangfan, Liu Qin, Lu Yiling, Mills Gordon B, Xu Xiaowei, George Donna L, Weeraratna Ashani T, Murphy Maureen E: HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer research 76(9): 2720-30, May 2016.

Gade T, Tucker E, Nakazawa M, Hunt S, Wong W, Krock B, Weber C, Nadolski GJ, Clark TW,Amaravadi RK, Winkler JD,Soulen M, Furth EM, Simon MC : Severe Ischemia Induces Quiescence and Autophagy Dependence in Surviving Hepatocellular Carcinoma Cells Radiology in press , 2016.

Twyman-Saint Victor C, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, Xu B, Dada H, Odiorizzi P, Herati R, Mansfield K, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma D, Xu X, Feldman M, Gangadhar T, Hahn S, Wherry JE, Vonderheide R, Benci J, Minn A. : Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer. Nature Mar 2015 Notes: [Epub ahead of print]

Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA.: A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. Molecular Cancer Therapeutics Sept 2015.

Amaravadi RK, Hamilton KE, Ma X, Piao S, Portillo AD, Nathanson KL, Carlino MS, Long GV, Puzanov I, Xu X, Morrissette JJ, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR.: Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors. Clinical Cancer Research Jul 2015.

Flaherty KT, Hamilton BK, Rosen MA, Amaravadi RK, Schuchter LM, Gallagher M, Chen H, Sehgal C, O'Dwyer PJ. : Phase I/II Trial of Imatinib and Bevacizumab in Patients With Advanced Melanoma and Other Advanced Cancers. The Oncologist June 2015.

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Last updated: 12/05/2016
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