Andrew Tsourkas

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Professor of Bioengineering
Department: Bioengineering

Contact information
Department of Bioengineering
University of Pennsylvania
210 S. 33rd Street, 240 Skirkanich Hall
Philadelphia, PA 19104
Office: 215-898-8167
Fax: 215-573-2071
B.S. (Mechanical Engineering)
Cornell University, 1997.
M.S. (Mechanical Engineering)
Johns Hopkins University, 1999.
Ph.D. (Biomedical Engineering)
Georgia Institute of Technology/Emory University, 2004.
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Description of Research Expertise

Research Interests: Developing molecular imaging probes to improve the diagnostic yield of non- or minimally-invasive imaging procedures and diagnostic assays.

Keywords: Molecular imaging, probes, contrast agents, magnetic resonance, fluorescence, bioluminescence

Description of Itmat Expertise

Dr. Tsourkas' laboratory is developing molecular imaging probes to aid in the study and detection of diseased states in vivo.

Selected Publications

Elias Drew R, Poloukhtine Andrei, Popik Vladimir, Tsourkas Andrew: Effect of ligand density, receptor density, and nanoparticle size on cell targeting. Nanomedicine : nanotechnology, biology, and medicine Jun 2012.

Czupryna Julie, Tsourkas Andrew: Xanthine oxidase-generated hydrogen peroxide is a consequence, not a mediator of cell death. The FEBS journal 279(5): 844-55, Mar 2012.

Crayton Samuel H, Elias Drew R, Al Zaki Ajlan, Cheng Zhiliang, Tsourkas Andrew: ICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance. Biomaterials 33(5): 1509-19, Feb 2012.

Crayton Samuel H, Tsourkas Andrew: pH-titratable superparamagnetic iron oxide for improved nanoparticle accumulation in acidic tumor microenvironments. ACS nano 5(12): 9592-601, Dec 2011.

Cheng Zhiliang, Elias Drew R, Kamat Neha P, Johnston Eric D, Poloukhtine Andrei, Popik Vladimir, Hammer Daniel A, Tsourkas Andrew: Improved tumor targeting of polymer-based nanovesicles using polymer-lipid blends. Bioconjugate chemistry 22(10): 2021-9, Oct 2011.

Thorek Daniel L J, Weisshaar Christine L, Czupryna Julie C, Winkelstein Beth A, Tsourkas Andrew: Superparamagnetic iron oxide-enhanced magnetic resonance imaging of neuroinflammation in a rat model of radicular pain. Molecular imaging 10(3): 206-14, Jun 2011.

Czupryna Julie, Tsourkas Andrew: Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. PloS one 6(5): e20073, 2011.

Elias Drew R, Cheng Zhiliang, Tsourkas Andrew: An intein-mediated site-specific click conjugation strategy for improved tumor targeting of nanoparticle systems. Small (Weinheim an der Bergstrasse, Germany) 6(21): 2460-8, Nov 2010.

Chen Antony K, Davydenko Olga, Behlke Mark A, Tsourkas Andrew: Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells. Nucleic acids research 38(14): e148, Aug 2010.

Thorek Daniel L J, Tsao Patricia Y, Arora Vaishali, Zhou Lanlan, Eisenberg Robert A, Tsourkas Andrew: In vivo, multimodal imaging of B cell distribution and response to antibody immunotherapy in mice. PloS one 5(5): e10655, 2010.

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Last updated: 05/26/2015
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