Michele Puszkarczuk Lambert

faculty photo
Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia
Attending Physician, The Children's Hospital of Philadelphia
Attending Physician, Hospital of the University of Pennsylvania
Attending Physician, Pennsylvania Hospital
Assistant Director-Clinical Coagulation Laboratory, Departments of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
Division of Hematology
3615 Civic Center Blvd
ARC 316G
Philadelphia, PA 19083
Office: 215-590-4667
Fax: 267-426-5476
Lab: 215-590-1971
Education:
BS (Biology)
Rensselaer Polytechnic Institute, 1995.
MD (Medicine)
UMDNJ - New Jersey Medical School, 1999.
MTR
University of Pennsylvania, 2010.
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Description of Itmat Expertise

Platelet disorders in pediatric patients
Thrombocytopenia
ITP

Selected Publications

Westbury Sarah K, Turro Ernest, Greene Daniel, Lentaigne Claire, Kelly Anne M, Bariana Tadbir K, Simeoni Ilenia, Pillois Xavier, Attwood Antony, Austin Steve, Jansen Sjoert Bg, Bakchoul Tamam, Crisp-Hihn Abi, Erber Wendy N, Favier Rémi, Foad Nicola, Gattens Michael, Jolley Jennifer D, Liesner Ri, Meacham Stuart, Millar Carolyn M, Nurden Alan T, Peerlinck Kathelijne, Perry David J, Poudel Pawan, Schulman Sol, Schulze Harald, Stephens Jonathan C, Furie Bruce, Robinson Peter N, van Geet Chris, Rendon Augusto, Gomez Keith, Laffan Michael A, Lambert Michele P, Nurden Paquita, Ouwehand Willem H, Richardson Sylvia, Mumford Andrew D, Freson Kathleen: Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders. Genome medicine 7(1): 36, April 2015.

Spinler Kyle R, Shin Jae-Won, Lambert Michele P, Discher Dennis E: Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood 125(3): 525-33, Jan 2015.

Bruns Ingmar, Lucas Daniel, Pinho Sandra, Ahmed Jalal, Lambert Michele P, Kunisaki Yuya, Scheiermann Christoph, Schiff Lauren, Poncz Mortimer, Bergman Aviv, Frenette Paul S: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature medicine 20(11): 1315-20, Oct 2014.

Greene Teshell K, Lyde Randolph B, Bailey Shahara C, Lambert Michele P, Zhai Li, Sabatino Denise E, Camire Rodney M, Arruda Valder R, Poncz Mortimer: Apoptotic Effects of Platelet Factor VIII on Megakaryopoiesis: Implications for a Modified Human Factor VIII for Platelet-based Gene Therapy. Journal of thrombosis and haemostasis : JTH 12(12): 2102-12, Oct 2014.

Schultz Corinna L, Mitra Nandita, Schapira Marilyn M, Lambert Michele P: Influence of the american society of hematology guidelines on the management of newly diagnosed childhood immune thrombocytopenia. JAMA pediatrics 168(10): e142214, Oct 2014.

Ben J. Samelson-Jones, Michele P. Lambert : Use of Recombinant Factor VIIa (rVIIa) in Glanzmann’s Thrombasthenia: A Systematic Review of the Literature. American Society of Pediatric Hematology/Oncology Annual Meeting, Chicago, IL April 2014.

Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123(5): 753-7, Jan 2014.

Markham S, Bevilaqua L, Zarrin H, McDonald-McGinn D, Zackai E, Lambert MP: Detecting 22q11.2 Deletion Syndrome Using Flow Cytometry. American Society for Hematology Annual Meeting, San Francisco, CA 2014.

Lambert MP, Xiao L, Poncz M: Conditional Knockout of LRP1 in Murine Megakaryocytes and Its Effects on Platelet Factor 4 Biology in Megakaryocytes. American Society of Hematology Annual Meeting, San Francisco, CA 2014.

Lambert MP, Meng R, Harper D, Xiao L, Marks MS, Poncz M: Megakaryocytes Exchange Significant Levels of Their Alpha-graunlue PF4 with Their Environment. American Society of Hematology Annual Meeting, San Francisco, CA 2014.

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Last updated: 06/01/2015
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