Jose L. Pascual L.

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Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer , Department of Surgery, University of Penn Hospital
Attending Intensivist, Philadelphia Veteran’s Affairs Medical Center, Phila. PA, University of Pennsylvania
Co-medical Director , Surgical ICU, Hospital of the University of Pennsylvania
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Perelman School of Medicine at the University of Pennsylvania
51 North 39th St,MOB 1st floor, Suite 120, Room 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
University of Ottawa, Ottawa, Ontario, 1996.
McGill University, Montreal, Quebac, 2005.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Itmat Expertise

Traumatic brain injury
Osmotherapy for intracranial hypertension.
Hemorhhagic shock resuscitation
Immunemodulation in resuscitation
Hypertonic resuscitation
Neutropil endothelial interactions
Simulation in pedagogical methods for mediacal/surgical education

Selected Publications

Kuo LE, Kaufman E, Hoffman RL, Pascual JL, Martin ND, Kelz RR, Holena DN.: Failure-to-rescue after injury is associated with preventability: The results of mortality panel review of failure-to-rescue cases in trauma. PMID: 27788924 Surgery. 2017 Mar;161(3):782-790. doi: 10.1016/j.surg.2016.08.017. Epub 2016 Oct 25. Mar 2017.

Chung JJ, Earl-Royal EC, Delgado MK, Pascual JL, Reilly PM, Wiebe DJ, Holena DN.: Where We Fail: Location and Timing of Failure to Rescue in Trauma. Am Surg. 2017 Mar 1;83(3):250-256. Mar 2017.

Nadolski G, Jacovides CL, Pascual JL.: Arteriography for Lower Gastrointestinal Hemorrhage-Reply. JAMA Surg. 2017 Feb 1;152(2):210-211. doi: 10.1001/jamasurg.2016.4262. No abstract available. Feb 2017.

Barry ME, Hochman BR, Lane-Fall MB, Zappile D, Holena DN, Smith BP, Kaplan LJ, Huffenberger A, Reilly PM, Pascual JL.: Leveraging Telemedicine Infrastructure to Monitor Quality of Operating Room to Intensive Care Unit Handoffs. Acad Med. 2017 Feb 14. Feb 2017.

Pascual JL, Cannon J. : Hemorrhagic Shock: Recognition, Pathophysiology and Management. Nova Science Publishers, Inc., New York, NY. Jan 2017.

Li S, Eisenstadt R, Kumasaka K, Johnson VE, Marks J, Nagata K, Browne KD, Smith DH, Pascual JL. : Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and hastened neurological recovery. J Trauma Acute Care Surg Mar 2016 (accepted for publication)

Nagata K, Kumasaka K, Browne KD, Li S, St-Pierre J, Cognetti J, Marks J, Johnson VE, Smith DH, Pascual JL.: Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery. J Trauma Acute Care Surg. 2016 Dec Dec 2016.

Chung JC, Earl-Royal E, Delgado MK, Pascual JL, Reilly PM, Wiebe DJ, Holena DN.: Where We Fail: Location and Timing of Failure to Rescue in Trauma. Am Surgeon, April 2016.

Hersperger S, Becker A, Heiderich G, Smith B, Holena D, Schutz A, Mancini DJ, Kumar HRN, Mook M, Holland S, Motuk S, Martin N, Reilly PM, Kim P, Pascual JL.: BECOMING A TRAUMA CENTER OVERNIGHT: Using Simulation to Train Seasoned Yet Trauma-Naïve Providers Prior to Becoming Trauma Providers. Quick Shot, 68th Annual Meeting of The Southwestern Surgical Congress, Coronado, CA April 2016.

Hatchimonji JS, Nunn AM, Holena DN, Smith BP, Martin ND, Reilly PM, Schwab CW, Pascual JL.: BOARDING ICU PATIENTS: ARE OUR ROUNDING PRACTICES SUBPAR? Quick Shot, 68th Annual Meeting of The Southwestern Surgical Congress, Coronado, CA April 2016.

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Last updated: 05/17/2017
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