Richard Aplenc

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Associate Physician, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
CTRB Room 4018
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 2674267252
Education:
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
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Description of Itmat Expertise

Dr. Aplenc's research involves molecular epidemiology, pediatric cancer Phase I clinical trials, treatment of pediatric AML, and the use of genetic polymorphism data to predict treatment response to therapeutic interventions, particularly in pediatric cancer therapy.

Selected Publications

Seif A. E., Fisher B. T., Li Y., Torp K., Rheam D. P., Huang Y. S., Harris T., Shah A., Hall M., Fieldston E. S., Kavcic M., Vujkovic M., Bailey L. C., Kersun L. S., Reilly A. F., Rheingold S. R., Walker D. M., Aplenc R.: Patient and hospital factors associated with induction mortality in acute lymphoblastic leukemia. Pediatr Blood Cancer 61(5): 846-52, May 2014.

Hagleitner M. M., Coenen M. J., Aplenc R., PatiƱo-Garcia A., Chiusolo P., Gemmati D., De Mattei M., Ongaro A., Krajinovic M., Hoogerbrugge P. M., Vermeulen S. H., Te Loo D. M.: The role of the MTHFR 677C>T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer. Pharmacogenomics J 14(2): 115-9, Apr 2014.

Aplenc R., Zhang M. J., Sung L., Zhu X., Ho V., Cooke K., Dvorak C., Hale G., Isola L., Lazarus H., McCarthy P., Olsson R., Pulsipher M., Pasquini M., Bunin N.: Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation. Blood Page: [Epub ahead of print] Apr 2014.

Diamond J. M., Akimova T., Kazi A., Shah R. J., Cantu E., Feng R., Levine M. H., Kawut S. M., Meyer N. J., Lee J. C., Hancock W. W., Aplenc R., Ware L. B., Palmer S. M., Bhorade S., Lama V. N., Weinacker A., Orens J., Wille K., Crespo M., Lederer D. J., Arcasoy S., Demissie E., Christie J. D.; Lung Transplant Outcomes Group.: Genetic variation in the prostaglandin e2 pathway is associated with primary graft dysfunction. Am J Respir Crit Care Med 89(5): 567-75, Mar 2014.

Seif A. E., Walker D. M., Li Y., Huang Y. S., Kavcic M., Torp K., Bagatell R., Fisher B. T., Aplenc R.: Dexrazoxane exposure and risk of secondary acute myeloid leukemia in pediatric oncology patients. Pediatr Blood Cancer Page: [Epub ahead of print] Mar 2014.

Fisher B. T., Kavcic M., Li Y., Seif A. E., Bagatell R., Huang Y. S., Zaoutis T., Torp K., Leckerman K. H., Aplenc R.: Antifungal prophylaxis associated with decreased induction mortality rates and resources utilized in children with new-onset acute myeloid leukemia. Clin Infect Dis 58(4): 502-8, Feb 2014.

Maude S. L., Fitzgerald J. C., Fisher B. T., Li Y., Huang Y. S., Torp K., Seif A. E., Kavcic M., Walker D. M., Leckerman K. H., Kilbaugh T. J., Rheingold S. R., Sung L., Zaoutis T. E., Berg R. A., Nadkarni V. M., Thomas N. J., Aplenc R.: Outcome of pediatric acute myeloid leukemia patients receiving intensive care in the United States. Pediatr Crit Care Med 15(2): 112-20, Feb 2014.

Fisher B. T., Harris T., Torp K., Seif A. E., Shah A., Huang Y. S., Bailey L. C., Kersun L. S., Reilly A. F., Rheingold S. R., Walker D., Li Y., Aplenc R.: Establishment of an 11-Year Cohort of 8733 Pediatric Patients Hospitalized at United States Free-standing Children's Hospitals With De Novo Acute Lymphoblastic Leukemia From Health Care Administrative Data. Medical care 52(1): e1-6, Jan 2014.

Desai A. V., Kavcic M., Huang Y. S., Herbst N., Fisher B. T., Seif A. E., Li Y., Hennessy S., Aplenc R., Bagatell R.: Establishing a high-risk neuroblastoma cohort using the pediatric health information system database. Pediatr Blood Cancer Page: [Epub ahead of print] Jan 2014.

Fisher B.T., Singh S., Huang Y.S., Li Y., Gregory J., Walker D., Seif A.E., Kavcic M., Aplenc R..: Induction mortality, ATRA administration, and resource utilization in a nationally representative cohort of children with acute promyelocytic leukemia in the United States from 1999 to 2009 Pediatr Blood Cancer 61(1): 68-73, Jan 2014.

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Last updated: 04/10/2014
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