Mortimer Poncz

faculty photo
Professor of Pediatrics
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Department: Pediatrics

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Graduate Group Affiliations
Columbia University, 1972.
University of Pennsylvania, 1976.
Permanent link

Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Description of Itmat Expertise

Platelet biology in regulating thrombosis using novel approaches for the targeted delivery of coagulation, anti-thrombotic and anti-angiogenic agents.

Selected Publications

Madeeva Daria, Cines Douglas B, Poncz Mortimer, Rauova Lubica: Role of monocytes and endothelial cells in heparin-induced thrombocytopenia. Thrombosis and haemostasis 116(5): 806-812, Oct 2016.

Bdeir Khalil, Gollomp Kandace, Stasiak Marta, Mei Junjie, Papiewska-Pajak Izabela, Zhao Guohua, Worthen G Scott, Cines Douglas B, Poncz Mortimer, Kowalska M Anna: Platelet-specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. American journal of respiratory cell and molecular biology Oct 2016.

Wang Qi, You Tao, Fan Hongqiong, Wang Yinyan, Chu Tinatian, Poncz Mortimer, Zhu Li: Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets Page: 1-8, Aug 2016.

Khandelwal Sanjay, Lee Grace M, Hester C Garren, Poncz Mortimer, McKenzie Steven, Sachais Bruce S, Rauova Lubica, Kelsoe Garnett, Cines Douglas B, Frank Michael, Arepally Gowthami M: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood Jul 2016.

Ostertag Eric M, Bdeir Khalil, Kacir Stephen, Thiboutot Michelle, Gulendran Gayathri, Yunk Lenka, Hayes Vincent M, Motto David G, Poncz Mortimer, Zheng X Long, Cines Douglas B, Siegel Don L: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56(7): 1775-85, Jul 2016.

Greineder Colin F, Hood Elizabeth D, Yao Anning, Khoshnejad Makan, Brenner Jake S, Johnston Ian H, Poncz Mortimer, Gottstein Claudia, Muzykantov Vladimir R: Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of controlled release : official journal of the Controlled Release Society 226: 229-237, Feb 2016.

Zhang Nanyan, Zhi Huiying, Curtis Brian R, Rao Sridhar, Jobaliya Chintan, Poncz Mortimer, French Deborah L, Newman Peter J: CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood 127(6): 675-80, Feb 2016.

Parker Zahra Folasade, Rux Ann H, Riblett Amber M, Lee Fang-Hua, Rauova Lubica, Cines Douglas B, Poncz Mortimer, Sachais Bruce S, Doms Robert W: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS research and human retroviruses 32(7): 705-17, Feb 2016.

Sim Xiuli, Poncz Mortimer, Gadue Paul, French Deborah L: Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood 127(10): 1227-33, Jan 2016.

Tutwiler Valerie, Madeeva Daria, Ahn Hyun Sook, Andrianova Izabella, Hayes Vincent, Zheng X Long, Cines Douglas B, McKenzie Steven E, Poncz Mortimer, Rauova Lubica: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood 127(4): 464-72, Jan 2016.

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Last updated: 12/22/2016
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