Richard Aplenc

faculty photo
Professor of Pediatrics at the Children's Hospital of Philadelphia
Section Chief, Hematologic Malignancies, The Children's Hospital of Philadelphia
Associate Physician, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
CTRB Room 4018
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 2674267252
Education:
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.
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Description of Itmat Expertise

Dr. Aplenc's research involves molecular epidemiology, pediatric cancer Phase I clinical trials, treatment of pediatric AML, and the use of genetic polymorphism data to predict treatment response to therapeutic interventions, particularly in pediatric cancer therapy.

Selected Publications

Winestone, L. E., Getz, K. D., Miller, T. P., Wilkes, J. J., Sack, L., Li, Y., Huang, Y. S., Seif, A. E., Bagatell, R., Fisher, B. T., Epstein, A. J., Aplenc, R.: The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia. Am J Hematol 92(2): 141-148, 2017.

Jim, H. S., McLeod, H. L.: American Society of Clinical Oncology Value Framework: Importance of Accurate Toxicity Data. J Clin Oncol Page: JCO2016692079, 2017.

Johnston, D. L., Alonzo, T. A., Gerbing, R. B., Aplenc, R., Woods, W. G., Meshinchi, S., Gamis, A. S.: Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children''s Oncology Group. Pediatr Blood Cancer 64(12), 2017.

Knight, K. R., Chen, L., Freyer, D., Aplenc, R., Bancroft, M., Bliss, B., Dang, H., Gillmeister, B., Hendershot, E., Kraemer, D. F., Lindenfeld, L., Meza, J., Neuwelt, E. A., Pollock, B. H., Sung, L.: Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children''s Oncology Group. J Clin Oncol 35(4): 440-445, 2017.

Lamba, J. K., Chauhan, L., Shin, M., Loken, M. R., Pollard, J. A., Wang, Y. C., Ries, R. E., Aplenc, R., Hirsch, B. A., Raimondi, S. C., Walter, R. B., Bernstein, I. D., Gamis, A. S., Alonzo, T. A., Meshinchi, S.: CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children''s Oncology Group Trial AAML0531. J Clin Oncol 35(23): 2674-2682, 2017.

Miller, T. P., Li, Y., Getz, K. D., Dudley, J., Burrows, E., Pennington, J., Ibrahimova, A., Fisher, B. T., Bagatell, R., Seif, A. E., Grundmeier, R., Aplenc, R.: Using electronic medical record data to report laboratory adverse events. Br J Haematol 177(2): 283-286, 2017.

Miller, T. P., Li, Y., Kavcic, M., Getz, K. D., Huang, Y. V., Sung, L., Alonzo, T. A., Gerbing, R., Daves, M. H., Horton, T. M., Pulsipher, M. A., Pollard, J., Bagatell, R., Seif, A. E., Fisher, B. T., Luger, S., Gamis, A. S., Adamson, P. C., Aplenc, R.: Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children''s Oncology Group. Haematologica 102(9): e340-e343, 2017.

Tarlock, K., Alonzo, T. A., Loken, M. R., Gerbing, R. B., Ries, R. E., Aplenc, R., Sung, L., Raimondi, S. C., Hirsch, B. A., Kahwash, S. B., McKenney, A., Kolb, E. A., Gamis, A. S., Meshinchi, S.: Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children''s Oncology Group. Clin Cancer Res 23(14): 3649-3656, 2017.

Vujkovic, M., Attiyeh, E. F., Ries, R. E., Goodman, E. K., Ding, Y., Kavcic, M., Alonzo, T. A., Wang, Y. C., Gerbing, R. B., Sung, L., Hirsch, B., Raimondi, S., Gamis, A. S., Meshinchi, S., Aplenc, R.: Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children''s Oncology Group report. Blood 129(23): 3051-3058, 2017.

Vujkovic, M., Bellamy, S. L., Zuppa, A. F., Gastonguay, M., Moorthy, G. S., Ratshaa, B. R., Han, X., Steenhoff, A. P., Mosepele, M., Strom, B. L., Aplenc, R., Bisson, G. P., Gross, R.: Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana. J Acquir Immune Defic Syndr 75(4): 488-491, 2017.

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Last updated: 10/24/2017
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