Ravi K Amaravadi

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Member, Institute of Translational Medicine and Therapeutics
Member, Abramson Cancer Center
Member, University of Pennsylvania GI Center for Molecular Studies of Digestive and Liver Diseases
Co-Leader Cancer Therapeutics Program , Abramson Cancer Center, University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-201
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-7402
Fax: 215-349-8550
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
Permanent link
 

Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Itmat Expertise

Dr. Amaravadi conducts basic, preclinical and Phase I/II clinical trials in novel molecularly targeted therapeutics and combinations in cancer therapy.

Selected Publications

Lu Hezhe, Liu Shujing, Zhang Gao, Bin Wu , Zhu Yueyao, Frederick Dennie T, Hu Yi, Zhong Wenqun, Randell Sergio, Sadek Norah, Zhang Wei, Chen Gang, Cheng Chaoran, Zeng Jingwen, Wu Lawrence W, Zhang Jie, Liu Xiaoming, Xu Wei, Krepler Clemens, Sproesser Katrin, Xiao Min, Miao Benchun, Liu Jianglan, Song Claire D, Liu Jephrey Y, Karakousis Giorgos C, Schuchter Lynn M, Lu Yiling, Mills Gordon, Cong Yusheng, Chernoff Jonathan, Guo Jun, Boland Genevieve M, Sullivan Ryan J, Wei Zhi, Field Jeffrey, Amaravadi Ravi K, Flaherty Keith T, Herlyn Meenhard, Xu Xiaowei, Guo Wei: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature Sep 2017.

Ndoye Abibatou, Budina-Kolomets Anna, Kugel Curtis H, Webster Marie R, Kaur Amanpreet, Behera Reeti, Rebecca Vito W, Li Ling, Brafford Patricia A, Liu Qin, Vashisht Gopal Y N, Davies Michael A, Mills Gordon B, Xu Xiaowei, Wu Hong, Herlyn Meenhard, Nicastri Michael C, Winkler Jeffrey D, Soengas Maria S, Amaravadi Ravi K, Murphy Maureen E, Weeraratna Ashani T: ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma. Cancer research Sep 2017.

Zhang Ying, Kurupati Raj, Liu Ling, Zhou Xiang Yang, Zhang Gao, Hudaihed Abeer, Filisio Flavia, Giles-Davis Wynetta, Xu Xiaowei, Karakousis Giorgos C, Schuchter Lynn M, Xu Wei, Amaravadi Ravi, Xiao Min, Sadek Norah, Krepler Clemens, Herlyn Meenhard, Freeman Gordon J, Rabinowitz Joshua D, Ertl Hildegund C J: Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell 32(3): 377-391.e9, Sep 2017.

Rebecca Vito W, Nicastri Michael C, McLaughlin Noel, Fennelly Colin, McAfee Quentin, Ronghe Amruta, Nofal Michel, Lim Chun-Yan, Witze Eric, Chude Cynthia I, Zhang Gao, Alicea Gretchen M, Piao Shengfu, Murugan Sengottuvelan, Ojha Rani, Levi Samuel M, Wei Zhi, Barber-Rotenberg Julie S, Murphy Maureen E, Mills Gordon B, Lu Yiling, Rabinowitz Joshua, Marmorstein Ronen, Liu Qin, Liu Shujing, Xu Xiaowei, Herlyn Meenhard, Zoncu Roberto, Brady Donita C, Speicher David W, Winkler Jeffrey D, Amaravadi Ravi K: A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer discovery Sep 2017.

Gangadhar Tara C, Savitch Samantha L, Yee Stephanie S, Xu Wei, Huang Alexander C, Harmon Shannon, Lieberman David B, Soucier Devon, Fan Ryan, Black Taylor A, Morrissette Jennifer J D, Salathia Neeraj, Waters Jill, Zhang Shile, Toung Jonathan, van Hummelen Paul, Fan Jian-Bing, Xu Xiaowei, Amaravadi Ravi K, Schuchter Lynn M, Karakousis Giorgos C, Hwang Wei-Ting, Carpenter Erica L: Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma. Pigment cell & melanoma research Aug 2017.

Whelan K A, Chandramouleeswaran P M, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, Darling D S, Kita Y, Natsugoe S, Winkler J D, Klein-Szanto A J, Amaravadi R K, Avadhani N G, Rustgi A K, Nakagawa H: Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene 36(34): 4843-4858, Aug 2017.

Izar Benjamin, Sharfman William, Hodi F Stephen, Lawrence Donald, Flaherty Keith T, Amaravadi Ravi, Kim Kevin B, Puzanov Igor, Sosman Jeffrey, Dummer Reinhard, Goldinger Simone M, Lam Lyhping, Kakar Shefali, Tang Zhongwen, Krieter Oliver, McDermott David F, Atkins Michael B: A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status. Cancer medicine 6(8): 1904-1914, Aug 2017.

Scott Emma C, Maziarz Richard T, Spurgeon Stephen E, Medvedova Eva, Gajewski James, Reasor-Heard Shara, Park Byung, Kratz Anne, Thomas George V, Loriaux Marc, Cascio Michael, Podolak Jennifer, Gordon Miranda, Botelho Jennifer, Stadtmauer Edward, Amaravadi Ravi, Vogl Dan T: Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma. Haematologica 102(7): e261-e265, Jul 2017.

Vijayaraghavan Smruthi, Karakas Cansu, Doostan Iman, Chen Xian, Bui Tuyen, Yi Min, Raghavendra Akshara S, Zhao Yang, Bashour Sami I, Ibrahim Nuhad K, Karuturi Meghan, Wang Jing, Winkler Jeffrey D, Amaravadi Ravi K, Hunt Kelly K, Tripathy Debu, Keyomarsi Khandan: CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers. Nature communications 8: 15916, Jun 2017.

Frazier J, Bertout JA, Kerwin WS, Moreno-Gonzalez A, Casalini JR, Grenley MO, Beirne E, Watts KL, Keener A, Thirstrup DJ, Tretyak I, Ditzler S, Tripp CD, Choy K, Gillings S, Breit MN, Meleo KA, Rizzo V, Herrera CL, Perry JA, Amaravadi RK, Olson JM, Klinghoffer R: Multi-drug analyses in patients distinguish efficacious cancer agents based on both tumor cell killing and immunomodulation. Cancer Research pii: canres.0084.2017, Mar 2017.

back to top
Last updated: 09/28/2017
The Trustees of the University of Pennsylvania