Intae Lee

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Research Assistant Professor of Radiation Oncology
Investigator, IFEM, Department of Physiology, University of Pennsylvania
Department: Radiation Oncology

Contact information
3620 Hamilton Walk
1 John Morgan Building
Philadelphia, PA 19104
Office: 215-898-9100
Fax: 215-898-0868
Lab: 215-898-8692
Education:
M.S. (Biophysical Sciences)
University of Minnesota, 1986.
Ph.D. (Biophysical Sciences)
University of Minnesota, 1988.
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Description of Itmat Expertise

1. Oxidative stress (ROS) and NOX2
2. Acute lung injury (ALI)
3. Toxicology and drug development
4. Animal models of diseases
5. Tumor pathophysiology
6. Radiation biology

Selected Publications

Lee Intae, Dodia Chandra, Chatterjee Shampa, Feinstein Sheldon I, Fisher Aron B: Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2). American journal of physiology. Lung cellular and molecular physiology 306(7): L635-44, Apr 2014.

Lee Intae, Dodia Chandra, Chatterjee Shampa, Zagorski John, Mesaros Clementina, Blair Ian A, Feinstein Sheldon I, Jain Mahendra, Fisher Aron B: A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung. The Journal of pharmacology and experimental therapeutics 345(2): 284-96, May 2013.

Lee, J., Sunar, U., Tuttle, S., Shogen, K., Lee, I.: Differential effect of 1-buthionine sulfoximide ± ranpirnase on human lung cancer and lung fibroblast cells. Cancer Therapy 7: 454-463, 2009.

Lee, I., Shogen, K.: Mechanisms of enhanced tumoricidal efficacy of mulitple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer. Cancer Chemotherapy & Pharmacology 62: 337-346, 2008.

Lee, I., Kalota, A., Gewirtz, A.M., Shogen K.: Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice. Anticancer Res. 27: 299-308, 2007.

Kim, D.H., Kim, E.J., Kalota, A., Gewirtz, A.M., Glickson, J., Shogen, K., Lee, I.: Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase®, on A549 human lung cancer xenografts of nude mice. Adv. in Exp. Med. Biol. 599: 53-60, 2007.

Lee, I., Kim, D.H., Sunar, U., Magnitsky, S., Shogen, K.: The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer. IN VIVO 21: 721-728, 2007.

Wu, S.P., Lee, I., Ghoroghchian, P.P., Frail, P.R., Zheng, G., Glickson, J.D., Therien, M.: Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris [(porphinato) zink(II)] fluorophores. Bioconjugate Chem. 16: 542-550, 2005.

Donnelly, E.T., Liu, Y., Fatunmbi, Y.O., Lee, I., Magda, D., Rockwell, S.: Effects of Texaphyrines on the oxygenation of EMT6 mouse mammary tumors. Int. J. Radiat. Oncol. Biol. Phys. 58: 1570-1576, 2004.

Lee, I., Lee, Y.H., Mikulski, S.M., Shogen, K.: Effect of onconase ± tamoxifen on ASPC-1 human pancreatic tumors in nude mice. Adv. in Exp. Med. & Biol. 530: 187-196, 2003.

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Last updated: 05/21/2014
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